WordNet

with the wind abaft the beam; "a ship sailing large"
a garment size for a large person
above average in size or number or quantity or magnitude or extent; "a large city"; "set out for the big city"; "a large sum"; "a big (or large) barn"; "a large family"; "big businesses"; "a big expenditure"; "a large number of newspapers"; "a big group of scientists"; "large areas of the world" (同)big
at a distance, wide of something (as of a mark)
fairly large or important in effect; influential; "played a large role in the negotiations"
having broad power and range and scope; "taking the large view"; "a large effect"; "a large sympathy"
small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
any malignant tumor derived from epithelial tissue; one of the four major types of cancer
of or relating to the nervous and endocrine systems (especially as they function together)

PrepTutorEJDIC

(同じ種類のものと比較して,形・体積・数量などが)『大きい』,多い,広い / (考えなどが)広範囲な,幅の広い,寛大な / 大きく / 自慢して,誇大に
(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
がん,がん腫

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/03/30 16:14:51」(JST)

wiki en

Large cell neuroendocrine carcinoma of the lung (LCNEC) is a highly malignant neoplasm arising from transformed epithelial cells originating in tissues within the pulmonary tree. It is currently considered to be a subtype of large cell lung carcinoma.

LCNEC is often generically grouped among the non-small cell lung carcinomas.^[1]

Variants

The World Health Organization classification of lung tumors^[1] recognizes a variant of LCNEC, namely "combined large cell neuroendocrine carcinoma" (c-LCNEC).

References

^ ^a ^b Travis, William D; Brambilla, Elisabeth; Muller-Hermelink, H Konrad et al., eds. (2004). Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. World Health Organization Classification of Tumours. Lyon: IARC Press. ISBN 92-832-2418-3. Retrieved 27 March 2010. |displayeditors= suggested (help)

External links

Lung Cancer Home Page. The National Cancer Institute site containing further reading and resources about lung cancer.
[1]. World Health Organization Histological Classification of Lung and Pleural Tumours. 4th Edition.

UpToDate Contents

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1. 肺の大細胞神経内分泌癌 large cell neuroendocrine carcinoma of the lung
2. ドライバー変異が認められない進行非小細胞肺癌の初期マネージメントのための全身療法 systemic therapy for the initial management of advanced non small cell lung cancer without a driver mutation
3. 消化器における神経内分泌腫瘍の発生の病理、分類、および重症度分類 pathology classification and grading of neuroendocrine tumors arising in the digestive system
4. 肺悪性腫瘍の病理 pathology of lung malignancies
5. 原発不明の神経内分泌腫瘍 neuroendocrine cancer of unknown primary site

English Journal

Post-first-line FOLFOX chemotherapy for grade 3 neuroendocrine carcinoma.

Hadoux J1, Malka D1, Planchard D1, Scoazec JY1, Caramella C1, Guigay J1, Boige V1, Leboulleux S1, Burtin P1, Berdelou A1, Loriot Y1, Duvillard P1, Chougnet CN1, Déandréis D1, Schlumberger M1, Borget I2, Ducreux M2, Baudin E3.
Endocrine-related cancer.Endocr Relat Cancer.2015 Jun;22(3):289-98. doi: 10.1530/ERC-15-0075. Epub 2015 Mar 13.
There is no standard for second-line chemotherapy in poorly differentiated grade 3 neuroendocrine carcinoma (G3-NEC) patients. We analyzed the antitumor efficacy of 5-fluorouracil and oxaliplatin (FOLFOX) chemotherapy in this population. A single-center retrospective analysis of consecutive G3-NEC p
PMID 25770151
PMID 25989941

Challenges in the diagnosis and management of cervical neuroendocrine carcinoma.

Burzawa J1, Gonzales N, Frumovitz M.
Expert review of anticancer therapy.Expert Rev Anticancer Ther.2015 May 17:1-6. [Epub ahead of print]
Neuroendocrine carcinoma represents about 1% all cervical cancers accounting for 100-200 diagnoses annually in the USA. Although it is uncommon, it is an aggressive histologic subtype of this otherwise favorable disease. To date, there are no prospective studies or randomized trials specific to this
PMID 25980782

Japanese Journal

今月の症例高次機能障害・脳波異常を認め,肺癌術後改善を認めた傍腫瘍症候群の1例

奥野圭祐,大原麻耶,石黒太郎 [他]
日本内科学会雑誌 100(10), 3041-3043, 2011-10-10
NAID 40019038647

PS-075-5 甲状腺転移を来した肺原発large cell neuroendocrine carcinomaの1例(PS-075 ポスターセッション(75)甲状腺,第111回日本外科学会定期学術集会)

西隆,小田桐弘毅,西村顕正,赤坂治枝,諸橋聡子,袴田健一,鬼島宏
日本外科学会雑誌 112(臨時増刊号_1・2), 634, 2011-05-25
NAID 110008684832

「大細胞神経内分泌癌」

　　[★]

英: large cell neuroendocrine carcinoma
関: 肺癌

肺癌の大細胞癌に含まれる組織型で、神経内分泌腫瘍としての性格を有する。

参考2のThe 1999 World Health Organization/International Association for the Study of Lung Cancer Histological Classification of Lung and Pleural Tumoursによれば、本腫瘍は大細胞癌のvariant、つまりLarge cell neuroendocrine carcinomaとして分類されている。