関: hypothalamus、lamina terminalis、OVLT

WordNet

a basal part of the diencephalon governing autonomic nervous system
relating to or occurring in a term or fixed period of time; "terminal examinations"; "terminal payments"
a contact on an electrical device (such as a battery) at which electric current enters or leaves (同)pole
station where transport vehicles load or unload passengers or goods (同)terminus, depot
electronic equipment consisting of a device providing access to a computer; has a keyboard and display
being or situated at an end; "the endmost pillar"; "terminal buds on a branch"; "a terminal station"; "the terminal syllable"
causing or ending in or approaching death; "a terminal patient"; "terminal cancer"
of or relating to or situated at the ends of a delivery route; "freight pickup is a terminal service"; "terminal charges"
wind instrument whose sound is produced by means of pipes arranged in sets supplied with air from a bellows and controlled from a large complex musical keyboard (同)pipe_organ
a fully differentiated structural and functional unit in an animal that is specialized for some particular function
a government agency or instrument devoted to the performance of some specific function; "The Census Bureau is an organ of the Commerce Department"
a periodical that is published by a special interest group; "the organ of the communist party"
a thin plate or layer (especially of bone or mineral)

PrepTutorEJDIC

『終りの』,末端の / 毎期の,定期の;学期末の / 『死に至る』, / 末端 / (電池の)端子 / (町の中心に近い)空港バス発着場;(一般に,鉄道・バスの)終点,終着駅
『オルガン』,パイプオルガン(pipe organ),リードオルガン(reed organ),電子オルガン(electronic organ),手回しオルガン(barrel organ) / (動植物の)『器官』 / (政党・会社などの)機関誌,機関紙 / 《しばしば複数形で》(行動・実施などの)組織,機関
薄層,薄片,薄板

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/21 23:40:04」(JST)

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The organum vasculosum of the lamina terminalis (OVLT or supraoptic crest) is one of the circumventricular organs of the brain. Other circumventricular organs are the subfornical organ (SFO) and the area postrema in the brainstem.

AV3V region

The OVLT and the SFO are both strongly interconnected with the median preoptic nucleus of the hypothalamus (the nucleus medianus), and together these three structures comprise the "anterioventral third ventricle (AV3V) region" -- the region anterior and ventral to the third ventricle. The AV3V region is very important in the regulation of fluid and electrolyte balance by controlling thirst, sodium excretion, blood volume regulation, and vasopressin secretion.

Function

The OVLT lacks a blood brain barrier, and so neurons in this region can respond to osmotic pressure factors that are present in the systemic circulation.^[1]

Some neurons in the OVLT are osmoreceptors, being sensitive to the osmotic pressure of the blood. These neurons project to the supraoptic nucleus and paraventricular nucleus to regulate the activity of vasopressin-secreting neurons. In a situation of lowered blood volume, secretion of renin by the kidneys results in the production of angiotensin II, which stimulates the OVLT and SFO to complete a positive feedback loop.^[2] These neurons also project to the nucleus medianus (also called the medial preoptic nucleus) which is involved in controlling thirst.

References

^ Koeppen, Bruce M. (2010). Berne & Levy Physiology 6th Edition Updated Edition. pp. 228–229. ISBN 978-0-323-07362-2.
^ FITZGERALD, M J Turlough (2012). Clinical Neuroanatomy and Neuroscience. Philadelphia: Saunders Elsevier. p. 281. ISBN 978-0-7020-3738-2.

External links

http://www.sci.uidaho.edu/med532/lamina.htm

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English Journal

Effects of Peritoneal Sepsis on Rat Central Osmoregulatory Neurons Mediating Thirst and Vasopressin Release.

Stare J1, Siami S2, Trudel E3, Prager-Khoutorsky M3, Sharshar T4, Bourque CW5.
The Journal of neuroscience : the official journal of the Society for Neuroscience.J Neurosci.2015 Sep 2;35(35):12188-97. doi: 10.1523/JNEUROSCI.5420-13.2015.
Sepsis is a life-threatening condition caused by the systemic inflammatory response to a bacterial infection. Although much is known about the cellular and molecular changes that characterize the peripheral inflammatory response to sepsis, almost nothing is known of the neuronal changes that cause a
PMID 26338329

Effects of Prolactin and Lactation on A15 Dopamine Neurones in the Rostral Preoptic Area of Female Mice.

Brown RS1, Herbison AE2, Grattan DR1.
Journal of neuroendocrinology.J Neuroendocrinol.2015 Sep;27(9):708-717. doi: 10.1111/jne.12297.
There are several distinct populations of dopamine neurones in the hypothalamus. Some of these, such as the A12 tuberoinfundibular dopamine neurones and the A14 periventricular dopamine neurones, are known to be regulated by the anterior pituitary hormone prolactin, whereas others, such as the A13 z
PMID 26132331

Anatomical organization of the rat organum vasculosum laminae terminalis.

Prager-Khoutorsky M1, Bourque CW2.
American journal of physiology. Regulatory, integrative and comparative physiology.Am J Physiol Regul Integr Comp Physiol.2015 Aug 15;309(4):R324-37. doi: 10.1152/ajpregu.00134.2015. Epub 2015 May 27.
The organum vasculosum of the laminae terminalis (OVLT) is a circumventricular organ located along the ventral part of the anterior wall of the third ventricle. Because it lacks a complete blood-brain barrier (BBB), blood-borne signals detected in the OVLT provide the brain with information from the
PMID 26017494

Japanese Journal

Cyclooxygenase Inhibitors Attenuate Augmented Glutamate Release in Organum Vasculosum Laminae Terminalis and Fever Induced by Staphylococcal Enterotoxin A

Huang Wu-Tein,Wang Jhi-Joung,Lin Mao-Tsun
Journal of pharmacological sciences 94(2), 192-196, 2004-02-01
… Both the hyperthermia and augmented glutamate release in the organum vasculosum laminae terminalis (OVLT) after an intravenous dose (30 ng/kg) of staphylococcal enterotoxin A (SEA) were significantly reduced by pretreatment with intravenous administration of cyclooxygenase inhibitors such as aspirin (1 – 10 mg/kg), sodium salicylate (1 – 10 mg/kg), or diclofenac (10 mg/kg). …
NAID 130000073872

マウス神経細胞質内に観察される核小体様封入体とその脳内分布: Holmes変法による研究

加藤好光,岸千絵子,高野洋人,山田敬喜,磯村源蔵
形態・機能 1(2), 3-11, 2003
各種哺乳動物の中枢神経系において、核小体様封入体 (封入体) の存在が電顕により報告されているが、その脳内分布の系統的研究は行われていない。ddYマウス青斑核では、パラフィン切片をHolmes変法で染色する事により光顕レベルで封入体の存在を明らかにすることが出来る。<BR>本研究では、11種の近交系マウスにおいても、ddYマウスと同様に核小体様封入体が観察されるか否かを検索し、両マウス …
NAID 130004185326

The capillary of the organum vasculosum laminae terminalis (OVLT) in rabbits is more permeable to horseradish peroxidase (HRP) than that in rats

Yamaguchi Kazuhito,Sieber Nancy C.
Journal of electron microscopy 49(6), 783-791, 2000-12-01
NAID 10013017623

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リンク元	「終末器官」「organum vasculosum of lamina terminalis」「終板器官」「OVLT」
関連記事	「terminal」「laminae」「vasculosum」「organ」「organum」