ゼラチナーゼA、ゲラチナーゼA
- 関
- matrix metalloproteinase 2
WordNet
- the 1st letter of the Roman alphabet (同)a
- the blood group whose red cells carry the A antigen (同)type_A, group A
PrepTutorEJDIC
- answer / ampere
- arsenicの化学記号
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/10 08:10:03」(JST)
[Wiki en表示]
| Gelatinase A |
| Identifiers |
| EC number |
3.4.24.24 |
| CAS number |
146480-35-5 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
Gelatinase A (EC 3.4.24.24, 72-kDa gelatinase, matrix metalloproteinase 2, type IV collagenase, 3/4 collagenase, matrix metalloproteinase 5, 72 kDa gelatinase type A, collagenase IV, collagenase type IV, MMP 2, type IV collagen metalloproteinase, type IV collagenase/gelatinase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln
This secreted endopeptidase belongs to the peptidase family M10.
References
- ^ Murphy, G., McAlpine, C.G., Poll, C.T. and Reynolds, J.J. (1985). "Purification and characterization of a bone metalloproteinase that degrades gelatin and types IV and V collagen". Biochim. Biophys. Acta 831: 49–58. doi:10.1016/0167-4838(85)90148-7. PMID 2994741.
- ^ Collier, I.E., Wilhelm, S.M., Eisen, A.Z., Marmer, B.L., Grant, G.A., Seltzer, J.L., Kronberger, A., He, C., Bauer, E.A. and Goldberg, G.I. (1988). "H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen". J. Biol. Chem. 263: 6579–6587. PMID 2834383.
- ^ Okada, Y., Morodomi, T., Enghild, J.J., Suzuki, K., Yasui, A., Nakanishi, I., Salvesen, G. and Nagase, H. (1990). "Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts-purification and activation of the precursor and enzymic properties". Eur. J. Biochem. 194: 721–730. doi:10.1111/j.1432-1033.1990.tb19462.x. PMID 2269296.
External links
- Gelatinase A at the US National Library of Medicine Medical Subject Headings (MeSH)
UpToDate Contents
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English Journal
- The role of Duffy antigen receptor for chemokines in keloids.
- Chen Y1, Liao N2, Lu F3, Peng H4, Gao J5.
- Gene.Gene.2015 Oct 1;570(1):44-9. doi: 10.1016/j.gene.2015.05.071. Epub 2015 Jun 2.
- This study aims to determine the relationship between Duffy antigen receptor for chemokines (DARC) and keloid pathogenesis. DARC expression was determined by immunohistochemistry, real-time PCR, and Western blot analysis. Cell proliferation was assessed by CCK-8 assay. Cell migration and invasion ab
- PMID 26045366
- A colorimetric-based amplification system for proteinases including MMP2 and ADAM8.
- Moss ML1, Koller G2, Bartsch JW3, Rakow S3, Schlomann U3, Rasmussen FH4.
- Analytical biochemistry.Anal Biochem.2015 Sep 1;484:75-81. doi: 10.1016/j.ab.2015.05.011. Epub 2015 May 27.
- We have developed a new amplification system for proteinases that is sensitive, simple, and inexpensive to run, exemplified by a horseradish peroxidase (HRP)-conjugated, dual MMP2 (matrix metalloproteinase 2) and ADAM8 (a disintegrin and metalloproteinase 8) peptide substrate assay presented herein.
- PMID 26026386
- Enhancing cancer targeting and anticancer activity by a stimulus-sensitive multifunctional polymer-drug conjugate.
- Tu Y1, Zhu L2.
- Journal of controlled release : official journal of the Controlled Release Society.J Control Release.2015 Aug 28;212:94-102. doi: 10.1016/j.jconrel.2015.06.024. Epub 2015 Jun 22.
- Undesirable physicochemical properties, low tumor targeting, insufficient cell internalization, acquired drug resistance, and severe side effects significantly limit the applications of anticancer drugs. In this study, to improve the tumor targeting and drug efficacy of the poorly water-soluble drug
- PMID 26113423
Japanese Journal
- 腎機能障害合併例(透析導入前高度腎不全と透析導入例)に対する心臓外科手術 (特集 合併症を有する胸部外科手術) -- (心臓血管領域)
- Neutrophil gelatinase-associated lipocalin (NGAL) in inflammatory bowel disease : association with pathophysiology of inflammation, established markers, and disease activity
- OIKONOMOU K. A.,KAPSORITAKIS A. N.,THEODORIDOU C.,KARANGELIS D.,GERMENIS A.,STEFANIDIS I.,POTAMIANOS S. P.
- Journal of gastroenterology 47(5), 519-530, 2012-05-01
- NAID 10030650504
- Plasma neutrophil gelatinase-associated lipocalin clearance during venovenous hemodiafiltration
- IGUCHI Naoya,UCHIYAMA Akinori,HOSOTSUBO Kikumi,FUJINO Yuji
- Clinical and experimental nephrology 16(2), 356-357, 2012-04-01
- NAID 10030739234
Related Links
- GeneTex社の MMP2 [A-Gel VC2]抗体(Anti-MMP2 [A-Gel VC2] | MMP2 [A-Gel VC2] antibody | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase))です。※本製品は研究目的にのみ販売して ...
- Activation of Latent TGF-β1 by Gelatinase A Eighty percent confluent cultures of NRK-52e cells were incubated with the indicated concentrations of active gelatinase A for 3 days in Optimem (Invitrogen, Carlsbad, CA).
★リンクテーブル★
[★]
マトリックスメタロプロテアーゼ2、マトリックスメタロプロテイナーゼ2
- 関
- gelatinase A、MMP-2
[★]
- 英
- gelatinase A
- 関
- ゼラチナーゼA、マトリックスメタロプロテイナーゼ2
[★]
- 英
- gelatinase A
- 関
- ゲラチナーゼA
[★]
[★]
- 関
- adenoviral、adenovirus
[★]
ゼラチナーゼ、ゲラチナーゼ