- 関
- nuclearly、subnuclear
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English Journal
- First report of a new alphaherpesvirus in a freshwater turtle (Pseudemys concinna concinna) kept in Germany.
- Jungwirth N1, Bodewes R2, Osterhaus AD2, Baumgärtner W1, Wohlsein P3.Author information 1Department of Pathology, University of Veterinary Medicine Hannover, Bünteweg 17, D-30559 Hannover, Germany.2Department of Viroscience, Erasmus MC, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.3Department of Pathology, University of Veterinary Medicine Hannover, Bünteweg 17, D-30559 Hannover, Germany. Electronic address: peter.wohlsein@tiho-hannover.de.AbstractHerpesviruses represent important pathogenic agents in zoological chelonian collections. Infections in tortoises are actually most commonly associated with necrotizing lesions in the upper digestive tract. Herpesvirus infections in sea turtles are most commonly associated with fibropapillomatosis, although other disease complexes caused by other herpesviruses have been described. Herpesviruses are known to cause latent infections and may be reactivated upon various endogenous or exogenous stimuli resulting in acute and sometimes fatal disease. The present description represents the first report about a new alphaherpesvirus found in a fresh water turtle (Pseudemys concinna concinna). The animal died suddenly without showing clinical signs. Macroscopically, no lesions typically associated with a herpesvirus infection were found. Light microscopic examination showed hepatic lipidosis and countless numbers of intranuclear inclusion bodies in hepatocytes as the only significant light microscopic lesion. Transmission electron microscopy revealed typical herpesvirus particles in the nucleus of hepatocytes. To further substantiate these observations a molecular identification using PCR followed by sequencing of the obtained fragments was performed. Phylogenetic analysis indicated a new alphaherpesvirus called Emydid herpesvirus 1.
- Veterinary microbiology.Vet Microbiol.2014 Jun 4;170(3-4):403-7. doi: 10.1016/j.vetmic.2014.02.029. Epub 2014 Mar 2.
- Herpesviruses represent important pathogenic agents in zoological chelonian collections. Infections in tortoises are actually most commonly associated with necrotizing lesions in the upper digestive tract. Herpesvirus infections in sea turtles are most commonly associated with fibropapillomatosis, a
- PMID 24667062
- Intranuclear cytoplasmic inclusions in cytologically suspicious or malignant thyroid nodules: identification and correlation with echogenicity and size of the nodules.
- Arena S1, Latina A, Stornello M, Saraceno G, Benvenga S.Author information 1A.S.P. 8 Siracusa, Section of Endocrinology and Metabolic Diseases, Department of Internal Medicine, Umberto I Hospital, Siracusa, Italy.AbstractIntranuclear inclusions (ICI) represent one cytological feature suggestive of malignancy. The aims of this study are (1) to correlate ICI with size and echogenicity of the thyroid nodules that, at fine-needle aspiration cytology (FNAC), are suspiciously malignant (THY4) or malignant (THY5); and (2) to ascertain whether ICI alone or combined with some ultrasonography (US) characteristics would help in predicting malignancy. We studied 90 consecutive thyroid nodules (THY4 n = 60 or THY5 n = 30) from 90 patients, who subsequently underwent thyroidectomy. Prior to thyroidectomy, all 90 nodules were examined by the US-guided FNAC. A cytology/histology correlation was performed. The results showed that 70 nodules were cancerous (82.2 %, THY4 = 73.3 %, THY5 = 100 %). ICI positive (ICI+) were 53/90 nodules (THY4 = 48.3 %, THY5 = 80.0 %), of which three (all THY4) were benign. The maximum diameter was smaller in the 53 ICI +ve than in the 37 ICI -ve nodules (14.2 ± 5.4 vs. 20.0 ± 9.4 mm, P = 0.0001; median volume 1.32 vs. 4.03 ml). In the THY4 smaller hypoechoic nodules, malignancy rate was 95 % with greater probability to detect ICI compared with non-hypoechoic nodules of >20 mm in maximum diameter (31 (75.6 %) vs. 4 (23.5 %), P = 0.0002). Based on the results, we conclude that ICI detection is associated with relatively smaller size and hypoechoic appearance in THY4 or THY5 nodules. In the THY4 nodules, when coupled with these US characteristics, ICI identification selects lesions with high chances of malignancy.
- Endocrine.Endocrine.2014 May;46(1):114-22. doi: 10.1007/s12020-013-0044-6. Epub 2013 Sep 25.
- Intranuclear inclusions (ICI) represent one cytological feature suggestive of malignancy. The aims of this study are (1) to correlate ICI with size and echogenicity of the thyroid nodules that, at fine-needle aspiration cytology (FNAC), are suspiciously malignant (THY4) or malignant (THY5); and (2)
- PMID 24065307
- Reduced excitatory amino acid transporter 1 and metabotropic glutamate receptor 5 expression in the cerebellum of fragile X mental retardation gene 1 premutation carriers with fragile X-associated tremor/ataxia syndrome.
