関: meclofenoxate hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/30 07:10:18」(JST)

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Meclofenoxate (Lucidril), also known as centrophenoxine, is a drug used to treat the symptoms of senile dementia and Alzheimer's disease. It is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA). DMAE is a natural substance, found especially in fish. pCPA is a synthetic compound that resembles a variety of plant hormones called auxins.

In elderly patients, it has been clinically shown to improve memory, have a mentally stimulating effect, and improve general cognition.^[1] Meclofenoxate also increases cellular membrane phospholipids.^{[citation needed]}

It is also used off-label as a nootropic, often combined with a racetam drug such as piracetam.^{[citation needed]}

Side effects and contraindications

Meclofenoxate is generally considered safe. However possible side effects may include nausea or mild dizziness. People with severely high blood pressure or convulsive disorders such as epilepsy should avoid meclofenoxate.^[2]^{[unreliable source?]} Large doses may cause tight jaw clenching.

References

^ Marcer, D; Hopkins, SM (1977). "The differential effects of meclofenoxate on memory loss in the elderly". Age and ageing 6 (2): 123–31. doi:10.1093/ageing/6.2.123. PMID 329662.
^ Centrophenoxine Page @ The American Academy of Anti-Aging Medicine

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

English Journal

Aging of cell membranes: facts and theories.

Zs-Nagy I1.
Interdisciplinary topics in gerontology.Interdiscip Top Gerontol.2014;39:62-85. doi: 10.1159/000358900. Epub 2014 May 13.
This chapter is intended to outline the main results of a research trend realized by the author during the last 45 years, focused on the main role played by the cell membrane in the aging process. It is a very wide field; therefore, the reader cannot expect in this limited space a detailed descripti
PMID 24862015

Biolistic transformation of wheat with centrophenoxine as a synthetic auxin.

Ismagul A1, Iskakova G, Harris JC, Eliby S.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2014;1145:191-202. doi: 10.1007/978-1-4939-0446-4_15.
Cereal crops, including bread wheat (Triticum aestivum L.), are an important staple food worldwide. With a growing global population, it is evident that current crop production will not meet the rising demands being placed on modern agriculture. Efforts to improve crop yield and stress-tolerance by
PMID 24816669

Chromatographic behaviour predicts the ability of potential nootropics to permeate the blood-brain barrier.

Farsa O1.
Scientia pharmaceutica.Sci Pharm.2013 Mar;81(1):81-91. doi: 10.3797/scipharm.1208-19. Epub 2012 Oct 14.
The log BB parameter is the logarithm of the ratio of a compound's equilibrium concentrations in the brain tissue versus the blood plasma. This parameter is a useful descriptor in assessing the ability of a compound to permeate the blood-brain barrier. The aim of this study was to develop a Hansch-t
PMID 23641330

Japanese Journal

Crystal Structure of Meclofenoxate Hydrochloride

KAWAMURA Tomoko,HIRAYAMA Noriaki
X-ray Structure Analysis Online 25, 23-24, 2009
The crystal of the title compound, C12H16ClNO3·HCl, belongs to space group P1 with cell dimensions a = 7.1485(8), b = 13.919(2), c = 15.156(2)Å, α = 100.280(7), β = 101.783(7), and γ = 96.176(7)°. The …
NAID 130004544232

Application of Microcalorimetry to Stability Testing of Meclofenoxate Hydrochloride and dl-α-Tocopherol

大塚知子,吉岡澄江,阿曽幸男,寺尾允男
Chemical & pharmaceutical bulletin 42(1), 130-132, 1994-01-15
… The hydrolysis of meclofenoxate hydrochloride and the oxidation of dl-α-tocopherol were chosen as model reactions. …
NAID 110003630756

Application of Microcalorimetry to Stability Testing of Meclofenoxate Hydrochloride and dl-.ALPHA.-Tocopherol.

大塚知子,吉岡澄江,阿曽幸男,寺尾允男
ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 42(1), 130-132, 1994
… The hydrolysis of meclofenoxate hydrochloride and the oxidation of dl-α-tocopherol were chosen as model reactions. …
NAID 130003946408

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Meclofenoxate
Systematic (IUPAC) name
	2-Dimethylaminoethyl (4-chlorophenoxy)acetate
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	?
Identifiers
CAS number	51-68-3
ATC code	N06BX01
PubChem	CID 4039
ChemSpider	3899
UNII	C76QQ2I0RG
KEGG	D00993
Chemical data
Formula	C12H16ClNO3
Mol. mass	257.713
	SMILES Clc1ccc(OCC(=O)OCCN(C)C)cc1;
	InChI InChI=1S/C12H16ClNO3/c1-14(2)7-8-16-12(15)9-17-11-5-3-10(13)4-6-11/h3-6H,7-9H2,1-2H3; Key:XZTYGFHCIAKPGJ-UHFFFAOYSA-N ;
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