- 関
- PBMC
WordNet
- small room in which a monk or nun lives (同)cubicle
- a device that delivers an electric current as the result of a chemical reaction (同)electric cell
- a room where a prisoner is kept (同)jail cell, prison cell
- (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
- any small compartment; "the cells of a honeycomb"
- a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
- smear with blood, as in a hunting initiation rite, where the face of a person is smeared with the blood of the kill
- temperament or disposition; "a person of hot blood"
- people viewed as members of a group; "we need more young blood in this organization"
- the fluid (red in vertebrates) that is pumped through the body by the heart and contains plasma, blood cells, and platelets; "blood carries oxygen and nutrients to the tissues and carries away waste products"; "the ancients believed that blood was the sea
- related to the key issue but not of central importance; "a peripheral interest"; "energy is far from a peripheral issue in the economy"; "peripheral issues"
- (computer science) electronic equipment connected by cable to the CPU of a computer; "disk drives and printers are important peripherals" (同)computer peripheral, peripheral device
- on or near an edge or constituting an outer boundary; the outer area; "Russias peripheral provinces"; "peripheral suburbs"
- having only one nucleus (同)mononucleate
PrepTutorEJDIC
- (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
- 『血』,『血』液 / 流血(bloodshed);殺人 / 気質,気性,血気,血潮 / 『血統』,血縁(kinship);生まれ,家柄;《the~》王家の血統 / (人種・出身国の)系 / 〈人〉‘に'初めての経験をさせる / 〈猟犬〉‘に'初めて獲物を血を味わわせる
- 周囲の; 周辺(装置)の・末梢的な・重要でない; (...に比べて)瑣末な (to); 【医】末端部の; コンピュータの周辺装置
- 純血の,純種の / 《複合語を作って》「…の血(性質)を持った」の意を表す
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/01 17:26:09」(JST)
[Wiki en表示]
"PBMC" redirects here. For the internet slang that expands to "problem's between monitor and chair", see User error.
A peripheral blood mononuclear cell (PBMC) is any blood cell having a round nucleus (as opposed to a lobed nucleus).[1] For example: a lymphocyte, a monocyte or a macrophage. These blood cells are a critical component in the immune system to fight infection and adapt to intruders. The lymphocyte population consists of T cells (CD4 and CD8 positive ~75%), B cells and NK cells (~25% combined).
These cells can be extracted from whole blood using ficoll, a hydrophilic polysaccharide that separates layers of blood, and gradient centrifugation,[2] which will separate the blood into a top layer of plasma, followed by a layer of PBMCs and a bottom fraction of polymorphonuclear cells (such as neutrophils and eosinophils) and erythrocytes. The polymorphonuclear cells can be further isolated by lysing the red blood cells. Basophils are sometimes found in both the denser and the PBMC fractions.[2]
PBMCs are widely used in research and clinical applications.
Research uses
Many scientists conducting research in the fields of immunology (including auto-immune disorders), infectious disease, hematological malignancies, vaccine development, Transplant Immunology, and high-throughput screening are frequent users of PBMCs. In many cases, PBMCs are derived from blood banks.
PBMCs have been thought to be an important route of vaccination. PBMCs from cancer patients can be extracted and cultured in vitro. Subsequently, PBMCs are challenged with specific tumor antigens such as tumor stem cell antigen. Inflammatory cytokines are usually added to aid in antigen uptake and recognition by PBMCs.
See also
References
- ^ Delves, Peter, et al. Roitt's Essential Immunology, 11th Ed. ISBN 978-1-4051-3603-7
- ^ a b Miyahira, Andrea (22 Nov 2012). "Types of immune cells present in human PBMC". sanguinebio.com. Retrieved 23 Sep 2014.
UpToDate Contents
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English Journal
- Olive oil phenolic compounds decrease the postprandial inflammatory response by reducing postprandial plasma lipopolysaccharide levels.
- Camargo A1, Rangel-Zuñiga OA2, Haro C2, Meza-Miranda ER2, Peña-Orihuela P2, Meneses ME2, Marin C2, Yubero-Serrano EM2, Perez-Martinez P2, Delgado-Lista J2, Fernandez-Real JM3, Luque de Castro MD4, Tinahones FJ5, Lopez-Miranda J2, Perez-Jimenez F2.
