neuronal apoptosis-inhibitory protein

神経細胞アポトーシス抑制タンパク質

関

NAIP

• 抗アポトーシス因子

WordNet

1. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
2. a substance that retards or stops an activity
3. a type of cell death in which the cell uses specialized cellular machinery to kill itself; a cell suicide mechanism that enables metazoans to control cell number and eliminate cells that threaten the animals survival (同)programmed_cell_death, caspase-mediated cell death
4. restrictive of action; "a repressive regime"; "an overly strict and inhibiting discipline" (同)repressive, repressing

PrepTutorEJDIC

1. 蛋白(たんばく)質
2. 抑制する人(物) / 化学反応抑制剤

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/22 17:07:47」(JST)

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NLR family, apoptosis inhibitory protein
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2VM5
Identifiers
Symbols	NAIP; BIRC1; NLRB1; psiNAIP
External IDs	OMIM: 600355 MGI: 1298223 HomoloGene: 113589 GeneCards: NAIP Gene
Gene Ontology Molecular function • cysteine-type endopeptidase inhibitor activity • protein binding • ATP binding • nucleoside-triphosphatase activity • metal ion binding Cellular component • cytoplasm • basolateral plasma membrane Biological process • inflammatory response • nervous system development • negative regulation of apoptotic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of neuron apoptotic process • innate immune response Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4671	17940
Ensembl	ENSG00000249437	ENSMUSG00000021640
UniProt	Q13075	Q9QWK5
RefSeq (mRNA)	NM_004536	NM_008670
RefSeq (protein)	NP_004527	NP_032696
Location (UCSC)	Chr 5: 70.26 – 70.32 Mb	Chr 13: 100.41 – 100.45 Mb
PubMed search	[1]	[2]

Baculoviral IAP repeat-containing protein 1 is a protein that in humans is encoded by the NAIP gene.

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1.

The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

References

Further reading

• van der Steege G, Draaijers TG, Grootscholten PM, et al. (1995). "A provisional transcript map of the spinal muscular atrophy (SMA) critical region.". Eur. J. Hum. Genet. 3 (2): 87–95. PMID 7552146. 
• Liston P, Roy N, Tamai K, et al. (1996). "Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.". Nature 379 (6563): 349–53. doi:10.1038/379349a0. PMID 8552191. 
• Chen Q, Baird SD, Mahadevan M, et al. (1998). "Sequence of a 131-kb region of 5q13.1 containing the spinal muscular atrophy candidate genes SMN and NAIP.". Genomics 48 (1): 121–7. doi:10.1006/geno.1997.5141. PMID 9503025. 
• Monani UR, Lorson CL, Parsons DW, et al. (1999). "A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2.". Hum. Mol. Genet. 8 (7): 1177–83. doi:10.1093/hmg/8.7.1177. PMID 10369862. 
• Yamamoto K, Sakai H, Hadano S, et al. (1999). "Identification of two distinct transcripts for the neuronal apoptosis inhibitory protein gene.". Biochem. Biophys. Res. Commun. 264 (3): 998–1006. doi:10.1006/bbrc.1999.1615. PMID 10544044. 
• Mercer EA, Korhonen L, Skoglösa Y, et al. (2000). "NAIP interacts with hippocalcin and protects neurons against calcium-induced cell death through caspase-3-dependent and -independent pathways.". EMBO J. 19 (14): 3597–607. doi:10.1093/emboj/19.14.3597. PMC 313967. PMID 10899114. 
• Sanna MG, da Silva Correia J, Ducrey O, et al. (2002). "IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition.". Mol. Cell. Biol. 22 (6): 1754–66. doi:10.1128/MCB.22.6.1754-1766.2002. PMC 135597. PMID 11865055. 
• Akutsu T, Nishio H, Sumino K, et al. (2002). "Molecular genetics of spinal muscular atrophy: contribution of the NAIP gene to clinical severity.". The Kobe journal of medical sciences 48 (1-2): 25–31. PMID 11912351. 
• Xu M, Okada T, Sakai H, et al. (2002). "Functional human NAIP promoter transcription regulatory elements for the NAIP and PsiNAIP genes.". Biochim. Biophys. Acta 1574 (1): 35–50. doi:10.1016/S0167-4781(01)00343-8. PMID 11955612. 
• Notarbartolo M, Cervello M, Dusonchet L, D'Alessandro N (2002). "NAIP-deltaEx10-11: a novel splice variant of the apoptosis inhibitor NAIP differently expressed in drug-sensitive and multidrug-resistant HL60 leukemia cells.". Leuk. Res. 26 (9): 857–62. doi:10.1016/S0145-2126(02)00016-4. PMID 12127562. 
• Lindholm D, Mercer EA, Yu LY, et al. (2002). "Neuronal apoptosis inhibitory protein: Structural requirements for hippocalcin binding and effects on survival of NGF-dependent sympathetic neurons.". Biochim. Biophys. Acta 1600 (1-2): 138–47. doi:10.1016/S1570-9639(02)00454-5. PMID 12445469. 
• Damiano JS, Oliveira V, Welsh K, Reed JC (2004). "Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses.". Biochem. J. 381 (Pt 1): 213–9. doi:10.1042/BJ20031506. PMC 1133779. PMID 15107016. 
• Davoodi J, Lin L, Kelly J, et al. (2004). "Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9.". J. Biol. Chem. 279 (39): 40622–8. doi:10.1074/jbc.M405963200. PMID 15280366. 
• Aubin D, Gagnon A, Grunder L, et al. (2004). "Adipogenic and antiapoptotic protein levels in human adipose stromal cells after weight loss.". Obes. Res. 12 (8): 1231–4. doi:10.1038/oby.2004.156. PMID 15340105. 
• Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5.". Nature 431 (7006): 268–74. doi:10.1038/nature02919. PMID 15372022. 
• Romanish MT, Lock WM, van de Lagemaat LN, et al. (2007). "Repeated recruitment of LTR retrotransposons as promoters by the anti-apoptotic locus NAIP during mammalian evolution.". PLoS Genet. 3 (1): e10. doi:10.1371/journal.pgen.0030010. PMC 1781489. PMID 17222062. 
• Maier JK, Balabanian S, Coffill CR, et al. (2007). "Distribution of neuronal apoptosis inhibitory protein in human tissues.". J. Histochem. Cytochem. 55 (9): 911–23. doi:10.1369/jhc.6A7144.2007. PMID 17510375. 

