new quinolone



  1. unfamiliar; "new experiences"; "experiences new to him"; "errors of someone new to the job"
  2. having no previous example or precedent or parallel; "a time of unexampled prosperity" (同)unexampled
  3. (of crops) harvested at an early stage of development; before complete maturity; "new potatoes"; "young corn" (同)young
  4. not of long duration; having just (or relatively recently) come into being or been made or acquired or discovered; "a new law"; "new cars"; "a new comet"; "a new friend"; "a new year"; "the New World"
  5. other than the former one(s); different; "they now have a new leaders"; "my new car is four years old but has only 15,000 miles on it"; "ready to take a new direction"
  6. unaffected by use or exposure; "it looks like new"
  7. information about recent and important events; "they awaited news of the outcome" (同)intelligence, tidings, word
  8. informal information of any kind that is not previously known to someone; "it was news to me"
  9. information reported in a newspaper or news magazine; "the news of my death was greatly exaggerated"
  10. in use after medieval times; "New Eqyptian was the language of the 18th to 21st dynasties"


  1. (その状態になってまだ時間がたっていなくて)『新しい』;《名詞の前にのみ用いて》新しく発見(発明)された,新しく来た / 《名詞の前にのみ用いて》目新しい,初めて聞く,なじみのない / 《補語にのみ用いて》(人が)(…に)『まだ慣れていない』,(…を)よく知らない《『to』+『名』》 / 《補語にのみ用いて》(人が)(…から)出てきたばかりの《+『from』+『名』》 / 《名詞の前にのみ用いて》まだ着た(使った)ことがない,新品の / 新たに始まる;(肉体的・精神的に)一新した / 《おもに複合語を作って》最近(recently);新たに,新しく(newly)
  2. (新しい)『報道』,記事;(一般的に)知らせ,たより) / (耳新しい)『事件』,でき事 / 《N-》(新聞名として)…新聞

UpToDate Contents

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English Journal

  • Effects of novel acylhydrazones derived from 4-quinolone on the acetylcholinesterase activity and Aβ42 peptide fibrils formation.
  • da Silva GS1, Figueiró M2, Tormena CF1, Coelho F1, Almeida WP2.
  • Journal of enzyme inhibition and medicinal chemistry.J Enzyme Inhib Med Chem.2016 Dec;31(6):1464-70. doi: 10.3109/14756366.2016.1144597. Epub 2016 Mar 1.
  • Acetylcholinesterase inhibitors and compounds that trigger Aβ amyloid oligomerization and fibrillization represent an opportunity to discover new drug candidates to treat Alzheimer's disease. In this work, we synthesized nine new acylhydrazones and a known one, both employing 3-carboethoxy-4-quinol
  • PMID 26928712
  • Role of ppGpp in Pseudomonas aeruginosa acute pulmonary infection and virulence regulation.
  • Xu X1, Yu H1, Zhang D2, Xiong J2, Qiu J2, Xin R2, He X2, Sheng H2, Cai W2, Jiang L2, Zhang K3, Hu X4.
  • Microbiological research.Microbiol Res.2016 Nov;192:84-95. doi: 10.1016/j.micres.2016.06.005. Epub 2016 Jun 15.
  • During infection, bacteria might generate adaptive responses to facilitate their survival and colonization in the host environment. The alarmone guanosine 5'-triphosphate-3'-diphosphate (ppGpp), the levels of which are regulated by the RelA and SpoT enzymes, plays a critical role in mediating bacter
  • PMID 27664726
  • Development of hemiacetal esterified levofloxacin to prevent chelation with metal-containing drugs.
  • Otori T1, Matzno S1, Kawase A1, Iwaki M1, Kimachi T2, Nishiwaki K1, Figoni WC1, Tominaga R1, Asahide M1, Nishikata M1, Ishii Y3, Matsuyama K4.
  • The Journal of pharmacy and pharmacology.J Pharm Pharmacol.2016 Oct 24. doi: 10.1111/jphp.12642. [Epub ahead of print]
  • OBJECTIVES: To avoid the chelate formation between levofloxacin (LVFX) and aluminium hydroxide in gastrointestinal tract, an ethoxycarbonyl 1-ethyl hemiacetal ester of levofloxacin (LVFX-EHE) was synthesised as a prodrug.METHODS: The effects of aluminium hydroxide on the bioavailability of LVFX foll
  • PMID 27774590

Japanese Journal

  • 生後3か月の乳児に発症したニューキノロン耐性淋菌性結膜炎の1例 (特集 第65回日本臨床眼科学会講演集(5))
  • 岡島 行伸,小早川 信一郎,柿栖 康二 [他]
  • 臨床眼科 66(7), 1003-1007, 2012-07
  • NAID 40019385731
  • 新しいキノロン耐性機序 (特集 多剤耐性菌) -- (特論)

Related Links

Rheumatic disease after use of a fluoroquinolone (norfloxacin) was first reported eleven years later. In response to a 1995 letter published in the New England Journal of Medicine, representatives of the U.S. Food and Drug Administration ...

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  • n.
number of experimentsample size
  • pの前の[n]はmと記載する。synptom→symptom



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