イルソグラジン
- 関
- irsogladine maleate
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/04/11 10:52:49」(JST)
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Irsogladine
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Names |
IUPAC name
6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine
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Other names
DCPDAT
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Identifiers |
CAS Registry Number
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57381-26-7 |
ChemSpider |
3621 |
PubChem |
3752 |
Properties |
Molecular formula
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C9H7Cl2N5 |
Molar mass |
256.09 g·mol−1 |
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references |
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Irsogladine is a phosphodiesterase inhibitor.[1]
References
- ^ Satoh, H; Amagase, K; Takeuchi, K (2013). "Mucosal protective agents prevent exacerbation of NSAID-induced small intestinal lesions caused by antisecretory drugs in rats". The Journal of Pharmacology and Experimental Therapeutics 348 (2): 227–35. doi:10.1124/jpet.113.208991. PMID 24254524.
English Journal
- Irsogladine maleate, a gastric mucosal protectant, suppresses intestinal polyp development in Apc-mutant mice.
- Onuma W1,2, Tomono S3, Miyamoto S1, Fujii G4, Hamoya T1, Fujimoto K5, Miyoshi N3, Fukai F2, Wakabayashi K3, Mutoh M1,4.
- Oncotarget.Oncotarget.2016 Jan 30. doi: 10.18632/oncotarget.7082. [Epub ahead of print]
- This study aimed to identify gastric mucosal protectants that suppress intestinal tumorigenesis in a mouse model. We chose six gastric mucosal protectants (ecabet sodium hydrate, irsogladine maleate, rebamipide, sofalcone, teprenone and troxipide) and examined their effects on the activity of oxidat
- PMID 26840084
- Irsogladine maleate inhibits Porphyromonas gingivalis-mediated expression of toll-like receptor 2 and interleukin-8 in human gingival epithelial cells.
- Savitri IJ1, Ouhara K1, Fujita T1, Kajiya M1, Miyagawa T1, Kittaka M1, Yamakawa M1, Shiba H1, Kurihara H1.
- Journal of periodontal research.J Periodontal Res.2015 Aug;50(4):486-93. doi: 10.1111/jre.12231. Epub 2014 Sep 20.
- BACKGROUND AND OBJECTIVE: Periodontitis is an infectious disease caused by an interaction between the host and periodontopathogenic bacteria. Regulating the immune response in human gingival epithelial cells (HGEC) may contribute to the prevention of periodontitis. Irsogladine maleate (IM) has previ
- PMID 25244303
- Effect of long-term proton pump inhibitor therapy and healing effect of irsogladine on nonsteroidal anti-inflammatory drug-induced small-intestinal lesions in healthy volunteers.
- Kojima Y1, Takeuchi T1, Ota K1, Harada S1, Edogawa S1, Narabayashi K1, Nouda S1, Okada T1, Kakimoto K1, Kuramoto T1, Inoue T1, Higuchi K1.
- Journal of clinical biochemistry and nutrition.J Clin Biochem Nutr.2015 Jul;57(1):60-5. doi: 10.3164/jcbn.15-32. Epub 2015 Jun 17.
- This study assessed time-course changes of the small intestinal lesions during long-term treatment with diclofenac sodium plus omeprazole and the effects of irsogladine on such lesions. Thirty two healthy volunteers were treated with diclofenac sodium (75 mg/day) plus omeprazole (10 mg/day) for 6
- PMID 26236102
Japanese Journal
- Development and Characterization of Oral Spray for Stomatitis Containing Irsogladine Maleate
- Chemical and pharmaceutical bulletin 64(12), 1659-1665, 2016-12
- NAID 40021010447
- 周期性血小板減少症に薬剤関連性小腸粘膜障害を合併した1例
- Irsogladine Maleate Prevents Colitis in Interleukin-10 Gene-Deficient Mice by Reducing Interleukin-12 and -23 Production
Related Links
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