- Food chemistry.Food Chem.2014 Nov 1;162:161-71. doi: 10.1016/j.foodchem.2014.04.047. Epub 2014 Apr 24.
- We investigated the molecular mechanisms by which phenolic compounds (phenols) in virgin olive oil reduce the postprandial inflammatory response with the aim of identifying the transcription factor involved and the downstream effects. Olive oil-based breakfasts prepared with virgin olive oil (VOO) w
- PMID 24874372
- Sirtuin 1 stabilization by HuR represses TNF-α- and glucose-induced E-selectin release and endothelial cell adhesiveness in vitro: relevance to human metabolic syndrome.
- Ceolotto G1, De Kreutzenberg SV1, Cattelan A1, Fabricio AS2, Squarcina E2, Gion M2, Semplicini A1, Fadini GP1, Avogaro A1.
- Clinical science (London, England : 1979).Clin Sci (Lond).2014 Oct 1;127(7):449-61. doi: 10.1042/CS20130439.
- Chronic inflammation and hyperglycaemia, typical features of metabolic diseases, trigger endothelial damage and release of E-selectin, a marker of endothelial activation. In the present study, we investigated molecular pathways involved in the regulation of endothelial cell activation induced by tum
- PMID 24702436
- Interleukin 17A is an immune marker for chlamydial disease severity and pathogenesis in the koala (Phascolarctos cinereus).
- Mathew M1, Waugh C2, Beagley KW1, Timms P2, Polkinghorne A3.
- Developmental and comparative immunology.Dev Comp Immunol.2014 Oct;46(2):423-9. doi: 10.1016/j.dci.2014.05.015. Epub 2014 Jun 8.
- The koala (Phascolarctos cinereus) is an iconic Australian marsupial species that is facing many threats to its survival. Chlamydia pecorum infections are a significant contributor to this ongoing decline. A major limiting factor in our ability to manage and control chlamydial disease in koalas is a
- PMID 24915607
Japanese Journal
- Amoebal Endosymbiont Protochlamydia Induces Apoptosis to Human Immortal HEp-2 Cells
- Ito Atsushi,Matsuo Junji,Nakamura Shinji,Yoshida Asahi,Okude Miho,Hayashi Yasuhiro,Sakai Haruna,Yoshida Mitsutaka,Takahashi Kaori,Yamaguchi Hiroyuki
- PLoS ONE 7(1), e30270, 2012-01
- … Therefore, we studied the effect of Protochlamydia on the survival of human immortal cell line, HEp-2 cells and primary peripheral blood mononuclear cells (PBMC). …
- NAID 120003783337
- 2)流産における免疫学的機序の解明 : 免疫グロブリン治療は流産抑止に有効か(シンポジウム1「流産の原因と対策」,第63回日本産科婦人科学会・学術講演会)
- 島田 茂樹
- 日本産科婦人科學會雜誌 63(12), 2153-2166, 2011-12-01
- … Results: A: In the peripheral blood at the midluteal phases, no significant differences in the NKT cell percentages were found between RSA and control women. … However, in RSA women, the CD4+IL-4+cell and CD8+IL-4+cell percentages were significantly higher, and the Th1/Th2 and Tc1/Tc2 cell ratios were significantly lower, than those in the control. …
- NAID 110008799035
Related Links
- A peripheral blood mononuclear cell (PBMC) is any blood cell having a round nucleus. For example: a lymphocyte, a monocyte or a macrophage. These blood cells are a critical component in the immune system to fight infection and adapt to ...
Related Pictures
![hqdefault.jpg](https://1mg.info/0/b/b/1242.jpg)
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![Peripheral blood mononuclear cell](https://1mg.info/0/a/8/0286.jpg)
![Peripheral blood mononuclear cell](https://1mg.info/0/b/b/1244.jpg)
![Peripheral Blood Mononuclear Cell](https://1mg.info/0/b/b/1246.jpg)
★リンクテーブル★
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- 関
- peripheral blood mononuclear cell
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- 英
- peripheral blood mononuclear cell、PBMC
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- 末梢性の、末梢の、末梢神経性の、末梢神経の、周辺性の
- 関
- peripheral nerve、peripherally、peripheric、periphery
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細胞
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血液