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1. 変形性関節症の初回薬物療法 initial pharmacologic therapy of osteoarthritis
2. 男性型多毛症の治療 treatment of hirsutism
3. 小児および思春期における咽頭痛：対症療法 sore throat in children and adolescents symptomatic treatment
4. 思春期における多嚢胞性卵巣症候群の治療 treatment of polycystic ovary syndrome in adolescents
5. 女性における慢性骨盤痛の治療 treatment of chronic pelvic pain in women

Takahashi S1, Katoh M, Saitoh T, Nakajima M, Yokoi T.
Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2009 May;37(5):956-61. doi: 10.1124/dmd.108.024331. Epub 2009 Feb 18.
In vitro inhibition studies on drug-metabolizing enzyme activity are useful for understanding drug-drug interactions and for drug development. However, the profile of the inhibitory effects of carboxylesterase (CES) activity has not been fully investigated concerning species and tissue differences.
PMID 19225040

[Evaluation of efficacy and safety of manidipine hydrochloride among essential hypertensive patients: Substitution from branded product (Calslot) to Generic Product (Manidip)].

Kobayashi H1, Obara T, Takahashi N, Takahashi T, Igari Y, Oikawa T, Saito S, Ohkubo T, Imai Y, Takahashi M.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.Yakugaku Zasshi.2007 Dec;127(12):2045-50.
Calcium channel blockers are most commonly used in hypertensive patients in Japan. However, information on the efficacy and safety of generic calcium channel blockers is insufficient. The objective of the present study was to retrospectively evaluate the efficacy and safety of manidipine hydrochlori
PMID 18057792

Effects of compression on the interaction between 1,4-dihydropyridine compounds and lactose monohydrate (II): differences in powder properties of 1,4-dihydropyridine compounds.

Hosaka S1, Sadoshima T, Sato M, Hamada C, Takahashi Y, Kitamori N.
Chemical & pharmaceutical bulletin.Chem Pharm Bull (Tokyo).2007 May;55(5):793-5.
The solid-state interaction between manidipine dihydrochloride (Man) or benidipine hydrochloride (Ben) and lactose monohydrate (Lac) was investigated. An endothermic peak area at 170 degrees C was observed when their mixtures were subjected to differential scanning calorimetry (DSC) measurement, and
PMID 17473471

Effects of Compression on the Interaction between 1,4-Dihydropyridine Compounds and Lactose Monohydrate (II): Differences in Powder Properties of 1,4-Dihydropyridine Compounds