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1. 水疱性類天疱瘡および粘膜類天疱瘡の臨床的特徴および診断clinical features and diagnosis of bullous pemphigoid and mucous membrane pemphigoid [show details]
…along the basement membrane zone is present in greater than 90 percent of cases ; less intense linear basement membrane zone staining for IgM, IgA, and/or IgE may be present. Mucous membrane pemphigoid – Linear …
2. 水疱性類天疱瘡および粘膜類天疱瘡の疫学および病因epidemiology and pathogenesis of bullous pemphigoid and mucous membrane pemphigoid [show details]
…epithelial basement membrane zone in skin and mucous membranes. Bullous pemphigoid antigen 180 (BP180) and bullous pemphigoid antigen 230 (BP230) are two principal basement membrane zone antigens targeted …
3. 粘膜類天疱瘡のマネージメントmanagement of mucous membrane pemphigoid [show details]
… Mucous membrane pemphigoid (MMP) is a rare, chronic, autoimmune, subepithelial blistering and erosive disease that affects the mucosal surfaces of the mouth (gingiva, movable mucosa, tongue, and palate) …
4. 皮膚の水疱を有する患者に対するアプローチapproach to the patient with cutaneous blisters [show details]
…cutaneous and mucosal findings : Mucous membrane pemphigoid – Mucous membrane pemphigoid (MMP) is defined as a diverse group of blistering disorders characterized by mucous membranes as the primary site of involvement …
5. 成人における全身性エリテマトーデスの臨床症状の概要overview of the clinical manifestations of systemic lupus erythematosus in adults [show details]
…and arthralgias in SLE are discussed in detail elsewhere. Most patients develop skin and mucous membrane lesions at some point during the course of their disease. There is tremendous variability in …

English Journal

Stable Tracheal Regeneration Using Organotypically Cultured Tissue Composed of Autologous Chondrocytes and Epithelial Cells in Beagles.

Sueyoshi S, Chitose SI, Sato K, Fukahori M, Kurita T, Umeno H.
The Annals of otology, rhinology, and laryngology. 2019 Jul;128(7)585-594.
In tracheal regeneration, the slow process of epithelialization is often a barrier to the stability and safety of the transplanted trachea. The aim of this study was to examine a new tracheal regeneration technique using organotypically cultured tissue composed of autologous cells. Nine beagles were
PMID 30832485

Strategizing biodegradable polymeric nanoparticles to cross the biological barriers for cancer targeting.

Choudhury H, Gorain B, Pandey M, Khurana RK, Kesharwani P.
International journal of pharmaceutics. 2019 Jun;565()509-522.
The biological barriers in the body have been fabricated by nature to protect the body from foreign molecules. The successful delivery of drugs is limited and being challenged by these biological barriers including the gastrointestinal tract, brain, skin, lungs, nose, mouth mucosa, and immune system
PMID 31102804

The maintenance of an oral epithelial barrier.

Wang SS, Tang YL, Pang X, Zheng M, Tang YJ, Liang XH.
Life sciences. 2019 Jun;227()129-136.
Oral epithelial barrier consists of closely controlled structure of the stratified squamous epithelium, which is the gateway to human bodies and encounters a huge burden of microbial, airborne and dietary antigens, as well as masticatory damage. Once this barrier is destroyed, it will trigger bone l
PMID 31002922

Japanese Journal

免疫抑制剤服用患者の舌に多発した膿原性肉芽腫の1例

下村都,山本一彦,柳生貴裕,下村忠弘,松末友美子,下村弘幸,桐田忠昭
日本口腔診断学会雑誌 31(3), 234-239, 2018
… Pyogenic granuloma is a non-neoplastic granulomatous lesion developing in skin and mucous membrane as the result of excessive tissue reaction. … The pathogenesis of this lesion remains obscure and differential diagnosis is often difficult. … We report a case of pyogenic granuloma that developed in a patient taking an immunosuppressant. …
NAID 130007499811

粘膜優位型尋常性天疱瘡の1例

雑賀太郎,兵行義,田所宏章,濱本真一,原浩貴
耳鼻咽喉科免疫アレルギー 36(3), 251-256, 2018
<p>【はじめに】尋常性天疱瘡は皮膚・粘膜に病変が認められる自己免疫性水疱性疾患であり，皮膚粘膜に疼痛を伴う難治性のびらん，潰瘍を認めるのが特徴である。初発症状として口腔粘膜症状の頻度が高く，難治性口腔病変として耳鼻咽喉科を受診することがある。今回我々は咽頭痛の増悪によって食事摂取困難を来たした粘膜優位型尋常性天疱瘡の1例を経験したので文献的考察を加えて報告する。</p>& …
NAID 130007492622

A Case of Stevens-Johnson Syndrome with Lesions Restricted to the Oropharyngolaryngeal Mucosa

Kaneda Misako,Tsukatani Toshiaki,Hasegawa Hiroki,Yoshizaki Tomokazu
耳鼻咽喉科臨床　補冊 151(0), 48-49, 2017
… <p>Stevens-Johnson syndrome (SJS) is a hypersensitivity reaction of the skin and mucosa to medications or infection. … Herein, we report the case of a 15-year-old boy with SJS who presented with mucous membrane lesions, but without skin lesions. … He had a one-week history of high fever prior to admission, and had been prescribed an antibiotic with an antipyretic-analgesic by his family doctor. …
NAID 130006235209