External links

• Neuronal Apoptosis-Inhibitory Protein at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. アポトーシスと自己免疫疾患 apoptosis and autoimmune disease
• 2. 筋萎縮性側索硬化症の疫学および病因 epidemiology and pathogenesis of amyotrophic lateral sclerosis
• 3. 心臓の虚血性再潅流障害 ischemic reperfusion injury of the heart
• 4. 慢性骨髄性白血病の細胞生物学および分子生物学 cellular and molecular biology of chronic myeloid leukemia
• 5. パーキンソン病の病因および発症機序 etiology and pathogenesis of parkinson disease

English Journal

• Quercetin-3-O-(2″-galloyl)-α-L-rhamnopyranoside attenuates cholesterol oxidation product-induced apoptosis by suppressing NF-κB-mediated cell death process in differentiated PC12 cells.

• Lee da H1, Nam YJ, Lee CS.
• Naunyn-Schmiedeberg's archives of pharmacology.Naunyn Schmiedebergs Arch Pharmacol.2015 Aug;388(8):869-81. doi: 10.1007/s00210-015-1120-7. Epub 2015 Apr 7.
• Cholesterol oxidation products are suggested to be involved in neuronal cell degeneration. We examined the preventive effect of quercetin-3-O-(2″-galloyl)-α-L-rhamnopyranoside (QGR), a quercetin derivative, on the cholesterol oxidation product-induced neuronal cell death using differentiated PC12
• PMID 25845326

• Raf-1 Kinase Inhibitory Protein (RKIP) Promotes Retinal Ganglion Cell Survival and Axonal Regeneration Following Optic Nerve Crush.

• Wei J1, Jiang H, Gao H, Wang G.
• Journal of molecular neuroscience : MN.J Mol Neurosci.2015 Jul 10. [Epub ahead of print]
• Raf-1 kinase inhibitory protein (RKIP), a member of the phosphatidylethanolamine-binding protein (PEBP) family, plays an important role in neuronal apoptosis and cognitive deficits associated with neurodegenerative diseases. However, the biological function of RKIP in the retina is still unclear. Th
• PMID 26160696

• P2Y6 Receptor-Mediated Microglial Phagocytosis in Radiation-Induced Brain Injury.

• Xu Y1,2, Hu W3, Liu Y4, Xu P1, Li Z1, Wu R1, Shi X1, Tang Y5,6.
• Molecular neurobiology.Mol Neurobiol.2015 Jun 23. [Epub ahead of print]
• Microglia are the resident immune cells and the professional phagocytic cells of the CNS, showing a multitude of cellular responses after activation. However, how microglial phagocytosis changes and whether it is involved in radiation-induced brain injury remain unknown. In the current study, we fou
• PMID 26099306

Japanese Journal

• Lower Incidence of Deletions in the Survival of Motor Neuron Gene and the Neuronal Apoptosis Inhibitory Protein Gene in Children with Spinal Muscular Atrophy from Serbia

• MISKOVIC Marijana,LALIC Tanja,RADIVOJEVIC Danijela,CIRKOVIC Sanja,VLAHOVIC Gordana,ZAMUROVIC Dragan,GUC-SCEKIC Marija
• Tohoku journal of experimental medicine 225(3), 153-159, 2011-11-01
• NAID 10030196004

• Combination of SMN2 copy number and NAIP deletion predicts disease severity in spinal muscular atrophy

• WATIHAYATI Mohd Shamshudin,FATEMEH Hayati,MARINI Marzuki,ATIF Amin Baig,ZAHIRUDDIN Wan Mohd,SASONGKO Teguh Haryo,TANG Thean Hock,ZABIDI-HUSSIN ZAMH,NISHIO Hisahide,ZIFALIL Bin Alwi
• Brain & development 31(1), 42-45, 2009-01-01
• NAID 10025578251

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★リンクテーブル★

リンク元	「NAIP」「神経細胞アポトーシス抑制タンパク質」
関連記事	「inhibitor」「neuronal」「inhibitory」「inhibitory protein」

「NAIP」

　　[★]

• 神経細胞アポトーシス抑制タンパク質

関

neuronal apoptosis-inhibitory protein

「神経細胞アポトーシス抑制タンパク質」

　　[★]

英

neuronal apoptosis-inhibitory protein、NAIP

「inhibitor」

　　[★]

• n.

• 阻害剤、阻害薬、抑制薬、抑制剤、(内在性物質について)インヒビター、抑制物質

関

blocker、depressant、suppressant

　 　

「neuronal」

　　[★]

• 神経細胞の、ニューロンの、神経型の

関

nerve cell、neural、neural cell、neuron、neuronal cell、neurone

「inhibitory」

　　[★]

• 抑制性の、抑制的な、阻害性の

関

inhibiting、suppressive

　

「inhibitory protein」

　　[★]

• 抑制タンパク質、抑制蛋白質

関

repressor protein