WordNet

of or relating to or situated in the larynx; "laryngeal infection"
a benign epithelial tumor forming a rounded mass (同)villoma, papillary_tumor, papillary tumour

PrepTutorEJDIC

喉頭(こうとう)の;(音声が)喉頭音の

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/15 11:04:23」(JST)

wiki en

Laryngeal papillomatosis, also known as recurrent respiratory papillomatosis or glottal papillomatosis, is a rare medical condition (2 per 100,000 adults and 4.5 per 100,000 children)^[1]^:411, caused by a HPV infection of the throat.^[2]^:411 Laryngeal papillomatosis causes assorted tumors or papillomas to develop over a period. Without treatment it is potentially fatal as uncontrolled growths could obstruct the airway. Laryngeal papillomatosis is caused by HPV types 6 and 11, in which benign tumors form on the larynx or other areas of the respiratory tract. These tumors can recur frequently, may require repetitive surgery, and may interfere with breathing. The disease can be treated with surgery and antivirals.

Transmission [edit]

In general, doctors are not sure what causes some people to contract laryngeal papillomatosis while others who have been exposed to HPV types 6 and 11 do not contract the disease. Since the disease is most commonly found in children the disease may be caused by an infant contracting HPV from the mother during vaginal child birth ^[3]^:411. There is no evidence that it is transmitted through oral sex, and it is not considered a sexually transmitted disease.^[4]

Symptoms [edit]

Adults [edit]

In adults the symptoms Laryngeal papillomatosis are hoarseness, or a strained or breathy voice. Size and placement of the tumors dictate the change in the person's voice. Breathing difficulties may occur but more commonly are found in children.^[3]

Children [edit]

In babies and small children the symptoms include a weak cry, trouble swallowing, noisy breathing, and chronic cough. Noisy breathing may be a stridor, which can sound like a whistle or a snore, and is a sign that the laryngeal or tracheal parts of the airway are narrowing.^[3]

Diagnosis [edit]

A doctor may diagnose laryngeal papillomatosis by placing a mirror into a patient's mouth to reflect light onto the vocal cords and examining the larynx. More often, a doctor or a trained speech-language pathologist diagnoses laryngeal papillomatosis by an indirect laryngoscopy in the office. This procedure involves the placement of a flexible, fiber optic camera through the patient's nose to view the vocal folds in the throat or the use of a straight, rigid camera placed through the mouth to view the vocal folds.^[5]

The most accurate way to diagnose laryngeal papillomatosis is for a biopsy to be conducted and for the lesion to be tested for HPV. This procedure takes place in an operating room with the patient under general anesthesia. This is sometimes the best option for small children. This disease is most often misdiagnosed as asthma, croup, or chronic bronchitis.^[4] The consequences may be serious, as papillomas are at least partially obstructing the airway to cause these symptoms and should be removed immediately.^[5]

Treatment [edit]

Traditional surgery and carbon dioxide laser surgery, a "no touch" removal of affected tissue, are forms of treatment for laryngeal papillomatosis. Carbon dioxide laser removal is the most common removal method.^[4] The carbon dioxide laser must be used precisely to prevent scarring, fibrosis, and laryngeal web malformation. In children, carbon dioxide laser is effective for removing papillomas on the larynx. Photodynamic therapy controls tumors by using targeted dyes and bright light to illuminate tumors.^[1] In this procedure, a doctor injects a light sensitive dye that is only absorbed by the tumors. Then the doctor activates the dye using a bright light, and the tumors are eliminated. This procedure has also been able to decrease the number of tumors that reoccur.^[1] Another method is tracheotomy, which reroutes air around the affected area. An incision is made in the front of the patient's neck, and a breathing tube is inserted through a hole (stoma) into the windpipe. The patient is then able to breathe through the tube. Although this is usually temporary, some patients must use the tube indefinitely.^[1] This method should be avoided if at all possible, since insertion of a breathing tube may cause the tumors to form as far down as the lungs.^[4] Many Antiviral drugs like Cidofovir have been used to treat laryngeal papillomatosis, but none completely stops the tumors from growing. Most antivirals are injected to control the frequency of tumor growth. The efficacy of the same is debated and subject to research. Some side effects of antivirals include dizziness, headaches, and body aches. Regardless of the treatment used, the tumors will reoccur. In severe cases, tumors may occur once or twice a month. In less severe cases, tumors may occur once or twice a year.

References [edit]

^ ^a ^b ^c ^d ">"National Institute of Deafness and other Communication Disorders". http://www.nidcd.nih.gov/health/voice/laryngeal.asp. Missing or empty |url= (help); |accessdate= requires |url= (help)
^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
^ ^a ^b ^c ">"VoiceProblems.org". http://www.voiceproblem.org/disorders/rrp/symptoms.asp. Missing or empty |url= (help); |accessdate= requires |url= (help)
^ ^a ^b ^c ^d ">McClay MD,John E (10/29/08). "Recurrent Respiratory Papillomatosis". http://www.voiceproblem.org/disorders/rrp/symptoms.asp. Missing or empty |url= (help); |accessdate= requires |url= (help)
^ ^a ^b ">"Recurrent Respiraory Papillomatosis Foundation". http://www.nidcd.nih.gov/health/voice/laryngeal.asp. Missing or empty |url= (help); |accessdate= requires |url= (help)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 小児における嗄声：病因およびマネージメント hoarseness in children etiology and management
2. 成人における嗄声 hoarseness in adults
3. 頭頚部癌に関連するヒトパピローマウイルス human papillomavirus associated head and neck cancer
4. Techniques and devices for airway management for anesthesia: Supraglottic devices (including laryngeal mask airways)
5. 頸動脈内膜剥離術および頸動脈ステント留置術の麻酔 anesthesia for carotid endarterectomy and carotid stenting

English Journal

Adult Recurrent Respirator Papillomatosis: A New Therapeutic Approach with Pegylated Interferon Alpha 2a (Peg-IFNα-2a) and GM-CSF.

Suter-Montano T, Montaño E, Martínez C, Plascencia T, Sepulveda MT, Rodríguez M.SourceMedical Practice of Dr R. Engler ENT (Buchs SG), Daenikon-Zürich, Switzerland.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.Otolaryngol Head Neck Surg.2013 Feb;148(2):253-60. doi: 10.1177/0194599812466226. Epub 2012 Nov 2.
Objective To determine a new therapeutic approach using granulocyte monocyte-colony-stimulating factor (GM-CSF) and pegylated interferon alpha 2a (Peg-IFNα-2a) as adjuvant therapy in patients with adult recurrent respiratory papillomatosis. Study Design Descriptive observational clinical trial. S
PMID 23124924

Experience with recurrent respiratory papillomatosis in a developing country: impact of tracheostomy.

Orji FT, Okorafor IA, Akpeh JO.SourceDepartment of Otolaryngology, University of Nigeria Teaching Hospital, Enugu, Nigeria, tochiorji@yahoo.com.
World journal of surgery.World J Surg.2013 Feb;37(2):339-43. doi: 10.1007/s00268-012-1839-y.
BACKGROUND: The frequent relapses of recurrent respiratory papillomatosis (RRP) sometimes demand repeated surgical excision with tracheostomy. This situation plays a vital role in the management of RRP in developing countries such as ours because of late presentation. This study was conducted to eva
PMID 23135424