イオパミドール
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/04/13 16:30:44」(JST)
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Iopamidol
|
Systematic (IUPAC) name |
1-N,3-N-bis(1,3-dihydroxypropan-2-yl)-5-[(2S)-2-hydroxypropanamido]-2,4,6-triiodobenzene-1,3-dicarboxamide |
Clinical data |
AHFS/Drugs.com |
Micromedex Detailed Consumer Information |
Pregnancy
category
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- US: B (No risk in non-human studies)
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Legal status
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Routes of
administration
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Intravascular |
Identifiers |
CAS Registry Number
|
Y |
ATC code
|
V08AB04 |
PubChem |
CID 65492 |
DrugBank |
DB08947 N |
UNII |
JR13W81H44 N |
KEGG |
D01797 Y |
ChEBI |
CHEBI:31711 N |
ChEMBL |
CHEMBL1200932 N |
Chemical data |
Formula |
C17H22I3N3O8 |
Molecular mass
|
777.08 g/mol |
N (what is this?) (verify) |
Iopamidol (INN, tradenames Iopamiro, Isovue, Iopamiron, and Niopam) is a nonionic, low-osmolar iodinated contrast agent, developed by Bracco.
It is available in various concentrations, from 200 to 370 mgI/mL.
Clinical uses
Iopamidol is primarily used in the following:[1]
- Angiography throughout the cardiovascular system, including cerebral and peripheral arteriography, coronary arteriography and ventriculography, pediatric angiocardiography, selective visceral arteriography and aortography, peripheral venography (phlebography)
- Adult and pediatric intravenous excretory urography and intravenous adult and pediatric contrast enhancement of computed tomographic (CECT) head and body imaging
Nursing Considerations: Contrast is nephrotoxic, assess continually renal function. Make sure fluids are encouraged post operation to help the body rid the contrast from the kidneys. Assess patient for allergies to Iodine or Shellfish as the contrast is composed largely of Iodine.
References
- ^ Bracco Diagnostic Inc. (April 2004). "Iopamidol (Isovue) prescribing information (revised April 2004)". DailyMed. U.S. National Library of Medicine. Retrieved 2008-03-28.
External links
- Isovue (iopamidol) Injection, Solution
Contrast media (V08)
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X-ray and CT |
Iodinated,
Water soluble
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Nephrotropic,
high osmolar
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- Diatrizoic acid#
- Metrizoic acid
- Iodamide
- Iotalamic acid
- Ioxitalamic acid
- Ioglicic acid
- Acetrizoic acid
- Iocarmic acid
- Methiodal
- Diodone
|
|
Nephrotropic,
low osmolar
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- Metrizamide
- Iohexol#
- Ioxaglic acid
- Iopamidol
- Iopromide
- Iotrolan
- Ioversol
- Iopentol
- Iodixanol
- Iomeprol
- Iobitridol
- Ioxilan
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|
Hepatotropic
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- Iodoxamic acid
- Iotroxic acid
- Ioglycamic acid
- Adipiodone
- Iobenzamic acid
- Iopanoic acid
- Iocetamic acid
- Sodium iopodate
- Tyropanoic acid
- Calcium iopodate
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|
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Iodinated,
Water insoluble
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- Ethyl esters of iodised fatty acids
- Iopydol
- Propyliodone
- Iofendylate
- Lipiodol
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Non-iodinated
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|
|
|
MRI |
Paramagnetic
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- Gadolinium-based: Gadobenic acid
- Gadobutrol
- Gadodiamide
- Gadofosveset
- Gadolinium
- Gadopentetic acid
- Gadoteric acid
- Gadoteridol
- Gadoversetamide
- Gadoxetic acid
Other: Ferric ammonium citrate
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|
Superparamagnetic
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- Ferumoxsil
- Ferristene
- Iron oxide, nanoparticles
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Other
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|
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Ultrasound |
- Microspheres of human albumin
- Microparticles of galactose
- Perflenapent
- Microspheres of phospholipids
- Sulfur hexafluoride
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|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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UpToDate Contents
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- 1. 造影剤に対する即時型過敏反応:臨床症状、診断、および治療 immediate hypersensitivity reactions to radiocontrast media clinical manifestations diagnosis and treatment
- 2. 造影剤誘発性腎症の予防 prevention of contrast induced nephropathy
- 3. 造影剤に対する即時型過敏反応:再発反応の予防 immediate hypersensitivity reactions to radiocontrast media prevention of recurrent reactions
- 4. 造影剤誘発性腎症の病因、臨床的特徴、および診断 pathogenesis clinical features and diagnosis of contrast induced nephropathy
- 5. 急性静脈瘤出血患者における止血法 methods to achieve hemostasis in patients with acute variceal hemorrhage
English Journal
- Changes in mutagenicity and acute toxicity of solutions of iodinated X-ray contrast media during chlorination.
