matrix metalloproteinase 1

マトリックスメタロプロテアーゼ1、マトリックスメタロプロテイナーゼ1

関

interstitial collagenase、MMP-1

WordNet

1. (geology) amass of fine-grained rock in which fossils, crystals, or gems are embedded
2. mold used in the production of phonograph records, type, or other relief surface
3. the body substance in which tissue cells are embedded (同)intercellular substance, ground_substance
4. (mathematics) a rectangular array of quantities or expressions set out by rows and columns; treated as a single element and manipulated according to rules
5. an enclosure within which something originates or develops (from the Latin for womb)
6. the formative tissue at the base of a nail

PrepTutorEJDIC

1. （複数形 matrices, ～・es）(発生・成長の)母体 / 鋳型・模型;(レコードの)原盤;(活字の)母型,字母 / (金属・化石・宝石などの含んだ)母岩・《古》子宮・基盤; (細胞)細胞間質; (地学)基質; (印)字母; 紙型; 鋳型; (鉱)母岩; (数)行列; (コンピュータ)マトリックス (入力導線と出力導線の回路網); (言)母型文 （matrix sentence）
2. マトリクシング(4チャンネルに再生転換できる2チャンネルの録音方式)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/04/16 19:50:33」(JST)

wiki en

[Wiki en表示]

Interstitial collagenase
collagenase monomer, Human fibroblast
Identifiers
EC number	3.4.24.7
CAS number	2593923
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Interstitial collagenase (EC 3.4.24.7, vertebrate collagenase, matrix metalloproteinase 1) is an enzyme. This enzyme catalyses the following chemical reaction

Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly⁷⁷⁵-Ile in the alpha1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue

This enzyme belongs to the peptidase family M10.

See also

• Collagenase

References

External links

• Interstitial collagenase at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 肝線維症の病因 pathogenesis of hepatic fibrosis
• 2. 変形性関節症の病因 pathogenesis of osteoarthritis
• 3. UVA1療法 uva1 phototherapy
• 4. 研究用生物学的マーカーによる関節リウマチの診断および評価ま investigational biologic markers in the diagnosis and assessment of rheumatoid arthritis
• 5. 咽喉頭逆流 laryngopharyngeal reflux

English Journal

• Phenolic-rich extract from the Costa Rican guava (Psidium friedrichsthalianum) pulp with antioxidant and anti-inflammatory activity. Potential for COPD therapy.

• Flores G, Dastmalchi K, Wu SB, Whalen K, Dabo AJ, Reynertson KA, Foronjy RF, D Armiento JM, Kennelly EJ.SourceDepartment of Biological Sciences, Lehman College and the Graduate Center, City University of New York, 250 Bedford Park Boulevard West, Bronx, NY 10468, USA; Instituto de Fermentaciones Industriales, Consejo Superior de Investigaciones Científicas (CSIC), c/Juan de la Cierva 3, 28006 Madrid, Spain.
• Food chemistry.Food Chem.2013 Nov 15;141(2):889-95. doi: 10.1016/j.foodchem.2013.03.025. Epub 2013 Mar 16.
• The potential therapeutic effects of Costa Rican guava (Psidium friedrichsthalianum) extracts for chronic obstructive pulmonary disease were examined. The ethyl acetate fraction displayed the highest antioxidant activity, as compared to the hexane, chloroform, and n-butanol fractions, as well as the
• PMID 23790863

• Expression of catalytically active matrix metalloproteinase-1 in dermal fibroblasts induces collagen fragmentation and functional alterations that resemble aged human skin.

• Xia W, Hammerberg C, Li Y, He T, Quan T, Voorhees JJ, Fisher GJ.SourceDepartment of Dermatology, University of Michigan, 1301 E Catherine, R6447 Med Sci I, Ann Arbor, MI 48109-5609, USA.
• Aging cell.Aging Cell.2013 Aug;12(4):661-71. doi: 10.1111/acel.12089. Epub 2013 May 15.
• Increased expression of matrix metalloproteinase-1 (MMP-1) and reduced production of type I collagen by dermal fibroblasts are prominent features of aged human skin. We have proposed that MMP-1-mediated collagen fibril fragmentation is a key driver of age-related decline of skin function. To investi
• PMID 23601157

• Toll-like receptor-mediated, enhanced production of profibrotic TIMP-1 in monocytes from patients with systemic sclerosis: role of serum factors.

