WordNet

any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
of or relating to the spinal cord
of or relating to bone marrow
malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer (同)leukaemia, leucaemia, cancer of the blood
resembling lymph or lymphatic tissues

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1. 急性リンパ芽球性白血病における細胞遺伝学および分子遺伝学 cytogenetics and molecular genetics in acute lymphoblastic leukemia
2. 急性骨髄性白血病の病因 pathogenesis of acute myeloid leukemia
3. 小児および思春期における急性リンパ芽球性白血病のリスクグループ層別化および予後 risk group stratification and prognosis for acute lymphoblastic leukemia in children and adolescents
4. 急性骨髄性白血病の分子遺伝学 molecular genetics of acute myeloid leukemia
5. 急性骨髄性白血病の予後 prognosis of acute myeloid leukemia

GABP is necessary for stem/progenitor cell maintenance and myeloid differentiation in human hematopoiesis and chronic myeloid leukemia.

Manukjan G1, Ripperger T2, Venturini L3, Stadler M3, Göhring G2, Schambach A4, Schlegelberger B2, Steinemann D2.
Stem cell research.Stem Cell Res.2016 Apr 12;16(3):677-681. doi: 10.1016/j.scr.2016.04.007. [Epub ahead of print]
Maintenance of hematopoietic stem cells and their potential to give rise to progenitors of differentiated lymphoid and myeloid cells are accomplished by a network of regulatory processes. As a part of this network, the heteromeric transcription factor GA-binding protein (GABP) plays a crucial role i
PMID 27100840

Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1.

Gu S1, Chan WW2, Mohi G3, Rosenbaum J4, Sayad A5, Lu Z5, Virtanen C5, Li S6, Neel BG1, Van Etten RA2.
Blood.Blood.2016 Apr 7;127(14):1803-13. doi: 10.1182/blood-2015-06-653006. Epub 2016 Jan 15.
Tyrosine kinase inhibitors (TKIs) directed against BCR-ABL1, the product of the Philadelphia (Ph) chromosome, have revolutionized treatment of patients with chronic myeloid leukemia (CML). However, acquired resistance to TKIs is a significant clinical problem in CML, and TKI therapy is much less eff
PMID 26773044

Differential regulation of the c-Myc/Lin28 axis discriminates subclasses of rearranged MLL leukemia.

Chen L1, Sun Y1, Wang J1, Jiang H2, Muntean AG1.
Oncotarget.Oncotarget.2016 Mar 19. doi: 10.18632/oncotarget.8199. [Epub ahead of print]
MLL rearrangements occur in myeloid and lymphoid leukemias and are generally associated with a poor prognosis, however this varies depending on the fusion partner. We modeled acute myeloid leukemia (AML) in mice using various MLL fusion proteins (MLL-FPs) and observed significantly different surviva
PMID 27007052