- Pretto DI1, Kumar M2, Cao Z3, Cunningham CL4, Durbin-Johnson B5, Qi L5, Berman R6, Noctor SC7, Hagerman RJ8, Pessah IN9, Tassone F10.Author information 1Department of Biochemistry and Molecular Medicine, University of California Davis, School of Medicine, Sacramento, CA, USA; Department of Psychiatry and Behavioral Sciences, University of California Davis Medical Center, Sacramento, CA, USA.2Department of Biochemistry and Molecular Medicine, University of California Davis, School of Medicine, Sacramento, CA, USA.3Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.4Department of Psychiatry and Behavioral Sciences, University of California Davis Medical Center, Sacramento, CA, USA.5Department of Public Health Sciences, University of California Davis, School of Medicine, Davis, CA, USA.6Department of Neurological Surgery, School of Medicine, University of California Davis, Davis, CA, USA.7Department of Pathology, School of Medicine, University of California Davis, Davis CA, USA; Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California Davis School of Medicine, Sacramento, CA, USA.8Department of Pediatrics, School of Medicine, University of California Davis, Davis CA, USA; Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California Davis School of Medicine, Sacramento, CA, USA.9Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, USA; Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California Davis School of Medicine, Sacramento, CA, USA.10Department of Biochemistry and Molecular Medicine, University of California Davis, School of Medicine, Sacramento, CA, USA; Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California Davis School of Medicine, Sacramento, CA, USA. Electronic address: ftassone@ucdavis.edu.AbstractA premutation (PM) expansion (55-200 CGG) in the fragile X mental retardation gene 1 causes elevated messenger RNA and reduced fragile X mental retardation gene 1 protein. Young PM carriers can develop characteristic physical features and mild cognitive disabilities. In addition, individuals with PM, particularly male carriers, are at high risk to develop fragile X-associated tremor/ataxia syndrome (FXTAS) with aging. Human postmortem FXTAS brains show extensive white matter disease in the cerebellum and the presence of intranuclear inclusions throughout the brain, although their etiologic significance is unknown. In the current work, expression levels of the metabotropic glutamate (Glu) receptor 5 and the Glu transporter excitatory amino acid transporter 1, examined by reverse transcription polymerase chain reaction and western blot analyses, were found to be reduced in the postmortem cerebellum of PM carriers with FXTAS compared with age matched controls, with higher CGG repeat number having greater reductions in both proteins. These data suggests a dysregulation of Glu signaling in PM carriers, which would likely contribute to the development and severity of FXTAS.
- Neurobiology of aging.Neurobiol Aging.2014 May;35(5):1189-97. doi: 10.1016/j.neurobiolaging.2013.11.009. Epub 2013 Nov 16.
- A premutation (PM) expansion (55-200 CGG) in the fragile X mental retardation gene 1 causes elevated messenger RNA and reduced fragile X mental retardation gene 1 protein. Young PM carriers can develop characteristic physical features and mild cognitive disabilities. In addition, individuals with PM
- PMID 24332449
Japanese Journal
- 山口 博樹
- 日本医科大学医学会雑誌 11(3), 136-144, 2015
- … TCAB1, which transports the telomerase complex to intranuclear Cajal bodies; …
- NAID 130005087586
- 乳頭癌様の異型細胞を認めた甲状腺腺腫様結節の 1 例
- 成富 真理,畠 榮,物部 泰昌,高須賀 博久,日野 寛子
- 日本臨床細胞学会雑誌 54(2), 153-157, 2015
- 背景 : 甲状腺穿刺吸引細胞診で, 大型細胞, 核形不整, 核内細胞質封入体がみられ, 乳頭癌との鑑別に苦慮した腺腫様結節の 1 例を経験したので報告する. 症例 : 60 歳代, 男性. 検診で左甲状腺腫瘤を指摘され当院受診. 超音波で左葉上極に分葉状腫瘤を認め, 乳頭癌あるいは腺腫様甲状腺腫を疑い, 穿刺吸引細胞診が施行された. 組織球を背景に, 濾胞上皮細胞が大～小集塊でシート状に出現してい …
- NAID 130005071172
Related Links
- in·tra·nu·cle·ar / ˌɪn trəˈnu kli ər, -ˈnyu- or, by metathesis,-kyə lər / Show Spelled [in-tr uh-noo-klee-er, - nyoo - or, by metathesis,-ky uh-ler] Show IPA adjective existing or taking place within a nucleus. Origin: 1885–90; intra-+ nuclear
- in·tra·nu·cle·ar (in'tră-nū'klē-ăr), Within the nucleus of a cell. ... The small cell variant of melanoma consists of dissociate cells with spindly appearances, prominent nucleoli and intranuclear inclusions, which were not seen in our ...
★リンクテーブル★
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核内の、(物理)素粒子の
- 関
- elementary particle、intranuclear、nuclearly
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- 英
- intranuclear、subnuclear、nuclearly
- 関
- 素粒子
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- 関
- intranuclear、subnuclear
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- 関
- intranuclear inclusion body、nuclear inclusion、nuclear inclusion body
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- 関
- intranuclear inclusion、nuclear inclusion、nuclear inclusion body
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