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Wang J1, Yadav V1, Smart AL1, Tajiri S1, Basit AW2.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.Eur J Pharm Sci.2015 Oct 12;78:31-6. doi: 10.1016/j.ejps.2015.06.018. Epub 2015 Jun 23.
This study was the first to investigate the colonic stability of 17 peptide molecules (insulin, calcitonin, glucagon, secretin, somatostatin, desmopressin, oxytocin, Arg-vasopressin, octreotide, ciclosporin, leuprolide, nafarelin, buserelin, histrelin, [D-Ser(4)]-gonadorelin, deslorelin, and goserel
PMID 26111980

Toward oral delivery of biopharmaceuticals: an assessment of the gastrointestinal stability of 17 peptide drugs.

Wang J1, Yadav V, Smart AL, Tajiri S, Basit AW.
Molecular pharmaceutics.Mol Pharm.2015 Mar 2;12(3):966-73. doi: 10.1021/mp500809f. Epub 2015 Feb 10.
A major barrier to successful oral delivery of peptide and protein molecules is their inherent instability in the lumen of the gastrointestinal tract. The aim of this study was to determine the stability of 17 disparate peptide drugs (insulin, calcitonin, glucagon, secretin, somatostatin, desmopress
PMID 25612507

Brown J1, Farquhar C2.
JAMA.JAMA.2015 Jan 20;313(3):296-7. doi: 10.1001/jama.2014.17119.
CLINICAL QUESTION: What treatments are associated with improved outcomes for women with endometriosis BOTTOM LINE: The levonorgestrel-releasing intrauterine system (LNG-IUD), gonadotropin-releasing hormone analogues (GnRHa; nafarelin, leuprolide, buserelin, goserelin, triptorelin), laparoscopic abla
PMID 25603001

栗田郁,宮坂尚幸,吉田卓功,羅ことい,鬼塚真由美,田丸陽子,塚田貴史,後藤亮子,市川麻以子,遠藤誠一,坂本雅恵,島袋剛二
日本農村医学会雑誌 60(5), 627-630, 2012
　Gonadotropin-Releasing Hormone誘導体製剤 (以下，GnRHアナログ) は子宮内膜症に対する偽閉経療法として婦人科領域では広く使われている薬剤である。GnRHアナログ投与中は無月経状態となるので月経に伴う骨盤痛は回避できるが，更年期同様に低エストロゲン状態にさらされるので副作用として更年期症状を被る可能性がある。ほとんどの症例はGnRHアナログを中止する必要のない軽度 …
NAID 130004451246

伊藤真理子,高橋俊文,太田信彦,斉藤隆和,中原健次,斉藤英和,廣井正彦
日本不妊学会雑誌 = Japanese journal of fertility and sterility 43(3), 275-279, 1998-07-01
NAID 10008351966

Degradation of a Novel Tripeptide, tert-Butoxycarbonyl-Tyr-Leu-Val-CH_2Cl, with Inhibitory Effect on Human Leukocyte Elastase in Aqueous Solution and in Biological Fluids

Tokumitsu Hiroyuki,Fukumori Yoshinobu,Tsuda Yuko [他],OKADA Yoshio,KASUYA Fumiyo,IGARASHI Kazuo,FUKUI Miyoshi
Chemical & pharmaceutical bulletin 45(11), 1845-1850, 1997-11-15
… In the rat plasma, the half-life of YLV was 42.4 min (YLV 26.7 μg/ml plasma), and in rat liver, lung and spleen homogenates, the degradation rate constants of YLV were 37.6,10.3 and 23.5 times larger than that in plasma solution, respectively (all fluids containing 5 mg protein/ml).YLV was less stable than nafarelin acetate, secretin, adrenocorticotropic hormone (ACTH) and gonadorelin in an aqueous solution of pH 7.4. …
NAID 110003616453