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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/11/25 14:32:07」(JST)
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Phosphorolysis is the cleavage of a compound in which inorganic phosphate is the attacking group. It is analogous to hydrolysis.[1]
An example of this is glycogen breakdown by glycogen phosphorylase, which catalyzes attack by inorganic phosphate on the terminal glycosyl residue at the nonreducing end of a glycogen molecule. If the glycogen chain has n glucose units, the products of a single phosphorolytic event are one molecule of glucose 1-phosphate and a glycogen chain of n-1 remaining glucose units.
In addition, sometimes phosphorolysis is preferable to hydrolysis (like in the breakdown of glycogen or starch, as in the example above) because glucose 1-phosphate yields more ATP than does free glucose when subsequently catabolized to pyruvate.
Another example of phosphorolysis is seen in the conversion of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate in glycolysis. The mechanism involves phosphorolysis.
See also
References
- ^ Stryer, L. (1988) Biochemistry, 3rd ed., Freeman (p. 451)
UpToDate Contents
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English Journal
- Computer Simulations Reveal Substrate Specificity of Glycosidic Bond Cleavage in Native and Mutant Human Purine Nucleoside Phosphorylase.
- Isaksen GV1, Hopmann KH1, Åqvist J2, Brandsdal BO1.
- Biochemistry.Biochemistry.2016 Apr 12;55(14):2153-62. doi: 10.1021/acs.biochem.5b01347. Epub 2016 Mar 29.
- Purine nucleoside phosphorylase (PNP) catalyzes the reversible phosphorolysis of purine ribonucleosides and 2'-deoxyribonucleosides, yielding the purine base and (2'-deoxy)ribose 1-phosphate as products. While this enzyme has been extensively studied, several questions with respect to the catalytic
- PMID 26985580
- Functions, structures, and applications of cellobiose 2-epimerase and glycoside hydrolase family 130 mannoside phosphorylases.
- Saburi W1.
- Bioscience, biotechnology, and biochemistry.Biosci Biotechnol Biochem.2016 Mar 31:1-12. [Epub ahead of print]
- Carbohydrate isomerases/epimerases are essential in carbohydrate metabolism, and have great potential in industrial carbohydrate conversion. Cellobiose 2-epimerase (CE) reversibly epimerizes the reducing end d-glucose residue of β-(1→4)-linked disaccharides to d-mannose residue. CE shares catalyt
- PMID 27031293
- Structural investigation of the thymidine phosphorylase from Salmonella typhimurium in the unliganded state and its complexes with thymidine and uridine.
- Balaev VV1, Lashkov AA1, Gabdulkhakov AG1, Dontsova MV1, Seregina TA2, Mironov AS2, Betzel C3, Mikhailov AM1.
- Acta crystallographica. Section F, Structural biology communications.Acta Crystallogr F Struct Biol Commun.2016 Mar 1;72(Pt 3):224-33. doi: 10.1107/S2053230X1600162X. Epub 2016 Feb 19.
- Highly specific thymidine phosphorylases catalyze the phosphorolytic cleavage of thymidine, with the help of a phosphate ion, resulting in thymine and 2-deoxy-α-D-ribose 1-phosphate. Thymidine phosphorylases do not catalyze the phosphorolysis of uridine, in contrast to nonspecific pyrimidine nucleo
- PMID 26919527
Japanese Journal
- 乳酸菌由来マルトースホスホリラーゼを用いたα-(1→4)-グルコ二糖の高収率生産
- 中井 博之,仁平 高則,SVENSSON Birte [他]
- 新潟大学農学部研究報告 64(1), 71-79, 2011-09
- NAID 40019056812
- 2Dp02 Clostridium thermocellum由来セロデキストリンホスホリラーゼを用いた新規オリゴ糖の合成(酵素学・酵素工学,一般講演)
Related Links
- phosphorolysis [fos″fo-rol´ĭ-sis] cleavage of a chemical bond with simultaneous addition of the elements of phosphoric acid to the residues. phos·pho·rol·y·sis (fos'fŏ-rol'i-sis), A reaction analogous to hydrolysis except that the elements ...
- Origin and Etymology of phosphorolysis New Latin First Known Use: 1937 Medical Dictionary phosphorolysis play noun phos·pho·rol·y·sis \ˌfäs-fə-ˈräl-ə-səs\ Medical Definition of phosphorolysis plural phosphorolyses play : ...
★リンクテーブル★
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- phosphoryl
- 英
- glycogen phosphorylase
- 関
- グリコーゲン
- first aid step1 2006 p.98
調節
- インスリン → ↓cAMP → ↓glycogen phosphorylase
- グルカゴン、エピネフリン → ↑cAMP → ↑glycogen phosphorylase
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- Ca2+やphosphatidylinositol bisphosphate pathway
臨床関連
USMLE
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- phosphorolysis
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- 英
- phosphorolysis
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