mitogen-activated protein kinase 11

マイトジェン活性化プロテインキナーゼ11

WordNet

1. aerate (sewage) so as to favor the growth of organisms that decompose organic matter (同)aerate
2. make (substances) radioactive
3. make active or more active; "activate an old file"
4. make more adsorptive; "activate a metal"
5. rendered active; e.g. rendered radioactive or luminescent or photosensitive or conductive
6. (of e.g. a molecule) made reactive or more reactive (同)excited
7. (military) set up and placed on active assignment; "a newly activated unit"
8. (of sewage) treated with aeration and bacteria to aid decomposition
9. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
10. an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
11. an agent that triggers mitosis

PrepTutorEJDIC

1. …'を'活動的にする / …‘に'放射能を与える / 〈物質〉'を'活性化する
2. 蛋白(たんばく)質

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/08/20 13:14:58」(JST)

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Main article: Mitogen-activated protein kinase

P38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation, apoptosis and autophagy. Persistent activation of the p38 MAPK pathway in muscle satellite cells (muscle stem cells) due to ageing, impairs muscle regeneration.

p38 MAP Kinase (MAPK), also called RK or CSBP (Cytokinin Specific Binding Protein), is the mammalian orthologue of the yeast Hog1p MAP kinase, which participates in a signaling cascade controlling cellular responses to cytokines and stress.

Four p38 MAP kinases, p38-α (MAPK14), -β (MAPK11), -γ (MAPK12 / ERK6), and -δ (MAPK13 / SAPK4), have been identified. Similar to the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), Ultraviolet light, and growth factors.

mitogen-activated protein kinase 11 Identifiers Symbol MAPK11 Alt. symbols PRKM11 Entrez 5600 HUGO 6873 OMIM 602898 RefSeq NM_002751 UniProt Q15759 Other data EC number 2.7.11.24 Locus Chr. 22 q13.33	mitogen-activated protein kinase 12 Identifiers Symbol MAPK12 Alt. symbols SAPK3 Entrez 6300 HUGO 6874 OMIM 602399 RefSeq NM_002969 UniProt P53778 Other data EC number 2.7.11.24 Locus Chr. 22 q13.3
mitogen-activated protein kinase 13 Identifiers Symbol MAPK13 Alt. symbols PRKM13 Entrez 5603 HUGO 6875 OMIM 602899 RefSeq NM_002754 UniProt O15264 Other data EC number 2.7.11.24 Locus Chr. 6 p21	mitogen-activated protein kinase 14 Identifiers Symbol MAPK14 Alt. symbols CSPB1, CSBP1, CSBP2 Entrez 1432 HUGO 6876 OMIM 600289 RefSeq NM_001315 UniProt Q16539 Other data EC number 2.7.11.24 Locus Chr. 6 p21.3-21.2

MKK3 and SEK activate p38 MAP kinase by phosphorylation at Thr-180 and Tyr-182. Activated p38 MAP kinase has been shown to phosphorylate and activate MAPKAP kinase 2 and to phosphorylate the transcription factors ATF2, Mac and MEF2. p38 also has been shown to phosphorylate post-transcriptional regulating factors like TTP.

P38 inhibitors

P38 inhibitors are being sought for possible therapeutic effect on autoimmune diseases and inflammatory processes, e.g. pamapimod. Some have started clinical trials, e.g. PH-797804 for COPD. Other p38 inhibitors include BIRB 796, VX-702, SB 239063, SB202190, SCIO 469, and BMS 582949. SB203580.

External links

• p38 Mitogen-Activated Protein Kinases at the US National Library of Medicine Medical Subject Headings (MeSH)
• P38mapkPathway
• p38 Signaling Pathway
• MAP Kinase Resource
• p38 MAPK Pathway

UpToDate Contents

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English Journal

• Rejuvenating aged muscle stem cells.

• Bentzinger CF1, Rudnicki MA2.
• Nature medicine.Nat Med.2014 Mar;20(3):234-5. doi: 10.1038/nm.3499.
• PMID 24603790

• p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice.

• Bernet JD1, Doles JD1, Hall JK2, Kelly Tanaka K1, Carter TA1, Olwin BB1.
• Nature medicine.Nat Med.2014 Mar;20(3):265-71. doi: 10.1038/nm.3465. Epub 2014 Feb 16.
• Skeletal muscle aging results in a gradual loss of skeletal muscle mass, skeletal muscle function and regenerative capacity, which can lead to sarcopenia and increased mortality. Although the mechanisms underlying sarcopenia remain unclear, the skeletal muscle stem cell, or satellite cell, is requir
• PMID 24531379

• Rejuvenation of the muscle stem cell population restores strength to injured aged muscles.

• Cosgrove BD1, Gilbert PM2, Porpiglia E1, Mourkioti F1, Lee SP1, Corbel SY1, Llewellyn ME3, Delp SL4, Blau HM1.
• Nature medicine.Nat Med.2014 Mar;20(3):255-64. doi: 10.1038/nm.3464. Epub 2014 Feb 16.
• The elderly often suffer from progressive muscle weakness and regenerative failure. We demonstrate that muscle regeneration is impaired with aging owing in part to a cell-autonomous functional decline in skeletal muscle stem cells (MuSCs). Two-thirds of MuSCs from aged mice are intrinsically defecti
• PMID 24531378

Japanese Journal

• Usefulness of serum 5-S-cysteinyl-dopa as a biomarker for predicting prognosis and detecting relapse in patients with advanced stage malignant melanoma

• Journal of Dermatology 44(4), 449-454, 2017-04
• NAID 120006366606

• Yin-yang regulating effects of cancer-associated genes, proteins, and cells: An ancient Chinese concept in vogue in modern cancer research

• BioScience Trends 11
• NAID 130006304492

• Effects of sorafenib and an adenylyl cyclase activator on <i>in vitro</i> growth of well-differentiated thyroid cancer cells

• Endocrine Journal 64(11
• NAID 130006225024

Related Links

• DrugBank: Mitogen-activated protein kinase 11

General Function Involved in MAP kinase activity Specific Function Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental ...

• Mitogen-activated protein kinase 11 - Homo sapiens (Human)

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リンク元	「マイトジェン活性化プロテインキナーゼ11」
関連記事	「activated」「activate」「kinase」「protein kinase」

「マイトジェン活性化プロテインキナーゼ11」

　　[★]

英

mitogen-activated protein kinase 11

「activated」

　　[★]

• adj.

• 活性化の、活性化型の、賦活化の

関

activate、activated form、activation、turn on

　 　 　 　

「activate」

　　[★]

• v.

• 活性化する、賦活化する、賦活する

関

activated、activation、turn on

　 　 　 　 　

「kinase」

　　[★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase 　

「protein kinase」

　　[★] プロテインキナーゼ

同

protein kinases