WordNet

with the wind abaft the beam; "a ship sailing large"
a garment size for a large person
above average in size or number or quantity or magnitude or extent; "a large city"; "set out for the big city"; "a large sum"; "a big (or large) barn"; "a large family"; "big businesses"; "a big expenditure"; "a large number of newspapers"; "a big group of scientists"; "large areas of the world" (同)big
at a distance, wide of something (as of a mark)
fairly large or important in effect; influential; "played a large role in the negotiations"
having broad power and range and scope; "taking the large view"; "a large effect"; "a large sympathy"
an agranulocytic leukocyte that normally makes up a quarter of the white blood cell count but increases in the presence of infection (同)lymph cell

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Steinway SN1, LeBlanc F1, Loughran TP Jr2.
Blood reviews.Blood Rev.2014 May;28(3):87-94. doi: 10.1016/j.blre.2014.02.001. Epub 2014 Mar 7.
Large granular lymphocyte (LGL) leukemia is a spectrum of rare lymphoproliferative diseases of T lymphocytes and natural killer cells. These diseases frequently present with splenomegaly, neutropenia, and autoimmune diseases like rheumatoid arthritis. LGL leukemia is more commonly of a chronic, indo
PMID 24679833

Mishra A1, Sullivan L, Caligiuri MA.
Clinical cancer research : an official journal of the American Association for Cancer Research.Clin Cancer Res.2014 Apr 15;20(8):2044-50. doi: 10.1158/1078-0432.CCR-12-3603.
Interleukin-15 (IL-15) is a proinflammatory cytokine involved in the development, survival, proliferation, and activation of multiple lymphocyte lineages utilizing a variety of signaling pathways. IL-15 utilizes three distinct receptor chains in at least two different combinations to signal and exer
PMID 24737791

Abnormalities of quantities and functions of natural killer cells in severe aplastic anemia.

Liu C1, Li Z, Sheng W, Fu R, Li L, Zhang T, Wu Y, Xing L, Song J, Wang H, Shao Z.
Immunological investigations.Immunol Invest.2014 Mar 24. [Epub ahead of print]
Severe aplastic anemia (SAA) is a rare disease characterized by severe pancytopenia and bone marrow failure. Natural killer (NK) cells are large granular lymphocytes derived from hematopoietic stem cells (HSCs) or common lymphoid progenitors (CLP). They play a key role in n the innate immunity and a
PMID 24661133

石田文宏
臨床血液 56(6), 645-650, 2015
アグレッシブNK細胞白血病(ANKL)は成熟NK細胞の白血病で，生存期間中央値が3か月以内と予後不良である。東アジアに多く，8割以上がEBウイルスと関連する。最近実施した34例のANKL07研究では年齢中央値40歳で2相性分布を示した。ANKLの細胞はLGL様から高度異型まで多彩であり，また，三分の一の例では末梢血・骨髄の腫瘍細胞が20%未満であり，診断に留意する必要がある。臨床所見として発熱，肝 …
NAID 130005093098

藤原英世,薄聖子,近藤敏範,関口和,石田文宏,岡大五,是澤里紗,和田秀穂,杉原尚,定平吉都
川崎医学会誌 41(1), 19-26, 2015
… T-cell large granular lymphocyte leukemia は長期(6か月以上)にわたる末梢血中の著明な大顆粒リンパ球(large granular lymphocyte;以下,LGL)のモノクローナルな増加によって特徴づけられる疾患で,しばしば赤芽球癆を伴うことが知られている.今回,我々はHCV陽性肝硬変患者に赤芽球癆を合併したT-LGLの1例を経験した.末梢血および骨髄塗抹標本では細胞質内に微細なアズール顆粒を …
NAID 110009924805

松尾梢恵,熊坂利夫,中昂一,阿部直也,橋本昭一,藤原睦憲,武村民子
日本臨床細胞学会雑誌 52(5), 454-458, 2013-09-22
背景 : Myeloid sarcoma (MS) は, 骨髄芽球や未分化な骨髄系細胞が髄外に腫瘤を形成する疾患と定義される. 今回われわれは, 非白血病患者の縦隔および骨盤腔内に腫瘤を形成し, 胸水・心嚢水の貯留が認められ, 胸水細胞診で診断しえた MS の 1 例を報告する.症例 : 32 歳, 女性. 発熱, 咳, 胸痛を主訴に受診. 縦隔および骨盤腔内の腫瘤と左胸水・心嚢水貯留を認めた. …
NAID 10031191691