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any substance involved in metabolism (either as a product of metabolism or as necessary for metabolism)

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代謝物質(新陳代謝によって生じる物質)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/07/25 12:01:42」(JST)

Metabolites are the intermediates and products of metabolism. The term metabolite is usually restricted to small molecules. Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, catalytic activity of their own (usually as a cofactor to an enzyme), defense, and interactions with other organisms (e.g. pigments, odorants, and pheromones). A primary metabolite is directly involved in normal "growth", development, and reproduction. Ethylene is an example of a primary metabolite produced in large-scale by industrial microbiology. A secondary metabolite is not directly involved in those processes, but usually has an important ecological function. Examples include antibiotics and pigments such as resins and terpenes etc. Some antibiotics use primary metabolites as precursors, such as actinomycin which is created from the primary metabolite, tryptophan. Some sugars that are metabolites; example: fructose or glucose in the metabolic pathways.

Examples of primary metabolites produced by industrial microbiology:^[1]

Class	Example
Alcohol	Ethanol
Amino acids	Glutamic acid, aspartic acid
Nucleotides	5' guanylic acid
Antioxidants	Isoascorbic acid
Organic acids	Acetic acid, lactic acid
Polyols	Glycerol
Vitamins	B₂

The metabolome forms a large network of metabolic reactions, where outputs from one enzymatic chemical reaction are inputs to other chemical reactions.

Metabolites from chemical compounds, whether inherent or pharmaceutical, are formed as part of the natural biochemical process of degrading and eliminating the compounds. The rate of degradation of a compound is an important determinant of the duration and intensity of its action. Profiling metabolites of pharmaceutical compounds, drug metabolism, is an important part of drug discovery, leading to an understanding of any undesirable side effects.

References

^ Demain, Arnold L. "Microbial Production of Primary Metabolites." MIT, 1980.

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1. 6-メルカプトプリン（6-MP）またはアザチオプリンを用いた炎症性腸疾患治療における6-MP代謝産物モニタリングおよびTPMT検査 6 mercaptopurine 6 mp metabolite monitoring and tpmt testing in the treatment of inflammatory bowel disease with 6 mp or azathioprine
2. 化学療法剤の腸管毒性 enterotoxicity of chemotherapeutic agents
3. 炎症性腸疾患におけるアザチオプリンおよび6-メルカプトプリン azathioprine and 6 mercaptopurine in inflammatory bowel disease
4. 肝臓の有機アニオン輸送能および薬物代謝能の検査 tests of the livers capacity to transport organic anions and metabolize drugs
5. 臨床的腎移植における研究中の免疫抑制剤およびそのアプローチ investigational immunosuppressive drugs and approaches in clinical kidney transplantation

English Journal

Epigenetic modifier induced enhancement of fumiquinazoline C production in Aspergillus fumigatus (GA-L7): an endophytic fungus from Grewia asiatica L.

Magotra A1,2, Kumar M1, Kushwaha M1, Awasthi P1, Raina C1, Gupta AP1, Shah BA3,4, Gandhi SG5,6, Chaubey A7,8.
AMB Express.AMB Express.2017 Dec;7(1):43. doi: 10.1186/s13568-017-0343-z. Epub 2017 Feb 17.
PMID 28213885

Test-retest reproducibility of [11C]-L-deprenyl-D2 binding to MAO-B in the human brain.

Arakawa R1, Stenkrona P2, Takano A2, Nag S2, Maior RS2,3, Halldin C2.
EJNMMI research.EJNMMI Res.2017 Dec;7(1):54. doi: 10.1186/s13550-017-0301-4. Epub 2017 Jun 20.
PMID 28634836

Assessment of endothelial cell function and physiological microcirculatory reserve by video microscopy using a topical acetylcholine and nitroglycerin challenge.

Hilty MP1, Pichler J2,3, Ergin B4, Hefti U5, Merz TM3, Ince C4, Maggiorini M6.
Intensive care medicine experimental.Intensive Care Med Exp.2017 Dec;5(1):26. doi: 10.1186/s40635-017-0139-0. Epub 2017 May 18.
PMID 28523563

Japanese Journal

FlavonoidSearch: A system for comprehensive flavonoid annotation by mass spectrometry.

Scientific reports 7, 2017-04-28
NAID 120006221993

Enzymatic oxidation of ellagitannin and a new ellagitannin metabolite from Camellia japonica leaves

Tetrahedron 73(5), 500-507, 2017-02-02
NAID 120006221110

Identification of a putative FR901469 biosynthesis gene cluster in fungal sp. No. 11243 and enhancement of the productivity by overexpressing the transcription factor gene frbF

Journal of bioscience and bioengineering 123(2), 147-153, 2017-02
NAID 40021112391

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★リンクテーブル★

リンク元	「代謝物」「代謝生成物」「代謝物質」「代謝産物」
拡張検索	「intermediary metabolite」「antimetabolite」「intermediate metabolite」「antineoplastic antimetabolite」

「代謝物」

　　[★]

英: metabolite
関: 代謝産物、代謝生成物

「代謝生成物」

　　[★]

英: metabolite
関: 代謝産物、代謝物

「代謝物質」

　　[★]

英: metabolite
関: 代謝

「代謝産物」

　　[★]

英: metabolite
関: 代謝

「intermediary metabolite」

　　[★]

中間代謝産物、中間代謝物、中間産物

関: intermediate metabolite、intermediate product

「antimetabolite」

　　[★]

代謝拮抗薬、代謝拮抗剤、抗代謝剤、代謝拮抗物質

関: metabolic antagonist

「intermediate metabolite」

　　[★]

中間代謝物

関: intermediary metabolite、intermediate product

「antineoplastic antimetabolite」

　　[★]

抗悪性腫瘍性代謝拮抗薬、抗悪性腫瘍性代謝拮抗剤

[test-1] Demain, Arnold L. "Microbial Production of Primary Metabolites." MIT, 1980.

[test-1] Demain, Arnold L. "Microbial Production of Primary Metabolites." MIT, 1980.

分類	例
アルコール	エタノール
アミノ酸	グルタミン酸、アスパラギン酸
核酸	5' グアニル酸
抗酸化物質	イソアスコルビン酸
有機酸	酢酸, 酪酸
ポリオール	グリセロール
ビタミン	B₂

匿名

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案内

案内

metabolite