Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/16 11:22:11」(JST)

wiki en

Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist). Its proposed mechanism of action is the desensitization of pituitary GnRH receptors leading to a decrease in gonadotropin release, and ovarian hormone serum concentrations similar to those achieved in postmenopausal women. it decreases pituitary secretion of the gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Nafarelin may be used in the treatment of estrogen-dependent conditions (such as endometriosis or uterine fibroids), to treat central precocious puberty, or to control ovarian stimulation in IVF.

Nafarelin acetate is marketed by Searle (now part of Pfizer) under the brand name Synarel. It is delivered via a nasal spray.

Side effects

Side effects of nafarelin are related to the low estrogen state. Side effects include hot flashes, vaginal dryness, headaches, mood changes, and decreased interest in sex. Some patients may experience acne, muscle pain, reduced breast size, and irritation of the tissue inside the nose. These side effects are reversible and should resolve after stopping the medication.^[1]

References

^ http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d0aa57cb-d2f4-46d7-af43-7c8b06aa81a6

3

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 子宮内膜症の長期治療を目的としたゴナドトロピン放出ホルモンアゴニスト gonadotropin releasing hormone agonists for long term treatment of endometriosis
2. アンドロゲン過剰症および男性型多毛症治療におけるGnRHアゴニストの使用 use of gnrh agonists in the treatment of hyperandrogenism and hirsutism
3. 思春期における子宮内膜症の診断および治療 diagnosis and treatment of endometriosis in adolescents
4. 性腺刺激ホルモン（ゴナドトロピン）放出ホルモンの生理学 physiology of gonadotropin releasing hormone
5. 成人女性における原発性月経困難症の治療 treatment of primary dysmenorrhea in adult women

English Journal

Spontaneous reports of seizure in association with leuprolide (lupron depot), goserelin (zoladex implant), and naferelin (synarel nasal spray).

Gatti J, Brinker A, Avigan M.
Obstetrics and gynecology.Obstet Gynecol.2013 May;121(5):1107. doi: 10.1097/AOG.0b013e31828c9cb3.
PMID 23635751

A mathematical model of the human menstrual cycle for the administration of GnRH analogues.

Röblitz S, Stötzel C, Deuflhard P, Jones HM, Azulay DO, van der Graaf PH, Martin SW.SourceComputational Systems Biology Group, Zuse Institute Berlin (ZIB), Berlin, Germany. susanna.roeblitz@zib.de
Journal of theoretical biology.J Theor Biol.2013 Mar 21;321:8-27. doi: 10.1016/j.jtbi.2012.11.020. Epub 2012 Dec 1.
The paper presents a differential equation model for the feedback mechanisms between gonadotropin-releasing hormone (GnRH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), development of follicles and corpus luteum, and the production of estradiol (E2), progesterone (P4), inhibin A (Ih
PMID 23206386

Restart of steroidogenesis in dogs during recrudescence of testicular function following downregulation with a GnRH-agonist implant.

Gentil M, Hoffmann B, Spang A, Failing K, Goericke-Pesch S.SourceClinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Justus-Liebig-University Giessen, Germany. schulzmichaela@gmx.de
Cell and tissue research.Cell Tissue Res.2012 Dec;350(3):513-23. doi: 10.1007/s00441-012-1506-5. Epub 2012 Oct 9.
To date, no details are available concerning the restart of steroidogenesis following the downregulation of testicular endocrine and germinative function by gonadotrophin-releasing hormone (GnRH)-agonist implants. This restart was assessed by determining the expression of steroidogenic acute regulat
PMID 23053053

Related Pictures

Synarel » Laboratorios SEID Synarel Prices, Coupons and Information Synarel - patient information, description SYNAREL 2 MG/ML NASAL SPRAY CON FINAL FELIZ: Synarel Synarel 200 mcg Synarel at PlanTheFam SYNAREL nosní sprej 1x 4ml

★リンクテーブル★

リンク元

「ナファレリン」

Nafarelin
Systematic (IUPAC) name
	(2R)-N-[(2R)-5-carbamimidamido-1-[(2S)-2-[(carbamoylmethyl)carbamoyl]pyrrolidin-1-yl]-1-oxopentan-2-yl]-2-[(2R)-2-[(2R)-2-[(2R)-3-hydroxy-2-[(2S)-2-[(2S)-3-(1H-imidazol-4-yl)-2-{[(2R)-5-oxopyrrolidin-2-yl]formamido}propanamido]-3-(1H-indol-3-yl)propanamido]propanamido]-3-(4-hydroxyphenyl)propanamido]-3-(naphthalen-2-yl)propanamido]-4-methylpentanamide
Clinical data
Trade names	Synarel
AHFS/Drugs.com	monograph
MedlinePlus	a601082
Pregnancy; category	X;
Legal status	℞ (Prescription only);
Routes of; administration	Nasal spray
Pharmacokinetic data
Half-life	2.6 to 4 hours
Excretion	renal
Identifiers
CAS Registry Number	76932-56-4
ATC code	H01CA02
PubChem	CID: 25077649
DrugBank	DB00666
ChemSpider	10482014
UNII	1X0094V6JV
ChEMBL	CHEMBL1201309
Chemical data
Formula	C66H83N17O13
Molecular mass	1321.6344 g/mol
	InChI InChI=1S/C66H83N17O13/c1-36(2)25-48(58(89)76-47(13-7-23-71-66(68)69)65(96)83-24-8-14-54(83)64(95)73-33-55(67)86)77-60(91)50(28-38-15-18-39-9-3-4-10-40(39)26-38)78-59(90)49(27-37-16-19-43(85)20-17-37)79-63(94)53(34-84)82-61(92)51(29-41-31-72-45-12-6-5-11-44(41)45)80-62(93)52(30-42-32-70-35-74-42)81-57(88)46-21-22-56(87)75-46/h3-6,9-12,15-20,26,31-32,35-36,46-54,72,84-85H,7-8,13-14,21-25,27-30,33-34H2,1-2H3,(H2,67,86)(H,70,74)(H,73,95)(H,75,87)(H,76,89)(H,77,91)(H,78,90)(H,79,94)(H,80,93)(H,81,88)(H,82,92)(H4,68,69,71)/t46-,47-,48-,49-,50+,51-,52-,53-,54-/m0/s1 ; Key:RWHUEXWOYVBUCI-ITQXDASVSA-N ;
(what is this?) (verify)

　　[★]

英: nafarelin
化: 酢酸ナファレリン nafarelin acetate
商: ナサニール、ナファレリール、Synarel
関: GnRHアゴニスト

ゴナドトロピン放出ホルモン誘導体;子宮内膜症治療薬

[1] ttp://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d0aa57cb-d2f4-46d7-af43-7c8b06aa81a6

匿名

検索

案内

案内

Synarel