マクロゴール
WordNet
- tropical marine gastropods having beautifully colored spiral shells
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/05 01:55:26」(JST)
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Macrogol
|
Systematic (IUPAC) name |
Not available
|
Clinical data |
AHFS/Drugs.com |
International Drug Names |
MedlinePlus |
a603032 |
Identifiers |
CAS Registry Number |
25322-68-3 Y |
ATC code |
A06AD15 |
UNII |
3WJQ0SDW1A Y |
Chemical data |
Formula |
H-(OCH2CH2)n-OH |
Molecular mass |
Not available |
N (what is this?) (verify) |
Macrogol is the International Nonproprietary Name (INN) for polyethylene glycol. Macrogols have been used as laxatives, i.e. to treat constipation.[1]
They are also used as excipients in pharmaceutical products where lower molecular weight variants are used as solvents in oral liquids and soft capsules. Solid variants are used as ointment bases, tablet bindings, film coatings and lubricants.[2]
Popular types include:
- macrogol 3350[3]
- macrogol 4000[4]
- macrogol 6000[5]
The number represents the average molecular weight of the polyethylene glycol. Combining different molecular weights provides some control over the consistency.[2]
Available forms
Macrogol (polyethylene glycol) is sold as non-prescription preparation in powder form under trade names SoftLax, Purelax, Miralax, Glycoprep, Movicol, Macrogol (generic), Cololyt and Osmolax, among others. It is dissolved in a glass of water to create a clear, tasteless and odorless solution and is swallowed.
References
- ^ Zangaglia R, Martignoni E, Glorioso M et al. (2007). "Macrogol for the treatment of constipation in Parkinson's disease. A randomized placebo-controlled study". Mov. Disord. 22 (9): 1239–44. doi:10.1002/mds.21243. PMID 17566120.
- ^ a b Smolinske, Susan C. (1992). Handbook of Food, Drug, and Cosmetic Excipients. p. 287. ISBN 9780849335853.
- ^ Hardikar W, Cranswick N, Heine RG (2007). "Macrogol 3350 plus electrolytes for chronic constipation in children: a single-centre, open-label study". Journal of Paediatrics and Child Health 43 (7–8): 527–31. doi:10.1111/j.1440-1754.2007.01116.x. PMID 17635680.
- ^ "CID 27175 -- PubChem Compound Summary". Retrieved 2008-01-18.
- ^ Hyry H, Vuorio A, Varjonen E, Skyttä J, Mäkinen-Kiljunen S (2006). "Two cases of anaphylaxis to macrogol 6000 after ingestion of drug tablets". Allergy 61 (8): 1021. doi:10.1111/j.1398-9995.2006.01083.x. PMID 16867059.
Drugs for constipation (laxatives and cathartics) (A06)
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Softeners, emollients |
- Liquid paraffin
- Docusate sodium
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Contact laxatives |
- Oxyphenisatine
- Bisacodyl
- Dantron
- Phenolphthalein
- Castor oil
- Senna glycosides
- Cascara
- Sodium picosulfate
- Bisoxatin
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Bulk-forming laxatives |
- Ispaghula
- Ethulose
- Sterculia
- Linseed
- Methylcellulose
- Triticum
- Polycarbophil calcium
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Osmotically acting laxatives |
- Magnesium carbonate
- Magnesium hydroxide
- Magnesium oxide
- Magnesium peroxide
- Magnesium sulfate
- Lactulose
- Lactitol
- Sodium sulfate
- Pentaerythritol
- Macrogol
- Mannitol
- Sodium phosphate
- Sorbitol
- Magnesium citrate
- Sodium tartrate
- Laminarid
- Polyethylene glycol;
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|
Enemas |
- Sodium laurilsulfate
- Sodium phosphate
- Bisacodyl
- Dantron
- Glycerol
- Oil
- Sorbitol
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|
Peripheral opioid antagonists |
- Alvimopan
- Methylnaltrexone
- Naloxegol
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Prostaglandins |
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Other |
- Linaclotide
- Prucalopride
- Tegaserod
- Ulimorelin
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Index of digestion
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Description |
- Anatomy
- Physiology
- Development
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|
Disease |
- Congenital
- Neoplasms and cancer
- Inflammatory bowel disease
- Gluten sensitivity
- Other
- Symptoms and signs
- Blood tests
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Treatment |
- Procedures
- Drugs
- anabolic steroids
- antacids
- diarrhoea and infection
- bile and liver
- functional gastrointestinal disorders
- laxatives
- peptic ulcer and reflux
- nausea and vomiting
- other
- Surgery
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UpToDate Contents
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English Journal
- Size distribution of microbubbles as a function of shell composition.
