matrix metalloproteinase 2

マトリックスメタロプロテアーゼ2、マトリックスメタロプロテイナーゼ2

関

gelatinase A、MMP-2

WordNet

1. (geology) amass of fine-grained rock in which fossils, crystals, or gems are embedded
2. mold used in the production of phonograph records, type, or other relief surface
3. the body substance in which tissue cells are embedded (同)intercellular substance, ground_substance
4. (mathematics) a rectangular array of quantities or expressions set out by rows and columns; treated as a single element and manipulated according to rules
5. an enclosure within which something originates or develops (from the Latin for womb)
6. the formative tissue at the base of a nail

PrepTutorEJDIC

1. （複数形 matrices, ～・es）(発生・成長の)母体 / 鋳型・模型;(レコードの)原盤;(活字の)母型,字母 / (金属・化石・宝石などの含んだ)母岩・《古》子宮・基盤; (細胞)細胞間質; (地学)基質; (印)字母; 紙型; 鋳型; (鉱)母岩; (数)行列; (コンピュータ)マトリックス (入力導線と出力導線の回路網); (言)母型文 （matrix sentence）
2. マトリクシング(4チャンネルに再生転換できる2チャンネルの録音方式)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/16 21:51:19」(JST)

wiki en

[Wiki en表示]

Gelatinase A
Identifiers
EC number	3.4.24.24
CAS number	146480-35-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Gelatinase A (EC 3.4.24.24, 72-kDa gelatinase, matrix metalloproteinase 2, type IV collagenase, 3/4 collagenase, matrix metalloproteinase 5, 72 kDa gelatinase type A, collagenase IV, collagenase type IV, MMP 2, type IV collagen metalloproteinase, type IV collagenase/gelatinase) is an enzyme. This enzyme catalyses the following chemical reaction

Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln

This secreted endopeptidase belongs to the peptidase family M10.

References

External links

• Gelatinase A at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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• 1. 腹部大動脈瘤の疫学、危険因子、病因および自然経過 epidemiology risk factors pathogenesis and natural history of abdominal aortic aneurysm
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• 5. 慢性閉塞性肺疾患（COPD）：危険因子およびリスク低減 chronic obstructive pulmonary disease risk factors and risk reduction

English Journal

• Decreased expression of the plasminogen activator inhibitor type 1 is involved in degradation of extracellular matrix surrounding cervical cancer stem cells.

• Sato M1, Kawana K1, Adachi K1, Fujimoto A1, Yoshida M1, Nakamura H1, Nishida H1, Inoue T1, Taguchi A1, Takahashi J1, Kojima S1, Yamashita A1, Tomio K1, Nagamatsu T1, Wada-Hiraike O1, Oda K1, Osuga Y1, Fujii T1.
• International journal of oncology.Int J Oncol.2016 Feb;48(2):829-35. doi: 10.3892/ijo.2015.3283. Epub 2015 Dec 9.
• The plasminogen activator (PA) system consists of plasminogen activator inhibitor type 1 (PAI-1), urokinase-type plasminogen activator and its receptor (uPA and uPAR). PAI-1 inhibits the activation of uPA (which converts plasminogen to plasmin), and is involved in cancer invasion and metastasis, by
• PMID 26676222

• miR-506 functions as a tumor suppressor in glioma by targeting STAT3.

• Peng T1, Zhou L1, Zuo L2, Luan Y1.
• Oncology reports.Oncol Rep.2016 Feb;35(2):1057-64. doi: 10.3892/or.2015.4406. Epub 2015 Nov 9.
• MicroRNA-506 (miR-506) has been reported to act as a tumor suppressive or an oncogenic miRNA in different types of tumors. However, the roles and underlying molecular mechanism of miR-506 in glioma remain unclear. In the present study, we performed quantitative PCR to investigate the level of miR-50
• PMID 26554866

• MMP2-Targeting and Redox-Responsive PEGylated Chlorin e6 Nanoparticles for Cancer Near-Infrared Imaging and Photodynamic Therapy.

• Hou W1,2, Xia F1, Alves CS3, Qian X1,2, Yang Y1, Cui D1.
• ACS applied materials & interfaces.ACS Appl Mater Interfaces.2016 Jan 20;8(2):1447-57. doi: 10.1021/acsami.5b10772. Epub 2016 Jan 5.
• A unique matrix metalloproteinase 2-targeted photosensitizer delivery platform was developed in this study for tumor-targeting imaging and photodynamic therapy. The model photosensitizer therapeutic agent chlorin e6 (Ce6) was first covalently conjugated with matrix metalloproteinase 2-cleavable poly
• PMID 26638778

Japanese Journal

• Shedding of kidney injury molecule-1 by membrane-type 1 matrix metalloproteinase

• Luyang Guo,Takahisa Takino,Yoshio Endo [他]
• The journal of biochemistry 152(5), 425-432, 2012-11
• NAID 40019507331

• HIF-1α Contributes to Hypoxia-induced Invasion and Metastasis of Esophageal Carcinoma via Inhibiting E-cadherin and Promoting MMP-2 Expression

• Jing Shao-Wu,Wang Ya-Di,Kuroda Masahiro,Su Jing-Wei,Sun Guo-Gui,Liu Qing,Cheng Yun-Jie,Yang Cong-Rong
• Acta Medica Okayama 66(5), 399-407, 2012-10
• … mRNA and protein expression of HIF-1α, E-cadherin and matrix metalloproteinase-2 (MMP-2) under hypoxia were detected by RT-PCR and Western blotting. …
• NAID 120004873436

• バイオマーカーによる高安動脈炎の診断と活動性の評価(3.動脈硬化のバイオマーカーの臨床的意義,<特集>第76回日本循環器学会学術集会)

• 石原 卓,磯部 光章
• 循環器専門医 : 日本循環器学会専門医誌 20(2), 245-249, 2012-09-25
• NAID 110009518489

Related Links

• マトリックスメタロプロテアーゼ - Wikipedia

マトリックスメタロプロテアーゼ(英:Matrix metalloproteinase、MMP)はメタロ プロテアーゼ(活性中心に金属イオンが配座しているタンパク質分解酵素の総称)の一群 でありMMPの活性中心には亜鉛イオン(Zn2+)が含まれる。コラーゲンや プロテオグリカン、 ...

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★リンクテーブル★

リンク元	「マトリックスメタロプロテアーゼ2」「MMP-2」「gelatinase A」
拡張検索	「matrix metalloproteinase 20」
関連記事	「matrix metalloproteinase」「metalloproteinase」「metalloproteinases」

「マトリックスメタロプロテアーゼ2」

　　[★]

英

matrix metalloproteinase 2、MMP-2

関

マトリックスメタロプロテイナーゼ2

「MMP-2」

　　[★]

• マトリックスメタロプロテアーゼ2

関

matrix metalloproteinase 2

「gelatinase A」

　　[★]

ゼラチナーゼA、ゲラチナーゼA

関

matrix metalloproteinase 2

「matrix metalloproteinase 20」

　　[★]

マトリックスメタロプロテアーゼ20

関

enamelysin、MMP-20

「matrix metalloproteinase」

　　[★] マトリックスメタロプロテアーゼ MMP

「metalloproteinase」

　　[★] メタロプロテアーゼ

「metalloproteinases」

　　[★] メタロプロテアーゼ