WordNet

the 9th letter of the Roman alphabet (同)i
precursor of pepsin; stored in the stomach walls and converted to pepsin by hydrochloric acid in the stomach

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1. 胃癌スクリーニング gastric cancer screening
2. 胃炎および胃障害の分類と診断 classification and diagnosis of gastritis and gastropathy
3. 胃酸分泌の生理学 physiology of gastric acid secretion
4. 化生（慢性）萎縮性胃炎 metaplastic chronic atrophic gastritis
5. ビタミンB12および葉酸欠乏症の診断および治療 diagnosis and treatment of vitamin b12 and folate deficiency

Kitamura Y1, Yoshihara M2, Ito M1, Boda T1, Matsuo T3, Kotachi T1, Tanaka S3, Chayama K1.
Journal of gastroenterology and hepatology.J Gastroenterol Hepatol.2015 May 14. doi: 10.1111/jgh.12987. [Epub ahead of print]
OBJECTIVE: Gastric cancer develops due to atrophic gastritis induced by Helicobacter pylori (H. pylori) infection. Serum levels of pepsinogen (PG) are known to be excellent markers for evaluating the degree of atrophic gastritis. We investigated whether chronic gastritis could be diagnosed by evalua
PMID 25974661

Long-term dynamics of gastric biomarkers after eradication of Helicobacter pylori infection.

Daugule I1, Ruskule A, Moisejevs G, Rudzite D, Jonaitis L, Janciauskas D, Kiudelis G, Kupcinskas L, Leja M.
European journal of gastroenterology & hepatology.Eur J Gastroenterol Hepatol.2015 May;27(5):501-5. doi: 10.1097/MEG.0000000000000308.
BACKGROUND: Secretion of pepsinogen I (PgI), pepsinogen II (PgII), fasting gastrin-17 (fG-17) and stimulated gastrin-17 (sG-17) changes after Helicobacter pylori eradication. Few data are available on the long-term dynamics of gastric biomarkers after H. pylori eradication.The aim of this study was
PMID 25822857

Polymorphic rs9471643 and rs6458238 upregulate PGC transcription and protein expression in overdominant or dominant models.

He C1, Xu Q, Tu H, Sun L, Gong Y, Liu J, Yuan Y.
Molecular carcinogenesis.Mol Carcinog.2015 Apr 7. doi: 10.1002/mc.22305. [Epub ahead of print]
The pepsinogen C (PGC) gene encodes a major differentiation biomarker for gastric mucosa and has two single nucleotide polymorphisms, rs9471643 G>C and rs6458238 G>A, within its 5' upstream region that are involved in gastric carcinogenesis. However, in what genetic models the two polymorphism
PMID 25857852

倉内静香,高橋一平,松坂方士 [他]
弘前医学 63(2-4), 105-115, 2012
… pylori antigen in stools, serum pepsinogen I, serum pepsinogen II and serum Se concentration were measured. … pylori infection and AG, and it negatively correlated with serum pepsinogen I level. … Thus, this study suggests that AG with gastric cancer decreases serum pepsinogen I secretion, and leads to decreased absorption of Se. …
NAID 40019512730

Gastric cancer screening by combined assay for serum anti-Helicobacter pylori IgG antibody and serum pepsinogen levels - "ABC method"

MIKI Kazumasa
Proceedings of the Japan Academy, Series B 87(7), 405-414, 2011
… The current status of screening for gastric cancer-risk (gastritis A, B, C, D) method using combined assay for serum anti-Helicobacter pylori (Hp) IgG antibody and serum pepsinogen (PG) levels, “ABC method”, was reviewed and the latest results of our ongoing trial are reported. …
NAID 130001066427