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English Journal
- S100A10 downregulation inhibits the phagocytosis of Cryptococcus neoformans by murine brain microvascular endothelial cells.
- Chen Y, Chen J, Wen H, Gao P, Wang J, Zheng Z, Gu J.SourceDepartment of Dermatology, Huashan Hospital, Fudan University, 12 Wulumuqizhong Road, Shanghai 200040, China.
- Microbial pathogenesis.Microb Pathog.2011 Sep;51(3):96-100. Epub 2011 May 20.
- Cryptococcus neoformans invades the central nerve system through endocytosis by the vascular endothelia. S100A10 interacts with Ca(2+) channel proteins in the vascular endothelia and regulates the filamentous actin network. We hypothesized that S100A10 was involved in the pathogenesis of cryptococco
- PMID 21621598
- Design, synthesis and antifungal activities of novel 1,2,4-triazole derivatives.
- Xu J, Cao Y, Zhang J, Yu S, Zou Y, Chai X, Wu Q, Zhang D, Jiang Y, Sun Q.SourceDepartment of Organic Chemistry, Second Military Medical University, Guohe Road 325, Shanghai 200433, People's Republic of China.
- European journal of medicinal chemistry.Eur J Med Chem.2011 Jul;46(7):3142-8. Epub 2011 Feb 24.
- A series of novel 1,2,4-triazole derivatives with a 4-(4-substitutedphenyl) piperazine side chain were designed and synthesized based on the structure of lanosterol 14α-demethylase (CYP51). Their antifungal activities against eight human pathogenic fungi were evaluated in vitro by measuring the min
- PMID 21420761
Japanese Journal
- クリプトコックス--莢膜多糖--結節(空洞)陰影 (特集 呼吸器病原体--病原因子--生体反応)
Related Links
- Cryptococcus neoformans is an encapsulated yeast that can live in both plants and animals. Its teleomorph is Filobasidiella neoformans, a filamentous fungus belonging to the class Tremellomycetes. It is often found in pigeon excrement. ...
Related Pictures
★リンクテーブル★
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- ラ
- Cryptococcus neoformans, C. neoformans
- 同
- Filobasidiella neoformans、クリプトコッカス・ネオフォルマンス
- 関
- クリプトコッカス症
- 厚い莢膜
- 不完全菌酵母
- 担子菌
- 感染組織内、培地でも莢膜を持つ単細胞(酵母)として増殖
- 中枢神経系に強い親和性を有する。
分布
- ミルク、加重、健常者の皮膚、消化管
- 土壌特にハトその他の鳥類、コアラの糞などで汚染された土壌に豊富に存在
分離培養
染色
感染症
- 感染経路は空気感染 → 肺クリプトコッカス症
- 細胞免疫能低下患者 → 髄膜や脳に二次感染
- HIV患者では高頻度にクリプトコッカス髄膜炎
参考
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- クリプトコッカス・ネオフォルマンス感染症、クリプトコッカス・ネオフォルマンス感染