methyldopa

メチルドパ  

WordNet

  1. antihypertensive drug (trade name Aldomet) used in the treatment of high blood pressure (同)alpha methyl dopa, Aldomet

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/12/11 09:00:04」(JST)

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English Journal

  • An Eco-Friendly Direct Injection HPLC Method for Methyldopa Determination in Serum by Mixed-Mode Chromatography Using a Single Protein-Coated Column.
  • Emara S1, Masujima T2, Zarad W3, Kamal M4, Fouad M5, El-Bagary R5.
  • Journal of chromatographic science.J Chromatogr Sci.2015 Sep;53(8):1353-60. doi: 10.1093/chromsci/bmv024. Epub 2015 Apr 1.
  • A simple, rapid and environment-friendly direct injection HPLC method for the determination of methyldopa (MTD) in human serum has been developed and validated. The method was based on cleanup and separation of MTD from serum by mixed-mode liquid chromatography using a single protein-coated TSK gel
  • PMID 25834172
  • Salvianolic acid B as a substrate and weak catechol-O-methyltransferase inhibitor in rats.
  • Qi Q1, Cao L, Li F, Wang H, Liu H, Hao H, Hao K.
  • Xenobiotica; the fate of foreign compounds in biological systems.Xenobiotica.2015 Sep;45(9):820-7. doi: 10.3109/00498254.2015.1017753. Epub 2015 Jun 12.
  • 1. The aim of this study was to investigate the biotransformation of salvianolic acid B (SAB) by catechol-O-methyltransferase (COMT) and its interaction with levodopa (l-DOPA) methylation in rats. 2. The enzyme kinetics of SAB were studied after incubation with rat COMT. The in vivo SAB and 3-mo
  • PMID 25869243
  • Do labetalol and methyldopa have different effects on pregnancy outcome? Analysis of data from the Control of Hypertension In Pregnancy Study (CHIPS) trial.
  • Magee LA1,2,3; CHIPS Study Group, von Dadelszen P2,3, Singer J3,4, Lee T4, Rey E5, Ross S6, Asztalos E7,8,9, Murphy KE8,9, Menzies J2, Sanchez J9, Gafni A10, Gruslin A11, Helewa M12, Hutton E13, Koren G7, Lee SK7, Logan AG14, Ganzevoort JW15, Welch R16, Thornton JG17, Moutquin JM18.
  • BJOG : an international journal of obstetrics and gynaecology.BJOG.2015 Aug 11. doi: 10.1111/1471-0528.13569. [Epub ahead of print]
  • OBJECTIVE: To compare pregnancy outcomes, accounting for allocated group, between methyldopa-treated and labetalol-treated women in the CHIPS Trial (ISRCTN 71416914) of 'less tight' versus 'tight' control of pregnancy hypertension.DESIGN: Secondary analysis of CHIPS Trial cohort.SETTING: Internation
  • PMID 26265372

Japanese Journal

  • Induction of metamorphosis of pediveliger larvae of the mussel Mytilus galloprovincialis Lamarck, 1819 using neuroactive compounds, KCl, NH4Cl and organic solvents.
  • Yang Jin-Long,Satuito Cyril Glenn,Bao Wei-Yang,Kitamura Hitoshi
  • Biofouling 24(6), 461-470, 2008-08-12
  • … In 24-h exposure assays, alpha-methyldopa at 5 x 10(-5) M and methoxyphenamine at 5 x 10(-5)-10(-4) M induced 55-94% metamorphosis. …
  • NAID 120001779926
  • 硫酸マグネシウム大量投与とα-メチルドパの併用が有効であった重症破傷風の1例
  • 堀内 郁雄,藤原 晋次郎,森田 正則,石丸 剛,河野 匡彦,鈴木 幸一郎
  • 日本救急医学会雑誌 19(2), 113-118, 2008-02-15
  • NAID 10024371955
  • Modified high-performance liquid chromatography with electrochemical detection method for plasma measurement of levodopa, 3-O-methyldopa, dopamine, carbidopa and 3,4-dihydroxyphenyl acetic acid
  • KARIMI Morvarid,CARL Juanita L.,LOFTIN Susan,PERLMUTTER Joel S.
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 836(1), 120-123, 2006-05-19
  • NAID 10025783914

Related Links

Methyldopa (L-α-Methyl-3,4-dihydroxyphenylalanine; Aldomet, Aldoril, Dopamet, Dopegyt, etc.) is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive. Its use is ...
Methyldopa comes as a tablet and a liquid to take by mouth. It usually is taken two to four times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.



★リンクテーブル★
リンク元メチルドパ
拡張検索α-methyldopa

メチルドパ」

  [★]

methyldopa
methyldopi
αメチルドーパ αメチルドパ (国試)α-メチルドパ alpha-methyldopa
メチルドパ水和物
アルドメット Aldometユープレスドパ
血圧降下剤

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分類

  • 中枢性交感神経抑制薬

作用機序

  • α2受容体アゴニスト → シナプス前膜にあるα受容体に結合し、自己抑制的に作用するはず。
  • 血管運動中枢に抑制的に作用して、降圧に働く。

適応

  • 高血圧、妊婦、腎障害者に使用可能。妊婦にも使える降圧薬(ほかにヒドララジンがあったなあ)。

副作用

  • 溶血性貧血、SLE様作用、Coombs陽性、肝障害、起立性低血圧

GOO.853

  • 傾眠、見当識低下 ← 脳幹のα2受容体に対する作用
  • 口内乾燥 ← 延髄の中枢におけるα受容体の抑制。
  • 性欲減退、パーキンソン症候群、高プロラクチン血症(女性化乳房や乳汁漏出をきたすのが明白になる程度) ← 中枢神経系に対する作用(ドパミン作動性ニューロンにα-メチルドパミンが蓄積してそうである)
  • 洞房結節の機能障害がある患者では重度の徐脈や洞停止

禁忌

  • 肝障害

α-methyldopa」

  [★]

  • 内因性伝達物質の拮抗薬として働く
  • ノルエピネフリンに拮抗
  • 代謝によりα-methylepinephrineが生成する