mitogen-activated protein kinase 12

マイトジェン活性化プロテインキナーゼ12

WordNet

1. aerate (sewage) so as to favor the growth of organisms that decompose organic matter (同)aerate
2. make (substances) radioactive
3. make active or more active; "activate an old file"
4. make more adsorptive; "activate a metal"
5. rendered active; e.g. rendered radioactive or luminescent or photosensitive or conductive
6. (of e.g. a molecule) made reactive or more reactive (同)excited
7. (military) set up and placed on active assignment; "a newly activated unit"
8. (of sewage) treated with aeration and bacteria to aid decomposition
9. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
10. an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
11. an agent that triggers mitosis

PrepTutorEJDIC

1. …'を'活動的にする / …‘に'放射能を与える / 〈物質〉'を'活性化する
2. 蛋白(たんばく)質

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/16 21:10:47」(JST)

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Main article: Mitogen-activated protein kinase

P38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation, apoptosis and autophagy.

p38 MAP Kinase (MAPK), also called RK or CSBP (Cytokinin Specific Binding Protein), is the mammalian orthologue of the yeast Hog1p MAP kinase, which participates in a signaling cascade controlling cellular responses to cytokines and stress.

Four p38 MAP kinases, p38-α (MAPK14), -β (MAPK11), -γ (MAPK12 / ERK6), and -δ (MAPK13 / SAPK4), have been identified. Similar to the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), Ultraviolet light, and growth factors.

mitogen-activated protein kinase 11 Identifiers Symbol MAPK11 Alt. symbols PRKM11 Entrez 5600 HUGO 6873 OMIM 602898 RefSeq NM_002751 UniProt Q15759 Other data Locus Chr. 22 q13.33	mitogen-activated protein kinase 12 Identifiers Symbol MAPK12 Alt. symbols SAPK3 Entrez 6300 HUGO 6874 OMIM 602399 RefSeq NM_002969 UniProt P53778 Other data Locus Chr. 22 q13.3
mitogen-activated protein kinase 13 Identifiers Symbol MAPK13 Alt. symbols PRKM13 Entrez 5603 HUGO 6875 OMIM 602899 RefSeq NM_002754 UniProt O15264 Other data Locus Chr. 6 p21	mitogen-activated protein kinase 14 Identifiers Symbol MAPK14 Alt. symbols CSPB1, CSBP1, CSBP2 Entrez 1432 HUGO 6876 OMIM 600289 RefSeq NM_001315 UniProt Q16539 Other data Locus Chr. 6 p21.3-21.2

MKK3 and SEK activate p38 MAP kinase by phosphorylation at Thr-180 and Tyr-182. Activated p38 MAP kinase has been shown to phosphorylate and activate MAPKAP kinase 2 and to phosphorylate the transcription factors ATF2, Mac and MEF2. p38 also has been shown to phosphorylate post-transcriptional regulating factors like TTP.

P38 inhibitors

P38 inhibitors are being sought for possible therapeutic effect on autoimmune diseases and inflammatory processes, e.g. pamapimod. Some have started clinical trials, e.g. PH-797804 for COPD. Other p38 inhibitors include BIRB 796, VX-702, SB 239063, SCIO 469, and BMS 582949.

References

External links

• p38 Mitogen-Activated Protein Kinases at the US National Library of Medicine Medical Subject Headings (MeSH)
• P38mapkPathway
• p38 Signaling Pathway
• MAP Kinase Resource
• p38 MAPK Pathway

UpToDate Contents

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English Journal

• Exenatide Regulates Substrate Preferences Through the p38γ MAPK Pathway After Ischaemia/Reperfusion Injury in a Rat Heart.

• Zheng A1, Cao L1, Qin S1, Chen Y2, Li Y3, Zhang D4.
• Heart, lung & circulation.Heart Lung Circ.2017 Apr;26(4):404-412. doi: 10.1016/j.hlc.2016.07.006. Epub 2016 Aug 17.
• PMID 27574735

• Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ.

• Maisonneuve P1, Caillet-Saguy C2, Vaney MC3, Bibi-Zainab E2, Sawyer K2, Raynal B4, Haouz A5, Delepierre M2, Lafon M6, Cordier F2, Wolff N7.
• The Journal of biological chemistry.J Biol Chem.2016 Aug 5;291(32):16699-708. doi: 10.1074/jbc.M115.707208. Epub 2016 May 31.
• PMID 27246854

• Clinicopathological significance of p38β, p38γ, and p38δ and its biological roles in esophageal squamous cell carcinoma.

• Zheng S1,2, Yang C1,2, Liu T1,2, Liu Q1,2, Dai F1,2, Sheyhidin I2, Lu X3,4,5.
• Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.Tumour Biol.2016 Jun;37(6):7255-66. doi: 10.1007/s13277-015-4610-9. Epub 2015 Dec 14.
• PMID 26666822

Japanese Journal

• Potent Anti-inflammatory and Analgesic Actions of the Chloroform Extract of Dendropanax morbifera Mediated by the Nrf2/HO-1 Pathway

• Biological and Pharmaceutical Bulletin 39(5), 728-736, 2016
• NAID 130005149276

• Decreased hepatic phosphorylated p38 mitogen-activated protein kinase contributes to attenuation of thioacetamide-induced hepatic necrosis in diet-induced obese mice

• The Journal of Toxicological Sciences 41(2), 245-253, 2016
• NAID 130005132658

• Structure-activity relationship study of the neuritogenic potential of the glycan of starfish ganglioside LLG-3

• Marine Drugs 13(12
• NAID 120005756289

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リンク元	「マイトジェン活性化プロテインキナーゼ12」
関連記事	「activated」「activate」「kinase」「protein kinase」

「マイトジェン活性化プロテインキナーゼ12」

　　[★]

英

mitogen-activated protein kinase 12

「activated」

　　[★]

• adj.

• 活性化の、活性化型の、賦活化の

関

activate、activated form、activation、turn on

　 　 　 　

「activate」

　　[★]

• v.

• 活性化する、賦活化する、賦活する

関

activated、activation、turn on

　 　 　 　 　

「kinase」

　　[★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase 　

「protein kinase」

　　[★] プロテインキナーゼ

同

protein kinases