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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/02 01:20:05」(JST)

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Lomefloxacin hydrochloride (sold under the following brand names in English speaking countries Maxaquin, Okacyn, Uniquin) is a fluoroquinolone antibiotic used to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery. Lomefloxacin is associated with phototoxicity and central nervous system adverse effects.^[1]

October 2008 the FDA added the following black box warning to the product insert for Maxaquin: Lomefloxacin is unique in that it forms a magnesium chelate with itself. The chelate is formed between the 2-carbonyl group of two separate lomefloxacin molecules.

References

^ Rubinstein, E. (2001). "History of quinolones and their side effects.". Chemotherapy 47 (Suppl 3): 3–8; discussion 44–8. doi:10.1159/000057838. PMID 11549783.

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1. フルオロキノロン類 fluoroquinolones

English Journal

Interaction between holo transferrin and HSA-PPIX complex in the presence of lomefloxacin: An evaluation of PPIX aggregation in protein-protein interactions.

Sattar Z, Iranfar H, Asoodeh A, Saberi MR, Mazhari M, Chamani J.SourceDepartment of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2012 Nov;97:1089-100. doi: 10.1016/j.saa.2012.07.034. Epub 2012 Aug 4.
Human serum albumin (HSA) and holo transferrin (TF) are two serum carrier proteins that are able to interact with each other, thereby altering their binding behavior toward their ligands. During the course of this study, the interaction between HSA-PPIX and TF, in the presence and absence of lomeflo
PMID 22925987

Determination of eight fluoroquinolones in groundwater samples with ultrasound-assisted ionic liquid dispersive liquid-liquid microextraction prior to high-performance liquid chromatography and fluorescence detection.

Vázquez MM, Vázquez PP, Galera MM, García MD.SourceDepartment of Analytical Chemistry, University of Almería, La Cañada de San Urbano, 04120 Almería, Spain.
Analytica chimica acta.Anal Chim Acta.2012 Oct 20;748:20-7. doi: 10.1016/j.aca.2012.08.042. Epub 2012 Aug 30.
An ultrasound-assisted ionic liquid dispersive liquid-liquid microextraction (US-IL-DLLME) procedure was developed for the extraction of eight fluoroquinolones (marbofloxacin, norfloxacin, ciprofloxacin, lomefloxacin, danofloxacin, enrofloxacin, oxolinic acid and nalidixic acid) in groundwater, usin
PMID 23021803

Japanese Journal

Efficacy and safety of lomefloxacin on bacterial extraocular disease in the horse

, , ,
Journal of Veterinary Medical Science advpub(0), 2015
… Lomefloxacin is a broad-spectrum fluoroquinolone antibiotic used for the treatment of bacterial extraocular disease. … This study investigated the efficacy and safety of lomefloxacin eye drops for bacterial extraocular disease in horses. … Lomefloxacin ophthalmic solution (0.3%) was instilled three times daily for 2–5 days in 65 horses diagnosed with bacterial extraocular disease based on clinical findings. … The efficacy of lomefloxacin was evaluated in 63 horses; …
NAID 130004781129

犬の細菌性外耳炎に対する0.3%ロメフロキサシン眼科耳科用液の治療効果

高島一昭,仲庭茂樹,山根義久
動物臨床医学 = Journal of Animal Clinical Research Foundation 22(3), 096-100, 2013-09-20
NAID 10031201070

特集新効能動物用抗菌性物質製剤ロメフロキサシン(効能追加)

守先眞由美,末信敏秀,坂本祐一郎 [他]
動物用抗菌剤研究会報 (34), 40-47, 2012-11
NAID 40019558031

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★リンクテーブル★

リンク元	「ロメフロキサシン」
拡張検索	「lomefloxacin hydrochloride」

「ロメフロキサシン」

Lomefloxacin
Systematic (IUPAC) name
	(RS)-1-Ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic acid
Clinical data
Trade names	Maxaquin
AHFS/Drugs.com	Consumer Drug Information
MedlinePlus	a600002
Pharmacokinetic data
Protein binding	10%
Biological half-life	8 hours
Identifiers
CAS Number	98079-51-7
ATC code	J01MA07 (WHO) S01AE04 (WHO)
PubChem	CID 3948
DrugBank	DB00978
ChemSpider	3811
UNII	9VC7S3ZXXB
KEGG	D02318
ChEBI	CHEBI:116278
ChEMBL	CHEMBL561
Chemical data
Formula	C17H19F2N3O3
Molar mass	351.348 g/mol
	SMILES Fc1c(c(F)c2c(c1)C(=O)C(\C(=O)O)=C/N2CC)N3CC(NCC3)C ;
	InChI InChI=1S/C17H19F2N3O3/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25) ; Key:ZEKZLJVOYLTDKK-UHFFFAOYSA-N ;
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