マトリックスメタロプロテアーゼ2、マトリックスメタロプロテイナーゼ2
- 関
- gelatinase A、MMP-2
WordNet
- (geology) amass of fine-grained rock in which fossils, crystals, or gems are embedded
- mold used in the production of phonograph records, type, or other relief surface
- the body substance in which tissue cells are embedded (同)intercellular substance, ground_substance
- (mathematics) a rectangular array of quantities or expressions set out by rows and columns; treated as a single element and manipulated according to rules
- an enclosure within which something originates or develops (from the Latin for womb)
- the formative tissue at the base of a nail
PrepTutorEJDIC
- (複数形 matrices, ~・es)(発生・成長の)母体 / 鋳型・模型;(レコードの)原盤;(活字の)母型,字母 / (金属・化石・宝石などの含んだ)母岩・《古》子宮・基盤; (細胞)細胞間質; (地学)基質; (印)字母; 紙型; 鋳型; (鉱)母岩; (数)行列; (コンピュータ)マトリックス (入力導線と出力導線の回路網); (言)母型文 (matrix sentence)
- マトリクシング(4チャンネルに再生転換できる2チャンネルの録音方式)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/10/16 21:51:19」(JST)
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Gelatinase A |
Identifiers |
EC number |
3.4.24.24 |
CAS number |
146480-35-5 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
|
Gelatinase A (EC 3.4.24.24, 72-kDa gelatinase, matrix metalloproteinase 2, type IV collagenase, 3/4 collagenase, matrix metalloproteinase 5, 72 kDa gelatinase type A, collagenase IV, collagenase type IV, MMP 2, type IV collagen metalloproteinase, type IV collagenase/gelatinase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln
This secreted endopeptidase belongs to the peptidase family M10.
References
- ^ Murphy, G., McAlpine, C.G., Poll, C.T. and Reynolds, J.J. (1985). "Purification and characterization of a bone metalloproteinase that degrades gelatin and types IV and V collagen". Biochim. Biophys. Acta 831: 49–58. doi:10.1016/0167-4838(85)90148-7. PMID 2994741.
- ^ Collier, I.E., Wilhelm, S.M., Eisen, A.Z., Marmer, B.L., Grant, G.A., Seltzer, J.L., Kronberger, A., He, C., Bauer, E.A. and Goldberg, G.I. (1988). "H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen". J. Biol. Chem. 263: 6579–6587. PMID 2834383.
- ^ Okada, Y., Morodomi, T., Enghild, J.J., Suzuki, K., Yasui, A., Nakanishi, I., Salvesen, G. and Nagase, H. (1990). "Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts-purification and activation of the precursor and enzymic properties". Eur. J. Biochem. 194: 721–730. doi:10.1111/j.1432-1033.1990.tb19462.x. PMID 2269296.
External links
- Gelatinase A at the US National Library of Medicine Medical Subject Headings (MeSH)
UpToDate Contents
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English Journal
- Decreased expression of the plasminogen activator inhibitor type 1 is involved in degradation of extracellular matrix surrounding cervical cancer stem cells.
- Sato M1, Kawana K1, Adachi K1, Fujimoto A1, Yoshida M1, Nakamura H1, Nishida H1, Inoue T1, Taguchi A1, Takahashi J1, Kojima S1, Yamashita A1, Tomio K1, Nagamatsu T1, Wada-Hiraike O1, Oda K1, Osuga Y1, Fujii T1.
- International journal of oncology.Int J Oncol.2016 Feb;48(2):829-35. doi: 10.3892/ijo.2015.3283. Epub 2015 Dec 9.
- The plasminogen activator (PA) system consists of plasminogen activator inhibitor type 1 (PAI-1), urokinase-type plasminogen activator and its receptor (uPA and uPAR). PAI-1 inhibits the activation of uPA (which converts plasminogen to plasmin), and is involved in cancer invasion and metastasis, by
- PMID 26676222
- miR-506 functions as a tumor suppressor in glioma by targeting STAT3.
- Peng T1, Zhou L1, Zuo L2, Luan Y1.
- Oncology reports.Oncol Rep.2016 Feb;35(2):1057-64. doi: 10.3892/or.2015.4406. Epub 2015 Nov 9.
- MicroRNA-506 (miR-506) has been reported to act as a tumor suppressive or an oncogenic miRNA in different types of tumors. However, the roles and underlying molecular mechanism of miR-506 in glioma remain unclear. In the present study, we performed quantitative PCR to investigate the level of miR-50
- PMID 26554866
- MMP2-Targeting and Redox-Responsive PEGylated Chlorin e6 Nanoparticles for Cancer Near-Infrared Imaging and Photodynamic Therapy.
- Hou W1,2, Xia F1, Alves CS3, Qian X1,2, Yang Y1, Cui D1.
- ACS applied materials & interfaces.ACS Appl Mater Interfaces.2016 Jan 20;8(2):1447-57. doi: 10.1021/acsami.5b10772. Epub 2016 Jan 5.
- A unique matrix metalloproteinase 2-targeted photosensitizer delivery platform was developed in this study for tumor-targeting imaging and photodynamic therapy. The model photosensitizer therapeutic agent chlorin e6 (Ce6) was first covalently conjugated with matrix metalloproteinase 2-cleavable poly
- PMID 26638778
Japanese Journal
- Shedding of kidney injury molecule-1 by membrane-type 1 matrix metalloproteinase
- Luyang Guo,Takahisa Takino,Yoshio Endo [他]
- The journal of biochemistry 152(5), 425-432, 2012-11
- NAID 40019507331
- HIF-1α Contributes to Hypoxia-induced Invasion and Metastasis of Esophageal Carcinoma via Inhibiting E-cadherin and Promoting MMP-2 Expression
- Jing Shao-Wu,Wang Ya-Di,Kuroda Masahiro,Su Jing-Wei,Sun Guo-Gui,Liu Qing,Cheng Yun-Jie,Yang Cong-Rong
- Acta Medica Okayama 66(5), 399-407, 2012-10
- … mRNA and protein expression of HIF-1α, E-cadherin and matrix metalloproteinase-2 (MMP-2) under hypoxia were detected by RT-PCR and Western blotting. …
- NAID 120004873436
- バイオマーカーによる高安動脈炎の診断と活動性の評価(3.動脈硬化のバイオマーカーの臨床的意義,<特集>第76回日本循環器学会学術集会)
Related Links
- マトリックスメタロプロテアーゼ(英:Matrix metalloproteinase、MMP)はメタロ プロテアーゼ(活性中心に金属イオンが配座しているタンパク質分解酵素の総称)の一群 でありMMPの活性中心には亜鉛イオン(Zn2+)が含まれる。コラーゲンや プロテオグリカン、 ...
Related Pictures
★リンクテーブル★
[★]
- 英
- matrix metalloproteinase 2、MMP-2
- 関
- マトリックスメタロプロテイナーゼ2
[★]
- 関
- matrix metalloproteinase 2
[★]
ゼラチナーゼA、ゲラチナーゼA
- 関
- matrix metalloproteinase 2
[★]
マトリックスメタロプロテアーゼ20
- 関
- enamelysin、MMP-20
[★]
マトリックスメタロプロテアーゼ MMP
[★]
メタロプロテアーゼ
[★]
メタロプロテアーゼ