WordNet

a complex consisting of an organic base in association with hydrogen chloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/08/18 10:34:44」(JST)

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Lomefloxacin hydrochloride (sold under the following brand names in English speaking countries Maxaquin, Okacyn, Uniquin) is a fluoroquinolone antibiotic used to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery. Lomefloxacin is associated with phototoxicity and central nervous system adverse effects.^[1]

October 2008 the FDA added the following black box warning to the product insert for Maxaquin: Lomefloxacin is unique in that it forms a magnesium chelate with itself. The chelate is formed between the 2-carbonyl group of two separate lomefloxacin molecules.

References

^ Rubinstein, E. (2001). "History of quinolones and their side effects.". Chemotherapy. 47 (Suppl 3): 3–8; discussion 44–8. PMID 11549783. doi:10.1159/000057838.

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English Journal

Removal of five fluoroquinolone antibiotics during broiler manure composting.

Yang B1, Meng L1, Xue N1.
Environmental technology.Environ Technol.2018 Feb;39(3):373-381. doi: 10.1080/09593330.2017.1301568. Epub 2017 Mar 16.
PMID 28278096

Occurrence of antibiotics in mussels and clams from various FAO areas.

Chiesa LM1, Nobile M1, Malandra R2, Panseri S3, Arioli F1.
Food chemistry.Food Chem.2018 Feb 1;240:16-23. doi: 10.1016/j.foodchem.2017.07.072. Epub 2017 Jul 17.
PMID 28946257

Enhancement of lomefloxacin Hcl ocular efficacy via niosomal encapsulation: in vitro characterization and in vivo evaluation.

Khalil RM1, Abdelbary GA2, Basha M1, Awad GEA3, El-Hashemy HA1.
Journal of liposome research.J Liposome Res.2017 Dec;27(4):312-323. doi: 10.1080/08982104.2016.1191022. Epub 2016 Jun 30.
PMID 27241274

Japanese Journal

Enantioseparation of lomefloxacin hydrochloride by high-speed counter-current chromatography using sulfated-β-cyclodextrin as a chiral selector

WEI Yun,DU Shijuan,ITO Yoichiro
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 878(28), 2937-2941, 2010-10-15
NAID 10028043142

Validated Polarographic Methods for the Determination of Certain Antibacterial Drugs

, ,
Analytical Sciences 23(9), 1053-1058, 2007
… Two simple, precise, inexpensive and sensitive voltammetric methods for the determination of lomefloxacin (LFX), sparfloxacin hydrochloride (SFX), gatifloxacin (GFX), and moxifloxacin (MFX) were developed. …
NAID 130004441530

Electrochemical Adsorptive Behavior of Some Fluoroquinolones at Carbon Paste Electrode

, , [他],
Analytical Sciences 21(10), 1249-1254, 2005
… A simple, precise, inexpensive and sensitive voltammetric method has been developed for the determination of the cited drugs (Lomefloxacin (LFX), Sparfloxacin hydrochloride (SFX), and Gatifloxacin (GFX)). …
NAID 130004826361

「ロメフロキサシン」

Lomefloxacin
Clinical data
Trade names	Maxaquin
AHFS/Drugs.com	Consumer Drug Information
MedlinePlus	a600002
ATC code	J01MA07 (WHO) S01AE04 (WHO);
Pharmacokinetic data
Protein binding	10%
Biological half-life	8 hours
Identifiers
	IUPAC name (RS)-1-Ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic acid;
CAS Number	98079-51-7 ;
PubChem CID	3948;
DrugBank	DB00978 ;
ChemSpider	3811 ;
UNII	9VC7S3ZXXB;
KEGG	D02318 ;
ChEBI	CHEBI:116278 ;
ChEMBL	CHEMBL561 ;
ECHA InfoCard	100.117.399
Chemical and physical data
Formula	C17H19F2N3O3
Molar mass	351.348 g/mol
3D model (JSmol)	Interactive image;
	SMILES Fc1c(c(F)c2c(c1)C(=O)C(\C(=O)O)=C/N2CC)N3CC(NCC3)C ;
	InChI InChI=1S/C17H19F2N3O3/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25) ; Key:ZEKZLJVOYLTDKK-UHFFFAOYSA-N ;
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