メナテトレノン
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/03/28 16:50:46」(JST)
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Menatetrenone
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Systematic (IUPAC) name |
2-methyl-3-[(2Z,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl]naphthoquinone |
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Pregnancy cat. |
? |
Legal status |
? |
Routes |
Oral |
Identifiers |
CAS number |
863-61-6 |
ATC code |
None |
PubChem |
CID 5282367 |
UNII |
27Y876D139 Y |
KEGG |
D00100 Y |
Synonyms |
3-methyl-2-[(2Z,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]naphthalene-1,4-dione |
Chemical data |
Formula |
C31H40O2 |
Mol. mass |
444.648 g/mol |
Y (what is this?) (verify)
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Menatetrenone (INN), also known as MK4, is a menaquinone compound used as a hemostatic agent and as adjunctive therapy for the pain of osteoporosis. It is marketed for the latter indication in Japan by Eisai Co., under the trade name Glakay.
Menatetrenone (MK4) is one of the nine forms of vitamin K2.[1]
See also
- Vitamin K
- Phylloquinone (vitamin K1)
References
- ^ Iwamoto J, Takeda T, Sato Y (December 2006). "Menatetrenone (vitamin K2) and bone quality in the treatment of postmenopausal osteoporosis". Nutr. Rev. 64 (12): 509–17. doi:10.1111/j.1753-4887.2006.tb00184.x. PMID 17274493. http://openurl.ingenta.com/content/nlm?genre=article&issn=0029-6643&volume=64&issue=12&spage=509&aulast=Iwamoto.
External links
- Product information: "Glakay" (PDF). Eisai Co.. November 2009. http://www.eisai.jp/medical/products/di/EPI/GLA_SC_EPI.pdf. Retrieved 2012-01-10.
Vitamins (A11)
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Fat soluble |
A
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α-Carotene · β-Carotene · Retinol# · Tretinoin
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D
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D2 (Ergosterol, Ergocalciferol#) · D3 (7-Dehydrocholesterol, Previtamin D3, Cholecalciferol, 25-hydroxycholecalciferol, Calcitriol (1,25-dihydroxycholecalciferol), Calcitroic acid) · D4 (Dihydroergocalciferol) · D5 · D analogues (Alfacalcidol, Dihydrotachysterol, Calcipotriol, Tacalcitol, Paricalcitol)
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E
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Tocopherol (Alpha, Beta, Gamma, Delta) · Tocotrienol (Alpha, Beta, Gamma, Delta) · Tocofersolan
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K
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Naphthoquinone · Phylloquinone (K1) · Menatetrenone (K2) · Menadione (K3) · Menadiol (K4)
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Water soluble |
B
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B1 (Thiamine#) · B2 (Riboflavin#) · B3 (Niacin, Nicotinamide#) · B5 (Pantothenic acid, Dexpanthenol, Pantethine) · B6 (Pyridoxine#, Pyridoxal phosphate, Pyridoxamine) · B7 (Biotin) · B9 (Folic acid, Dihydrofolic acid, Folinic acid) · B12 (Cyanocobalamin, Hydroxocobalamin, Methylcobalamin, Cobamamide) · Choline
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C
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Ascorbic acid# · Dehydroascorbic acid
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Combinations |
Multivitamins
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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noco, nuvi, sysi/epon, met
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UpToDate Contents
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English Journal
- The role of PKC isoforms in the inhibition of NF-κB activation by vitamin K2 in human hepatocellular carcinoma cells.
- Xia J, Matsuhashi S, Hamajima H, Iwane S, Takahashi H, Eguchi Y, Mizuta T, Fujimoto K, Kuroda S, Ozaki I.SourceDepartment of Internal Medicine, Saga Medical School, Saga University 5-1-1 Nabeshima, Saga 849-8501, Japan.
- The Journal of nutritional biochemistry.J Nutr Biochem.2012 Apr 2. [Epub ahead of print]
- Vitamin K (VK) has diverse protective effects against osteoporosis, atherosclerosis and carcinogenesis. We recently reported that menatetrenone, a VK2 analogue, suppressed nuclear factor (NF)-κB activation in human hepatoma cells. Although NF-κB is regulated by isoforms of protein kinase C (PKC),
- PMID 22475810
- [A case of a patient with bladder cancer who received warfarin and showed a significantly prolonged PT-INR after gemcitabine and cisplatin combination therapy].
- Yoshioka H, Kinoshita M, Ogawa M, Tsuruta T, Ozeki A, Morita A, Nomata K, Dakeshita H.SourceDept. of Pharmacy, Nagasaki Municipal Hospital, Japan.
- Gan to kagaku ryoho. Cancer & chemotherapy.Gan To Kagaku Ryoho.2012 Feb;39(2):321-3.
- A 74-year-old female patient with bladder cancer presented with edema in the right lower limb in a follow-up at the outpatient department.She was diagnosed with deep vein thrombosis in the right lower limb, and warfarin treatment was started.Subsequent gemcitabine and cisplatin combination(GC)therap
- PMID 22333653
Japanese Journal
- Vitamin K_2 Alters Bone Metabolism Markers in Hemodialysis Patients with a Low Serum Parathyroid Hormone Level
- Ochiai Mariko,Nakashima Ayumu,Takasugi Norihisa,Kiribayashi Kei,Kawai Toru,Usui Koji,Shigemoto Kenichiro,Hamaguchi Naoki,Kohno Nobuoki,Yorioka Noriaki,オチアイ マリコ,ナカシマ アユム,タカスギ ノリヒサ,キリバヤシ ケイ,カワイ トオル,ウスイ コウジ,シゲモト ケンイチロウ,ハマグチ ナオキ,コウノ ノブオキ,ヨリオカ ノリアキ,落合 真理子,中島 歩,高杉 敬久,桐林 慶,川合 徹,碓井 公治,重本 憲一郎,浜口 直樹,河野 修興,頼岡 徳在
- Nephron Clinical Practice 117(1), c15-c19, 2011
- … In this study, we assessed the efficacy of oral vitamin K2 in a controlled trial.Methods: Forty hemodialysis patients with low intact PTH levels (<100 pg/ml) were randomly divided into two groups, which were a vitamin K2 group receiving oral menatetrenone (45 mg/day) for 1 year and a control group without vitamin K2. …
- NAID 120002906882
- 後ろ向き観察研究による原発性骨粗鬆症に対するAlfacalcidol,MenatetrenoneならびにAlendronateによる治療法の検討
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Related Pictures
★リンクテーブル★
[★]
- 英
- menatetrenone
- 商
- グラケー、ケイツーN、ケイツー、ケーフイ、マルタミン
- 関
- ビタミンK。ビタミンK剤
- 活性型ビタミンK。
- 15mgカプセル 1回1カプセル 1日3回
- 骨粗鬆症の治療薬として用いられている。