• Ciechomska M, Huigens CA, Hügle T, Stanly T, Gessner A, Griffiths B, Radstake TR, Hambleton S, O'Reilly S, van Laar JM.SourceMusculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, , Newcastle upon Tyne, UK.
• Annals of the rheumatic diseases.Ann Rheum Dis.2013 Aug;72(8):1382-9. doi: 10.1136/annrheumdis-2012-201958. Epub 2012 Dec 6.
• OBJECTIVES: To investigate whether monocytes contribute to matrix deposition in systemic sclerosis (SSc) by production of tissue-inhibitor of metalloproteinase-1 (TIMP-1).METHODS: Matrix metalloproteinase-1 (MMP-1) and TIMP-1 expression and secretion were measured by qRT-PCR and ELISA in circulating
• PMID 23223421

Japanese Journal

• 呼吸器ウイルス感染による気道リモデリングの機序 (特集 呼吸器ウイルス感染症と乳幼児喘鳴および気管支喘息)

• 市川 朋宏
• 臨床免疫・アレルギー科 63(4), 356-361, 2015-04
• NAID 40020444966

• Regorafenib suppresses sinusoidal obstruction syndrome in rats.

• Okuno Masayuki,Hatano Etsuro,Nakamura Kojiro,Miyagawa-Hayashino Aya,Kasai Yosuke,Nishio Takahiro,Seo Satoru,Taura Kojiro,Uemoto Shinji
• The Journal of surgical research 193(2), 693-703, 2015-02
• … Regorafenib reduced the phosphorylation of extracellular signal-regulated kinase, which induced matrix metalloproteinase-9 (MMP-9) activation and decreased the activity of MMP-9, one of the crucial mediators of SOS development. …
• NAID 120005530955

• 関節リウマチ患者に対する人工膝関節置換術の効果の分析 : 局所的効果,全身的疾患活動性,生活の質への影響の比較

• 岡田 貴士,平野 裕司,竹本 元大 [他]
• 日本関節病学会誌 34(1), 45-50, 2015
• NAID 40020427830

---

★リンクテーブル★

リンク元	「マトリックスメタロプロテアーゼ1」「MMP-1」「interstitial collagenase」
拡張検索	「matrix metalloproteinase 10」「matrix metalloproteinase 12」「matrix metalloproteinase 13」「matrix metalloproteinase 14」「matrix metalloproteinase 17」
関連記事	「matrix metalloproteinase」「metalloproteinase」「metalloproteinases」

「マトリックスメタロプロテアーゼ1」

　　[★]

英

matrix metalloproteinase 1、MMP-1

関

マトリックスメタロプロテイナーゼ1

「MMP-1」

　　[★]

• マトリックスメタロプロテアーゼ1

関

matrix metalloproteinase 1

「interstitial collagenase」

　　[★]

• 間質コラゲナーゼ

関

matrix metalloproteinase 1

「matrix metalloproteinase 10」

　　[★]

マトリックスメタロプロテアーゼ10

関

MMP-10

「matrix metalloproteinase 12」

　　[★]

マトリックスメタロプロテアーゼ12

関

MMP-12

「matrix metalloproteinase 13」

　　[★]

マトリックスメタロプロテアーゼ13

関

MMP-13

「matrix metalloproteinase 14」

　　[★]

マトリックスメタロプロテアーゼ14

関

MMP-14

「matrix metalloproteinase 17」

　　[★]

マトリックスメタロプロテアーゼ17

関

MMP-17

「matrix metalloproteinase」

　　[★] マトリックスメタロプロテアーゼ MMP

「metalloproteinase」

　　[★] メタロプロテアーゼ

「metalloproteinases」

　　[★] メタロプロテアーゼ