- Matsushita T1, Kobayashi N2, Hashizuka M2, Sakuma H2, Kondo T2, Matsui Y2, Shirasaki N2.
- Chemosphere.Chemosphere.2015 Sep;135:101-7. doi: 10.1016/j.chemosphere.2015.03.082. Epub 2015 Apr 27.
- In the present study, the effects of chlorination on the mutagenicity (assessed via the Ames assay) and acute toxicity (assessed via a bioluminescence inhibition assay) of solutions containing one of five commonly used iodinated X-ray contrast media (ICM) (iopamidol, iohexol, iopromide, iomeprol, an
- PMID 25917607
- A comparison of iopromide and iopamidol, two acidoCEST MRI contrast media that measure tumor extracellular pH.
- Moon BF1, Jones KM2, Chen LQ3, Liu P3, Randtke EA1, Howison CM1, Pagel MD1,3,4,5.
- Contrast media & molecular imaging.Contrast Media Mol Imaging.2015 Jun 25. doi: 10.1002/cmmi.1647. [Epub ahead of print]
- Acidosis within tumor and kidney tissues has previously been quantitatively measured using a molecular imaging technique known as acidoCEST MRI. The previous studies used iopromide and iopamidol, two iodinated contrast agents that are approved for clinical CT diagnoses and have been repurposed for a
- PMID 26108564
- Percutaneous transhepatic portal embolization using foam ethanolamine oleate and carbon dioxide (CO2): a pilot study.
- Inoue S1, Ikeda O2, Nakasone Y1, Beppu T3, Masuda T3, Yokoyama K1, Utsunomiya D1, Baba H3, Yamashita Y1.
- Acta radiologica (Stockholm, Sweden : 1987).Acta Radiol.2015 Jun 24. pii: 0284185115590285. [Epub ahead of print]
- BACKGROUND: Percutaneous transhepatic portal embolization (PTPE) can induce atrophy of the embolized- and hypertrophy of the residual area. These effects are advantageous in patients scheduled for extended hepatectomy.PURPOSE: To evaluate the clinical safety and effectiveness of foam sclerotherapy w
- PMID 26113740
Japanese Journal
- 非イオン性ヨード造影剤イオパミドールによる多発性固定薬疹の1例 (特集 薬疹・薬物障害)
- 超低出生体重児の重症胎便関連性腸閉塞症に対する外科的治療戦略
- 春本 研,塩川 智司,権 英寿,山道 拓,辻本 嘉助
- 日本小児外科学会雑誌 47(1), 20-25, 2011-02-20
- 【目的】超低出生体重児の重症胎便関連性腸閉塞症(以下本症)に対し,イオパミロン^[○!R]注腸療法を行った.腸閉塞状態の改善が得られなかった症例に対して,拡張した腸管の減圧目的で,クベース内で局所麻酔下に腸管皮膚瘻造設術を行った.その有用性を含めた本症に対する治療戦略を検討した.【対象】平成15年1月〜平成20年4月の5年間で,当院NICUに入院となった超低出生体重児は114例.そのうち本症が疑わ …
- NAID 110008506452
- 3D-CTを併用したセンチネルリンパ節同定を行った外陰部 Paget 病の3例
- 中浦 淳,緒方 大,片岡 照貴,吉川 周佐,清原 祥夫
- Skin cancer : official organ of the Japanese Society for Skin Cancer = 皮膚悪性腫瘍研究会機関誌 25(1), 101-104, 2010-05-15
- 今回,我々は外陰部Paget病におけるセンチネルリンパ節(以下,SLN)の同定に際し,Radio isotope法(以下,RI法),色素法に加え,CT用造影剤をトレーサーとして用いた3D-CTによるSLNの同定を行った。3D-CTを用いることでリンパ管とSLNとの関係,SLNの解剖学的位置を把握しやすくなり,術中にセンチネルリンパ節の位置をイメージしやすく,術者の助けに …
- NAID 10026549931
Related Links
- Iopamidol is in a group of drugs called radiopaque (RAY dee oh payk) contrast agents. Iopamidol contains iodine, a substance that absorbs x-rays. Radiopaque contrast agents are used to allow blood vessels, organs, and other non ...
- 1084 Iopamidol Injection / Official Monographs JP XVII peak areas of N,N?-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-hydroxyacetylamino-2,4,6-triiodoisophthalamide is not more than 1.0z. Loss on drying <2.41> Not more than 0.30z (1 ...
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