unexampled

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Preclinical pharmacology, ocular tolerability and ocular hypotensive efficacy of a novel non-peptide bradykinin mimetic small molecule.

Sharif NA1, Li L2, Katoli P2, Xu S2, Veltman J2, Li B2, Scott D2, Wax M2, Gallar J3, Acosta C3, Belmonte C3.
Experimental eye research.Exp Eye Res.2014 Nov;128:170-80. doi: 10.1016/j.exer.2014.10.008. Epub 2014 Oct 11.
We sought to characterize the ocular pharmacology, tolerability and intraocular pressure (IOP)-lowering efficacy of FR-190997, a non-peptidic bradykinin (BK) B2-receptor agonist. FR-190997 possessed a relatively high receptor binding affinity (Ki = 27 nM) and a high in vitro potency (EC50 = 18.3 ±
PMID 25307520

Keum H1, Kim S2.
Journal of visualized experiments : JoVE.J Vis Exp.2014 Aug 1;(90):e51974. doi: 10.3791/51974.
Transfer printing is a method to transfer solid micro/nanoscale materials (herein called 'inks') from a substrate where they are generated to a different substrate by utilizing elastomeric stamps. Transfer printing enables the integration of heterogeneous materials to fabricate unexampled structures
PMID 25146178

Shchelkunov SN1.
Advances in virology.Adv Virol.2012;2012:524743. doi: 10.1155/2012/524743. Epub 2012 Jul 30.
In the course of evolution, viruses have developed various molecular mechanisms to evade the defense reactions of the host organism. When understanding the mechanisms used by viruses to overcome manifold defense systems of the animal organism, represented by molecular factors and cells of the immune
PMID 22899927