- 関
- matrix metalloproteinase 1
WordNet
- of or relating to interstices
- any enzyme that catalyzes the hydrolysis of collagen and gelatin
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/06 16:56:51」(JST)
[Wiki en表示]
| Interstitial collagenase |
| Identifiers |
| EC number |
3.4.24.7 |
| CAS number |
2593923 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
Interstitial collagenase (EC 3.4.24.7, vertebrate collagenase, matrix metalloproteinase 1) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile in the alpha1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue
This enzyme belongs to the peptidase family M10.
See also
References
- ^ Goldberg, G.I., Wilhelm, S.M., Kronberger, A., Bauer, E.A., Grant, G.A. and Eisen, A.Z. (1986). "Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein". J. Biol. Chem. 261: 6600–6605. PMID 3009463.
- ^ Birkedal-Hansen, H. (1987). "Catabolism and turnover of collagens: collagenases". Methods Enzymol. 144: 140–171. doi:10.1016/0076-6879(87)44177-3. PMID 3041177.
- ^ Fields, G.B., Van Wart, H.E. and Birkedal-Hansen, H. (1987). "Sequence specificity of human skin fibroblast collagenase. Evidence for the role of collagen structure in determining the collagenase cleavage site". J. Biol. Chem. 262: 6221–6226. PMID 3032960.
- ^ Sottrup-Jensen, L. and Birkedal-Hansen, H. (1989). "Human fibroblast collagenase-α-macroglobulin interactions. Localization of cleavage sites in the bait regions of five mammalian α-macroglobulins". J. Biol. Chem. 264: 393–401. PMID 2462561.
External links
- Interstitial collagenase at the US National Library of Medicine Medical Subject Headings (MeSH)
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Wnt-3a-activated human fibroblasts promote human keratinocyte proliferation and matrix destruction.
- Sobel K1, Tham M, Stark HJ, Stammer H, Prätzel-Wunder S, Bickenbach JR, Boukamp P.
- International journal of cancer. Journal international du cancer.Int J Cancer.2015 Jun 15;136(12):2786-98. doi: 10.1002/ijc.29336. Epub 2014 Nov 26.
- Aberrant Wnt regulation, detectable by nuclear translocation of beta-catenin, is a hallmark of many cancers including skin squamous cell carcinomas (SCCs). By analyzing primary human skin SCCs, we demonstrate that nuclear beta-catenin is not restricted to SCC cells but also detected in stromal fibro
- PMID 25403422
- The skin remodeling in type 1 diabetes and insulin resistance animal models.
- Knaś M1, Wołosik K, Zalewska A, Mikucka-Niczyporuk A, Kasacka I, Niczyporuk M.
- Physiological research / Academia Scientiarum Bohemoslovaca.Physiol Res.2015 Jun 5. [Epub ahead of print]
- The skin matrix metalloproteinase 3, tissue inhibitors of matrix metalloproteinase 2 and collagen III content changes in type 1 diabetes and insulin resistance treated with insulin and metformin were studied. Healthy adult male Wistar rats were obtained from experimental animal house, Department of
- PMID 26047379
- Preferential Sites for Intramolecular Glucosepane Cross-link Formation in Type I Collagen: A Thermodynamic Study.
- Collier TA1, Nash A2, Birch HL3, de Leeuw NH2.
- Matrix biology : journal of the International Society for Matrix Biology.Matrix Biol.2015 Jun 3. pii: S0945-053X(15)00119-5. doi: 10.1016/j.matbio.2015.06.001. [Epub ahead of print]
- The extracellular matrix (ECM) undergoes progressive age-related stiffening and loss of proteolytic digestibility due to an increase in concentration of advanced glycation end products (AGEs). The most abundant AGE, glucosepane, accumulates in collagen with concentrations over 100 times greater than
- PMID 26049074
Japanese Journal
- Role of Endothelial Nitric Oxide Synthase and Collagen Metabolism in Right Ventricular Remodeling due to Pulmonary Hypertension
- 微細構造を考慮した力学モデルに基づく軟骨の変性評価
- Whole body hyperthermia による間質コラゲナーゼ活性の変化と問質リモデリング仮説
- 日本ハイパーサーミア学会誌 = Japanese journal of hyperthermic oncology 26(4), 109-119, 2010-12-20
- NAID 10027645996
★リンクテーブル★
[★]
マトリックスメタロプロテアーゼ1、マトリックスメタロプロテイナーゼ1
- 関
- interstitial collagenase、MMP-1
[★]
- 英
- interstitial collagenase
- 関
- マトリックスメタロプロテイナーゼ1
[★]
- 間質性の、間質内の、侵入型の、組織内の、介在の、介在性の、中間部の、間質の
- 関
- intercalary、intermediate、internuncial、interstitial tissue、interstitium、intervene、intervening、interzonal、invasive、stroma、stromal、stromata