WordNet

an antineoplastic drug that inhibits the utilization of a metabolite
a drug that neutralizes or counteracts the effects of another drug
a muscle that relaxes while another contracts; "when bending the elbow the triceps are the antagonist"
of or relating to metabolism; "metabolic rate"
undergoing metamorphosis (同)metabolous

PrepTutorEJDIC

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

AMP-kinase pathway is involved in tumor necrosis factor alpha-induced lipid accumulation in human hepatoma cells.

Lv Q1, Zhen Q1, Liu L1, Gao R2, Yang S1, Zhou H1, Goswami R1, Li Q3.
Life sciences.Life Sci.2015 Jun 15;131:23-9. doi: 10.1016/j.lfs.2015.03.003. Epub 2015 Mar 25.
AIM: It is well known that lipid accumulation and inflammation are two important steps in pathogenesis and progress of nonalcoholic fatty liver disease (NAFLD). However, fewer studies have explored the direct relationship between lipid accumulation and inflammation in early NAFLD. Tumor necrosis fac
PMID 25817233

Ammonium increases Ca2+ signalling and upregulates expression of Cav 1.2 gene in astrocytes in primary cultures and in the in vivo brain.

Wang F1, Du T1, Liang C1, Verkhratsky A2,3,4, Peng L1.
Acta physiologica (Oxford, England).Acta Physiol (Oxf).2015 Jun;214(2):261-274. doi: 10.1111/apha.12500. Epub 2015 Apr 18.
AIM: The primary aim of this study was to identify the effects of hyperammonaemia on functional expression of Cav 1.2 L-type Ca2+ channels in astroglia.METHODS: Primary cultures of mouse astrocytes were used to study effects of chronic treatment (1-5 days) with ammonium chloride, at 1, 3 and 5 mm
PMID 25846713

Boronic acid-containing CXCR1/2 antagonists: Optimization of metabolic stability, in vivo evaluation, and a proposed receptor binding model.

Maeda DY1, Peck AM2, Schuler AD2, Quinn MT3, Kirpotina LN3, Wicomb WN4, Auten RL5, Gundla R6, Zebala JA2.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2015 Jun 1;25(11):2280-4. doi: 10.1016/j.bmcl.2015.04.041. Epub 2015 Apr 23.
Blockade of undesired neutrophil migration to sites of inflammation remains an area of substantial pharmaceutical interest. To effect this blockade, a validated therapeutic target is antagonism of the chemokine receptor CXCR2. Herein we report the discovery of 6-(2-boronic acid-5-trifluoromethoxy-be
PMID 25933594

Effects of genistein in combination with conjugated estrogens on endometrial hyperplasia and metabolic dysfunction in ovariectomized mice

,
Endocrine Journal advpub(0), 2015
… It has been demonstrated that the phytoestrogen genistein (GEN) exhibits mixed estrogen receptor agonist and antagonist activity, suggesting that GEN may have potential for use as a natural SERM. … We evaluated, for the first time, the effects of GEN, conjugated estrogens (CE), and their pairing effects as a TSEC treatment on estrogen-induced endometrial hyperplasia and metabolic dysfunction in ovariectomized (OVX) mice fed a high-fat diet. …
NAID 130005064902

Calorie Restriction Improves Cognitive Decline via Up-Regulation of Brain-Derived Neurotrophic Factor:Tropomyosin-Related Kinase B in Hippocampus of Obesity-Induced Hypertensive Rats

, , , , , ,
International Heart Journal 56(1), 110-115, 2015
… In metabolic syndrome (MetS), previous studies have suggested that cognitive decline is worsened. … We divided dietary-induced obesity-prone and hypertensive rats (OP), as metabolic syndrome model rats, into three groups, fed with a high fat diet (HF), treated with calorie restriction (CR) plus vehicle, and treated with CR and ANA-12 (a TrkB antagonist) (CR+A). …
NAID 130004941290

田村奈渚,上野孝,尾見徳弥,川名誠司
日本医科大学医学会雑誌 10(1), 13-15, 2014
… Hydroxycarbamide, also known as hydroxyurea, is a nucleic-acid metabolic antagonist used to treat myeloproliferative disorders, such as chronic myelocytic leukemia, polycythemia vera, and essential thrombocythemia. …
NAID 130004941820