neuromuscular junction disease

• 神経筋接合部疾患

関

neuromuscular junction disorder、neuromuscular transmission disorder

WordNet

1. an impairment of health or a condition of abnormal functioning
2. the state of being joined together (同)conjunction, conjugation, colligation
3. an act of joining or adjoining things (同)adjunction
4. something that joins or connects (同)conjunction
5. the place where two or more things come together
6. caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological
7. affecting or characteristic of both neural and muscular tissue

PrepTutorEJDIC

1. (体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
2. 女性の話術芸人 =diseur
3. 〈U〉〈C〉連結すること(された状態),『結合』,連合,合体 / 〈C〉『結合点』,連結(接合,合流)点 / 〈C〉(鉄道の)『連絡駅』,接続駅
4. 病気にかかった / 病的な,不健全な(morbid)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/28 10:19:16」(JST)

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[Wiki en表示]

Neuromuscular junction disease
Classification and external resources
MeSH	D020511

Neuromuscular junction disease is a medical condition where the normal conduction through the neuromuscular junction fails to function correctly.

Autoimmune

In diseases such as myasthenia gravis, the End Plate Potential (EPP) fails to effectively activate the muscle fiber due to an autoimmune reaction against acetylcholine receptors, resulting in muscle weakness and fatigue.

Myasthenia gravis is caused most commonly by auto-antibodies against the acetylcholine receptor.

It has recently been realized that a second category of gravis is due to auto-antibodies against MuSK.

A different condition, Lambert-Eaton myasthenic syndrome, is usually associated with presynaptic antibodies to the voltage-dependent calcium channel.

It is possible for these conditions to coexist.

Toxins

Various toxins, such as botulinum toxin prevent the release of acetylcholine, resulting in muscle paralysis.

References

UpToDate Contents

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• 1. 末梢神経疾患および筋疾患の鑑別診断 differential diagnosis of peripheral nerve and muscle disease
• 2. 神経筋接合部に作用する毒素の概要 overview of neuromuscular junction toxins
• 3. Lambert-Eaton筋無力症候群の臨床的特徴および診断 clinical features and diagnosis of lambert eaton myasthenic syndrome
• 4. 新生児および幼児における神経筋接合部障害 neuromuscular junction disorders in newborns and infants
• 5. 眼瞼下垂症の概要 overview of ptosis

English Journal

• Measuring Neuromuscular Junction Functionality in the SOD1(G93A) Animal Model of Amyotrophic Lateral Sclerosis.

• Rizzuto E1, Pisu S, Musarò A, Del Prete Z.
• Annals of biomedical engineering.Ann Biomed Eng.2015 Sep;43(9):2196-206. doi: 10.1007/s10439-015-1259-x. Epub 2015 Jan 29.
• Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that leads to motor neuron degeneration, alteration in neuromuscular junctions (NMJs), muscle atrophy, and paralysis. To investigate the NMJ functionality in ALS we tested, in vitro, two innervated muscle types excised from SOD
• PMID 25631208

• Transient effects of levamisole on Brugia malayi microfilariae.

• Mostafa E1, Storey B, Farghaly AM, Afify HA, Taha AA, Wolstenholme AJ.
• Invertebrate neuroscience : IN.Invert Neurosci.2015 Sep;15(3):181. doi: 10.1007/s10158-015-0181-0. Epub 2015 Jul 18.
• Levamisole is an anthelmintic drug that acts by activating nicotinic acetylcholine receptors at the nematode neuromuscular junction and causing paralysis. We measured the in vitro effects of levamisole on the motility of Brugia malayi microfilariae; after 2 h incubation the apparent IC50 was 2.68 
• PMID 26187649

• HuR Mediates Changes in the Stability of AChR β-Subunit mRNAs after Skeletal Muscle Denervation.

• Joassard OR1, Bélanger G1, Karmouch J2, Lunde JA1, Shukla AH1, Chopard A1, Legay C2, Jasmin BJ3.
• The Journal of neuroscience : the official journal of the Society for Neuroscience.J Neurosci.2015 Aug 5;35(31):10949-62. doi: 10.1523/JNEUROSCI.1043-15.2015.
• Acetylcholine receptors (AChRs) are heteromeric membrane proteins essential for neurotransmission at the neuromuscular junction. Previous work showed that muscle denervation increases expression of AChR mRNAs due to transcriptional activation of AChR subunit genes. However, it remains possible that
• PMID 26245959

Japanese Journal

• 不動・廃用症候群

• The Japanese Journal of Rehabilitation Medicine 52(4-5), 265-271, 2015
• NAID 130005068617

• 反復神経刺激試験において長期経過観察を行った重症筋無力症の1例

• 医学検査 63(4), 407-412, 2014
• NAID 130004690640

• 教育講演１５　自己免疫性神経筋接合部疾患の病態と治療

• 臨床神経学 51(11), 872-876, 2011
• NAID 130004504895

Related Links

• Neuromuscular Junction Disease Software - Free Download ...

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• Neuromuscular junction in health and disease

reaches its target. The high concentration of AChE within the cleft terminates the action of ACh preventing it from activating the postsynaptic nicotinic acetylcholine recep-tors (nAChRs) more than once. Also contained within the cleft ...

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★リンクテーブル★

リンク元	「neuromuscular junction disorder」「neuromuscular transmission disorder」「神経筋接合部疾患」
関連記事	「disease」「junction」

「neuromuscular junction disorder」

　　[★]

神経筋接合部障害

関

neuromuscular junction disease、neuromuscular transmission disorder

「neuromuscular transmission disorder」

　　[★]

• 神経筋伝達障害

関

neuromuscular junction disease、neuromuscular junction disorder

「神経筋接合部疾患」

　　[★]

英

neuromuscular junction disease

関

神経筋接合部障害、神経筋伝達障害

「disease」

　　[★]

• n.

疾患：illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)

特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)

• something that is very wrong with people's attitudes, way of life or with society.

関

ail、ailment、disease entity、disorder、ill、illness、malady、sick、sickness

• 注意

disease ≠ illness ≠ disorder

　 　 　

「junction」

　　[★]

• n.

• 接合部、移行部、接合点、ジャンクション

関

junctional、junctional region、juncture