English Journal

Mechanical forces induce odontoblastic differentiation of mesenchymal stem cells on three-dimensional biomimetic scaffolds.

Miyashita S1, El Motaz Bellah NA, Murakami M, Iohara K, Yamamoto T, Horibe H, Kurita K, Takano-Yamamoto T, Nakashima M.
Journal of tissue engineering and regenerative medicine.J Tissue Eng Regen Med.2014 Jun 12. doi: 10.1002/term.1928. [Epub ahead of print]
The mechanical induction of cell differentiation is well known. However, the effect of mechanical compression on odontoblastic differentiation remains to be elucidated. Thus, we first determined the optimal conditions for the induction of human dental pulp stem cells (hDPSCs) into odontoblastic diff
PMID 24920062

Genetic comparisons yield insight into the evolution of enamel thickness during human evolution.

Horvath JE1, Ramachandran GL2, Fedrigo O3, Nielsen WJ4, Babbitt CC5, St Clair EM2, Pfefferle LW4, Jernvall J6, Wray GA7, Wall CE8.
Journal of human evolution.J Hum Evol.2014 May 5. pii: S0047-2484(14)00088-8. doi: 10.1016/j.jhevol.2014.01.005. [Epub ahead of print]
Enamel thickness varies substantially among extant hominoids and is a key trait with significance for interpreting dietary adaptation, life history trajectory, and phylogenetic relationships. There is a strong link in humans between enamel formation and mutations in the exons of the four genes that
PMID 24810709

Extracts of irradiated mature human tooth crowns contain MMP-20 protein and activity.

McGuire JD1, Mousa AA1, Zhang BJ1, Todoki LS1, Huffman NT1, Chandrababu KB2, Moradian-Oldak J2, Keightley A3, Wang Y1, Walker MP1, Gorski JP4.
Journal of dentistry.J Dent.2014 May;42(5):626-35. doi: 10.1016/j.jdent.2014.02.013. Epub 2014 Mar 4.
OBJECTIVES: We recently demonstrated a significant correlation between enamel delamination and tooth-level radiation dose in oral cancer patients. Since radiation can induce the synthesis and activation of matrix metalloproteinases, we hypothesized that irradiated teeth may contain active matrix met
PMID 24607847

Japanese Journal

FUKAE Makoto
Journal of oral biosciences 51(1), 46-60, 2009-02-20
… In porcine secretory enamel, mineral volume increases with depth, gaining space for thickening the existing crystallites by shrinking amelogenin micelles through the removal of C-terminal and 13-kDa peptides from the prototype 25-kDa amelogenin, the most abundant porcine amelogenin gene product, by the action of enamelysin (MMP-20) and enamel matrix serine proteinase (EMSP1), respectively.During the secretory stage, the crystallites thicken in the deeper secretory enamel, although calcium ions are supplied by ameloblasts. …
NAID 10027104448

PAPAGERAKIS P.,LIN H.-K.,LEE K. Y.,HU Y.,SIMMER J. P.,BARTLETT J. D.,HU J. C.-C.
Journal of dental research 87(1), 56-59, 2008-01-01
NAID 10021995594

IWATA T.,YAMAKOSHI Y.,HU J. C.-C.,ISHIKAWA I.,BARTLETT J. D.,KREBSBACH P. H.,SIMMER J. P.
Journal of dental research 86(2), 153-157, 2007-02-01
NAID 10024438730