- Dicker S, Mleczko M, Schmitz G, Wrenn SP.SourceDepartment of Chemical Engineering, Drexel University, Philadelphia, PA 19104, USA. smd82@drexel.edu
- Ultrasonics.Ultrasonics.2013 Sep;53(7):1363-7. doi: 10.1016/j.ultras.2013.04.004. Epub 2013 Apr 12.
- The effect of modifying the shell composition of a population of microbubbles on their size demonstrated through experiment. Specifically, these variations include altering both the mole fraction and molecular weight of functionalized polymer, polyethylene glycol (PEG) in the microbubble phospholipi
- PMID 23642496
- Polyethylene Glycol as an alternative polymer solvent for Nanoparticle Preparation.
- Ali ME, Lamprecht A.SourceLaboratory of Pharmaceutical Technology and Biopharmaceutics, Institute of Pharmacy, University of Bonn, Bonn, Germany; Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
- International journal of pharmaceutics.Int J Pharm.2013 Aug 16. pii: S0378-5173(13)00724-2. doi: 10.1016/j.ijpharm.2013.07.077. [Epub ahead of print]
- Solvent toxicity is one of the major drawbacks in the preparation of polymeric nanoparticles today. Here, polyethylene glycols (PEG) are proposed as non-toxic solvents for the preparation of polymeric nanoparticles. Based on a preparation process similar to the solvent displacement technique, severa
- PMID 23958752
- (pGlu-Gln)-CCK-8[mPEG]: a novel, long-acting, mini-PEGylated cholecystokinin (CCK) agonist that improves metabolic status in dietary-induced diabetes.
- Irwin N, Frizelle P, O'Harte FP, Flatt PR.SourceSchool of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, UK. n.irwin@ulster.ac.uk
- Biochimica et biophysica acta.Biochim Biophys Acta.2013 Aug;1830(8):4009-16. doi: 10.1016/j.bbagen.2013.04.004. Epub 2013 Apr 10.
- BACKGROUND: Cholecystokinin (CCK) is a gastrointestinal hormone that has been proposed as a potential therapeutic option for obesity-diabetes. As such, (pGlu-Gln)-CCK-8 is an N-terminally modified CCK-8 analogue with improved biological effectiveness over the native peptide.METHODS: The current stud
- PMID 23583730
Japanese Journal
- 軟膏剤の調剤における基剤の選択に関する検討 : フィプロニルを有効成分とする滴下投与用液剤を原薬のモデルとして
- AJG522の日本人健康成人における安全性および大腸内視鏡検査前処置に対する有効性の検討
- 臨床薬理 = Japanese journal of clinical pharmacology 44(2), 53-60, 2013-03-31
- NAID 10031165664
- 経口腸管洗浄剤ニフレック®によるアナフィラキシーの1例
Related Links
- マクロゴールは、日本薬局方(局方)または医薬品添加物規格(薬添規)に収載された規格を満たすポリエチレングリコール(Polyethylene glycol)であって、下記の一般式で表されます。 HOCH 2 (CH 2 OCH 2 )nCH ...
- マクロゴールの両末端は第1級アルコールですので、エステル化やエーテル化が容易です。 ・ マクロゴールの水に対する溶解性は電解質の存在によって影響されません。硬水や塩類の水溶性はもちろん、酸やアルカリ(ただし極端に高濃度の ...
Related Pictures
★リンクテーブル★
[★]
- 英
- polyethylene glycol、polyethyleneglycol、PEG
- 同
- マクロゴール macrogol
- 商
- Colovate, Colyte, GoLYTELY
- (免疫グロブリンの処理)テタノブリン、ヘブスブリン、グロベニン、ヴェノグロブリン
- (経口腸管洗浄剤)ムーベン、ニフプラス、ニフレック
- (軟膏)ウレパール、フルコート、マクロゴール
- 関
- トリトン、ポリオキシエチレン
[★]
- 英
- macrogol
- ラ
- macrogolum
- 関
- トリトン triton、ポリエチレングリコール polyethylene glycol PEG、ポリオキシエチレン polyoxyethylene
- マクロゴール6000、マクロゴール4000、マクロゴール400
[★]
トリトン
- 関
- macrogol、Neptune、polyethylene glycol、polyoxyethylene
[★]
ポリオキシエチレン
- 関
- macrogol、polyethylene glycol、triton
[★]
- 英
- macrogol
- 関
- マクロゴール
[★]
ラウロマクロゴール
[★]
ラウロマクロゴール