WordNet

a complex consisting of an organic base in association with hydrogen chloride

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1. 過敏性腸症候群に対するアロセトロン塩酸塩（Lotronex） alosetron hydrochloride lotronex for irritable bowel syndrome
2. 早産児における非経口栄養 parenteral nutrition in premature infants
3. 変形性関節症の薬物療法に対する実験的アプローチ investigational approaches to the pharmacologic therapy of osteoarthritis
4. コーガン症候群 cogans syndrome
5. 局所麻酔剤に対するアレルギー反応 allergic reactions to local anesthetics

English Journal

Construction and performance characteristics of new ion selective electrodes based on carbon nanotubes for determination of meclofenoxate hydrochloride.

El-Nashar RM, Abdel Ghani NT, Hassan SM.SourceChemistry Department, Faculty of Science, Cairo University, Giza, Egypt. rasha.elnashar@guc.edu.eg
Analytica chimica acta.Anal Chim Acta.2012 Jun 12;730:99-111. Epub 2011 Nov 15.
This work offers construction and comparative evaluation the performance characteristics of conventional polymer (I), carbon paste (II) and carbon nanotubes chemically modified carbon paste ion selective electrodes (III) for meclofenoxate hydrochloride are described. These electrodes depend mainly o
PMID 22632051

[Studying specific effects of nootropic drugs on glutamate receptors in the rat brain].

Firstova IuIu, Vasil'eva EV, Kovalev GI.AbstractThe influence of nootropic drugs of different groups (piracetam, phenotropil, nooglutil, noopept, semax, meclofenoxate, pantocalcine, and dimebon) on the binding of the corresponding ligands to AMPA, NMDA, and mGlu receptors of rat brain has been studied by the method of radio-ligand binding in vitro. It is established that nooglutil exhibits pharmacologically significant competition with a selective agonist of AMPA receptors ([G-3H]Ro 48-8587) for the receptor binding sites (with IC50 = 6.4 +/- 0.2 microM), while the competition of noopept for these receptor binding sites was lower by an order of magnitude (IC50 = 80 +/- 5.6 microM). The heptapeptide drug semax was moderately competitive with [G-3H]LY 354740 for mGlu receptor sites (IC50 = 33 +/- 2.4 microM). Dimebon moderately influenced the specific binding of the ligand of NMDA receptor channel ([G-3H]MK-801) at IC50 = 59 +/- 3.6 microM. Nootropic drugs of the pyrrolidone group (piracetam, phenotropil) as well as meclofenoxate, pantocalcine (pantogam) in a broad rage of concentrations (10(-4)-10(-10) M) did not affect the binding of the corresponding ligands to glutamate receptors (IC50 100 pM). Thus, the direct neurochemical investigation was used for the first time to qualitatively characterize the specific binding sites for nooglutil and (to a lower extent) noopept on AMPA receptors, for semax on metabotropic glutamate receptors, and for dimebon on the channel region of NMDA receptors. The results are indicative of a selective action of some nootropes on the glutamate family.
Eksperimental'naia i klinicheskaia farmakologiia.Eksp Klin Farmakol.2011;74(1):6-10.
The influence of nootropic drugs of different groups (piracetam, phenotropil, nooglutil, noopept, semax, meclofenoxate, pantocalcine, and dimebon) on the binding of the corresponding ligands to AMPA, NMDA, and mGlu receptors of rat brain has been studied by the method of radio-ligand binding in vitr
PMID 21476267

Japanese Journal

Application of Microcalorimetry to Stability Testing of Meclofenoxate Hydrochloride and dl-α-Tocopherol

大塚知子,吉岡澄江,阿曽幸男,寺尾允男
Chemical & pharmaceutical bulletin 42(1), 130-132, 1994-01-15
… The hydrolysis of meclofenoxate hydrochloride and the oxidation of dl-α-tocopherol were chosen as model reactions. …
NAID 110003630756

pH-Dependent Degradation and Stabilization of Meclofenoxate Hydrochloride by Human Serum Albumin

太田直子,四ツ柳智久,池田憲
Chemical & pharmaceutical bulletin 34(6), 2585-2590, 1986-06-25
… The hydrolysis rate of meclofenoxate hydrochloride (MFX) was investigated in the absence and in the presence of human serum albumin (HSA). …
NAID 110003626430