WordNet
- material such as sand or gravel used with cement and water to make concrete, mortar, or plaster
- a sum total of many heterogenous things taken together (同)congeries, conglomeration
- composed of a dense cluster of separate units such as carpels or florets or drupelets; "raspberries are aggregate fruits"
- formed of separate units gathered into a mass or whole; "aggregate expenses include expenses of all divisions combined for the entire year"; "the aggregated amount of indebtedness" (同)aggregated, aggregative, mass
- gather in a mass, sum, or whole (同)combine
- amount in the aggregate to
PrepTutorEJDIC
- …'を'集める / 総計(…に)なる《+『to』+『名』》 / 集まった,総計の / 集合体 / 〈U〉〈C〉(砂利など)骨材 / 《the ~》総計,総額
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- 1. 前頭側頭型認知症：疫学、病理学、および病因 frontotemporal dementia epidemiology pathology and pathogenesis
- 2. サラセミア症候群の分子病理 molecular pathology of the thalassemic syndromes
- 3. 腎移植におけるBKウイルス（ポリオーマウイルス）腎症の臨床症状および診断 clinical manifestations and diagnosis of bk virus induced polyomavirus induced nephropathy in kidney transplantation
- 4. HIV関連神経障害の疫学、病因および臨床症状 epidemiology pathogenesis and clinical features of hiv associated neuropathies
- 5. 家族性地中海熱の病態生理 pathophysiology of familial mediterranean fever
English Journal
- Polyglutamine aggregation in Huntington's disease and spinocerebellar ataxia type 3: similar mechanisms in aggregate formation.
- Seidel K1, Siswanto S1, Fredrich M1, Bouzrou M1, Brunt ER2, van Leeuwen FW3, Kampinga HH4, Korf HW1, Rüb U1, den Dunnen WF5.
- Neuropathology and applied neurobiology.Neuropathol Appl Neurobiol.2015 Jun 11. doi: 10.1111/nan.12253. [Epub ahead of print]
- AIMS: Polyglutamine (polyQ) diseases are characterized by the expansion of a polymorphic glutamine sequence in disease-specific proteins and exhibit aggregation of these proteins. This is combated by the cellular protein quality control (PQC) system, consisting of chaperone-mediated refolding as wel
- PMID 26095752
- Compartment-specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition.
- Miller SB1, Ho CT1, Winkler J1, Khokhrina M1, Neuner A2, Mohamed MY1, Guilbride DL2, Richter K3, Lisby M4, Schiebel E2, Mogk A5, Bukau B5.
- The EMBO journal.EMBO J.2015 Mar 12;34(6):778-97. doi: 10.15252/embj.201489524. Epub 2015 Feb 11.
- Disruption of the functional protein balance in living cells activates protective quality control systems to repair damaged proteins or sequester potentially cytotoxic misfolded proteins into aggregates. The established model based on Saccharomyces cerevisiae indicates that aggregating proteins in t
- PMID 25672362
- A knockin mouse model of spinocerebellar ataxia type 3 exhibits prominent aggregate pathology and aberrant splicing of the disease gene transcript.
- Ramani B1, Harris GM2, Huang R3, Seki T3, Murphy GG4, Costa Mdo C3, Fischer S3, Saunders TL5, Xia G6, McEachin RC7, Paulson HL8.
- Human molecular genetics.Hum Mol Genet.2015 Mar 1;24(5):1211-24. doi: 10.1093/hmg/ddu532. Epub 2014 Oct 15.
- Polyglutamine diseases, including spinocerebellar ataxia type 3 (SCA3), are caused by CAG repeat expansions that encode abnormally long glutamine repeats in the respective disease proteins. While the mechanisms underlying neurodegeneration remain uncertain, evidence supports a proteotoxic role for t
- PMID 25320121
Japanese Journal
- 神経変性疾患の治療展望とトレハロース(セミナー「様々なストレスへの交差的耐性の獲得-Cross Protection研究の現状と展望-」)
- 貫名 信行
- 低温生物工学会誌 52(1), 25-29, 2006-08-21
- … One of the pathological hallmarks in polyglutamine diseases is the formation of intranuclear inclusions of polyglutamine-containing proteins in the brain. …
- NAID 110006783012
- Adenovirusmediated expression of mutant DRPLA proteins with expanded polyglutamine stretches in neuronally differentiated PC12 cells. Preferential intranuclear aggregate formation and apoptosis
- SATO A
- Hum Mol Genet 8, 997-1006, 1999
- NAID 30018401325
- ジステンパー及び牛疫ウイルスの増殖に関する比較電子顕微鏡的研究
- 田島 正典 [他],本橋 常正,岸 茂,中村 惇治
- 日本獸醫學雜誌 33(1), 1-PLATE VIII, 1971-02-25
- ジステンパーおよび牛疫ウイルスの増殖を, 初代培養鶏胚細胞および Vero 細胞において, 形態学的に研究した, 両種ウイルスは, 染色標本において認められる細胞変性効果, 電子顕微鏡的に見られるウイルス粒子の微細構造およびウイルス粒子形成様式のすべての点において, 相互に良く類似していた. 両種ウイルスに感染した細胞において, 好酸性細胞質封入体と合胞体が, 感染の最初の表現として観察され, 約 …
- NAID 110003919201
Related Links
- Human Molecular Genetics, 1999, Vol. 8, No. 6 999 (Fig. 2). The percentages of cells containing the intranuclear aggregate bodies in the cells expressing the FLAG epitope
- We studied the development of neuronal intranuclear inclusions (NIIs), neuropil aggregates (NAs), and expression of expanded repeat polyglutamine protein in the
Related Pictures
★リンクテーブル★
| リンク元 | 「核内凝集体」 |
| 関連記事 | 「aggregate」「aggregated」「aggregating」「intranuclear」 |
「核内凝集体」
「aggregate」
- v.
- 凝集する、凝集した
- n.
「aggregated」
- adj.
- 凝集性の、塊状の
「aggregating」
- 集合性の
「intranuclear」
- 核内の