mitogen-activated protein kinase 14

マイトジェン活性化プロテインキナーゼ14

WordNet

1. aerate (sewage) so as to favor the growth of organisms that decompose organic matter (同)aerate
2. make (substances) radioactive
3. make active or more active; "activate an old file"
4. make more adsorptive; "activate a metal"
5. rendered active; e.g. rendered radioactive or luminescent or photosensitive or conductive
6. (of e.g. a molecule) made reactive or more reactive (同)excited
7. (military) set up and placed on active assignment; "a newly activated unit"
8. (of sewage) treated with aeration and bacteria to aid decomposition
9. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
10. an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
11. an agent that triggers mitosis

PrepTutorEJDIC

1. …'を'活動的にする / …‘に'放射能を与える / 〈物質〉'を'活性化する
2. 蛋白(たんばく)質

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/06/01 00:32:38」(JST)

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Main article: Mitogen-activated protein kinase

P38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation, apoptosis and autophagy.

p38 MAP Kinase (MAPK), also called RK or CSBP (Cytokinin Specific Binding Protein), is the mammalian orthologue of the yeast Hog1p MAP kinase, which participates in a signaling cascade controlling cellular responses to cytokines and stress.

Four p38 MAP kinases, p38-α (MAPK14), -β (MAPK11), -γ (MAPK12 / ERK6), and -δ (MAPK13 / SAPK4), have been identified. Similar to the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), Ultraviolet light, and growth factors.

mitogen-activated protein kinase 11 Identifiers Symbol MAPK11 Alt. symbols PRKM11 Entrez 5600 HUGO 6873 OMIM 602898 RefSeq NM_002751 UniProt Q15759 Other data EC number 2.7.11.24 Locus Chr. 22 q13.33	mitogen-activated protein kinase 12 Identifiers Symbol MAPK12 Alt. symbols SAPK3 Entrez 6300 HUGO 6874 OMIM 602399 RefSeq NM_002969 UniProt P53778 Other data EC number 2.7.11.24 Locus Chr. 22 q13.3
mitogen-activated protein kinase 13 Identifiers Symbol MAPK13 Alt. symbols PRKM13 Entrez 5603 HUGO 6875 OMIM 602899 RefSeq NM_002754 UniProt O15264 Other data EC number 2.7.11.24 Locus Chr. 6 p21	mitogen-activated protein kinase 14 Identifiers Symbol MAPK14 Alt. symbols CSPB1, CSBP1, CSBP2 Entrez 1432 HUGO 6876 OMIM 600289 RefSeq NM_001315 UniProt Q16539 Other data EC number 2.7.11.24 Locus Chr. 6 p21.3-21.2

MKK3 and SEK activate p38 MAP kinase by phosphorylation at Thr-180 and Tyr-182. Activated p38 MAP kinase has been shown to phosphorylate and activate MAPKAP kinase 2 and to phosphorylate the transcription factors ATF2, Mac and MEF2. p38 also has been shown to phosphorylate post-transcriptional regulating factors like TTP.

P38 inhibitors

P38 inhibitors are being sought for possible therapeutic effect on autoimmune diseases and inflammatory processes, e.g. pamapimod. Some have started clinical trials, e.g. PH-797804 for COPD. Other p38 inhibitors include BIRB 796, VX-702, SB 239063, SB202190, SCIO 469, and BMS 582949.

References

External links

• p38 Mitogen-Activated Protein Kinases at the US National Library of Medicine Medical Subject Headings (MeSH)
• P38mapkPathway
• p38 Signaling Pathway
• MAP Kinase Resource
• p38 MAPK Pathway

UpToDate Contents

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English Journal

• Mitogen-Activated Protein Kinase 14 Is a Novel Negative Regulatory Switch for the Vascular Smooth Muscle Cell Contractile Gene Program.

• Long X, Cowan SL, Miano JM.SourceDepartment of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY.
• Arteriosclerosis, thrombosis, and vascular biology.Arterioscler Thromb Vasc Biol.2012 Nov 21. [Epub ahead of print]
• OBJECTIVE: Several studies have shown through chemical inhibitors that p38 mitogen-activated protein kinase (MAPK) promotes vascular smooth muscle cell (VSMC) differentiation. Here, we evaluate the effects of knocking down a dominant p38MAPK isoform on VSMC differentiation.METHODS AND RESULTS: Knock
• PMID 23175675

• Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models.

• Chiacchiera F, Grossi V, Cappellari M, Peserico A, Simonatto M, Germani A, Russo S, Moyer MP, Resta N, Murzilli S, Simone C.SourceLaboratory of Signal-Dependent Transcription, Dept. of Translational Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro (CH) 66030, Italy. fulvio.chiacchiera@ieo.eu
• Cancer letters.Cancer Lett.2012 Nov 1;324(1):98-108. doi: 10.1016/j.canlet.2012.05.006. Epub 2012 May 11.
• We recently demonstrated that p38α is required to maintain colorectal cancer (CRC) metabolism, as its inhibition leads to FoxO3A activation, autophagy, cell death, and tumor growth reduction both in vitro and in vivo. Here we show that inhibition of p38α is followed by TRAIL-mediated activation of
• PMID 22579651

Japanese Journal

• Aberrant splicing of the hRasGRP4 transcript and decreased levels of this signaling protein in the peripheral blood mononuclear cells in a subset of patients with rheumatoid arthritis

• Hashimoto Toko,Yasuda Shinsuke,Koide Hideyuki,Kataoka Hiroshi,Horita Tetsuya,Atsumi Tatsuya,Koike Takao
• Arthritis Research & Therapy 13(5), R154, 2011-09-20
• … Introduction: An unidentified population of peripheral blood mononuclear cells (PBMCs) express Ras guanine nucleotide releasing protein 4 (RasGRP4). … Methods: Monocytes and T cells were purified from PBMCs of normal individuals, and were evaluated for their expression of RasGRP4 mRNA/protein. … RasGRP4 protein expression in PBMCs/monocytes was evaluated. … Results: Circulating CD14+ cells in normal individuals were found to express hRasGRP4. …
• NAID 120003945421

• Mitogen-Activated Protein Kinase Regulated by the CLAVATA Receptors Contributes to Shoot Apical Meristem Homeostasis

• BETSUYAKU Shigeyuki,TAKAHASHI Fuminori,KINOSHITA Atsuko,MIWA Hiroki,SHINOZAKI Kazuo,FUKUDA Hiroo,SAWA Shinichiro
• Plant and cell physiology 52(1), 14
• NAID 10029707603

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リンク元	「マイトジェン活性化プロテインキナーゼ14」
関連記事	「activated」「activate」「kinase」「protein kinase」

「マイトジェン活性化プロテインキナーゼ14」

　　[★]

英

mitogen-activated protein kinase 14

「activated」

　　[★]

• adj.

• 活性化の、活性化型の、賦活化の

関

activate、activated form、activation、turn on

　 　 　 　

「activate」

　　[★]

• v.

• 活性化する、賦活化する、賦活する

関

activated、activation、turn on

　 　 　 　 　

「kinase」

　　[★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase 　

「protein kinase」

　　[★] プロテインキナーゼ

同

protein kinases