核間性眼筋麻痺 INO
WordNet
- paralysis of the motor nerves of the eye
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/12/20 17:34:52」(JST)
[Wiki en表示]
Internuclear ophthalmoplegia |
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Schematic demonstrating right internuclear ophthalmoplegia, caused by injury of the right medial longitudinal fasciculus. |
Classification and external resources |
Specialty |
ophthalmology |
ICD-10 |
H51.2 |
ICD-9-CM |
378.86 |
DiseasesDB |
6853 |
[edit on Wikidata]
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Internuclear ophthalmoplegia (INO) is a disorder of conjugate lateral gaze in which the affected eye shows impairment of adduction. When an attempt is made to gaze contralaterally (relative to the affected eye), the affected eye adducts minimally, if at all. The contralateral eye abducts, however with nystagmus. Additionally, the divergence of the eyes leads to horizontal diplopia. That is, if the right eye is affected the patient will "see double" when looking to the left, seeing two images side-by-side. Convergence is generally preserved.[1]
Contents
- 1 Causes
- 2 Variants
- 3 See also
- 4 References
- 5 External links
Causes
The disorder is caused by injury or dysfunction in the medial longitudinal fasciculus (MLF), a heavily-myelinated tract that allows conjugate eye movement by connecting the paramedian pontine reticular formation (PPRF)-abducens nucleus complex of the contralateral side to the oculomotor nucleus of the ipsilateral side.
In young patients with bilateral INO, multiple sclerosis is often the cause. In older patients with one-sided lesions a stroke is a distinct possibility. Other causes are possible.[2]
Variants
A rostral lesion within the midbrain may affect the convergence center thus causing bilateral divergence of the eyes which is known as the WEBINO syndrome ( Wall Eyed Bilateral INO)[3] as each eye looks at the opposite "wall".
If the lesion affects the PPRF (or the abducens nucleus) and the MLF on the same side (the MLF having crossed from the opposite side), then the "one and a half syndrome" occurs which, simply put, involves paralysis of all conjugate horizontal eye movements other than abduction of the eye on the opposite side to the lesion.
See also
- Multiple sclerosis
- One and a half syndrome
References
- ^ "Internuclear Ophtalmoplegia".
- ^ Keane JR (May 2005). "Internuclear ophthalmoplegia: unusual causes in 114 of 410 patients". Arch. Neurol. 62 (5): 714–7. doi:10.1001/archneur.62.5.714. PMID 15883257.
- ^ Lana MA, Moreira PR, Neves LB (December 1990). "Wall-eyed bilateral internuclear ophthalmoplegia (Webino syndrome) and myelopathy in pyoderma gangrenosum". Arq Neuropsiquiatr. 48 (4): 497–501. PMID 2094199.
External links
- 1611005961 at GPnotebook
- Animation at mrcophth.com
Lesions of spinal cord and brain
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Spinal cord/
vascular myelopathy |
- sensory: Sensory ataxia
- Tabes dorsalis
- motor: Motor neurone disease
- mixed: Brown-Séquard syndrome
- cord syndrome (Posterior
- Anterior
- Central/Syringomyelia)
- Subacute combined degeneration of spinal cord (B12)
- Cauda equina syndrome
- Anterior spinal artery syndrome
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Brainstem |
Medulla (CN 8, 9, 10, 12) |
- Lateral medullary syndrome/Wallenberg
- Medial medullary syndrome/Dejerine
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Pons (CN 5, 6, 7, 8) |
- Upper dorsal pontine syndrome/Raymond Céstan syndrome
- Lateral pontine syndrome (AICA) (lateral)
- Medial pontine syndrome/Millard-Gubler syndrome/Foville's syndrome(basilar)
- Locked-in syndrome
- Internuclear ophthalmoplegia
- One and a half syndrome
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Midbrain (CN 3, 4) |
- Weber's syndrome
- Benedikt syndrome
- Parinaud's syndrome
- Nothnagel's syndrome
- Claude's syndrome
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Other |
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Cerebellum |
- lateral (Dysmetria
- Dysdiadochokinesia
- Intention tremor)
- medial (Cerebellar ataxia)
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Basal ganglia |
- Chorea
- Dystonia
- Parkinson's disease
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Cortex |
- ACA syndrome
- MCA syndrome
- PCA syndrome
- frontal lobe: Expressive aphasia
- Aboulia
- parietal lobe: Receptive aphasia
- Hemispatial neglect
- Gerstmann syndrome
- Astereognosis
- occipital lobe: Bálint's syndrome
- Cortical blindness
- Pure alexia
- temporal lobe: Cortical deafness
- Prosopagnosia
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Thalamus |
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Other |
- Subclavian steal syndrome
- Upper motor neurone lesion (Clasp-knife response)
- Lower motor neurone lesion
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UpToDate Contents
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English Journal
- ALS-Plus syndrome: Non-pyramidal features in a large ALS cohort.
- McCluskey L1, Vandriel S1, Elman L1, Van Deerlin VM2, Powers J1, Boller A1, Wood EM2, Woo J3, McMillan CT1, Rascovsky K1, Grossman M4.
- Journal of the neurological sciences.J Neurol Sci.2014 Oct 15;345(1-2):118-24. doi: 10.1016/j.jns.2014.07.022. Epub 2014 Jul 18.
- OBJECTIVE: Autopsy studies show widespread pathology in amyotrophic lateral sclerosis (ALS), but clinical surveys of multisystem disease in ALS are rare. We investigated ALS-Plus syndrome, an understudied group of patients with clinical features extending beyond pyramidal and neuromuscular systems w
- PMID 25086858
- Clinicopathological study of three cases of infantile fibromatosis of the orbit.
- Hayashi K1, Katori N, Otsuki Y, Ohno-Matsui K.
- International ophthalmology.Int Ophthalmol.2014 Oct;34(5):1097-106. doi: 10.1007/s10792-014-9915-y. Epub 2014 Feb 15.
- We report the clinical and pathological findings in three infants with infantile fibromatosis that involved several extraocular muscles which led to disorders of ocular motility. We also describe their clinical features before and after surgery. This was a retrospective interventional case study wit
- PMID 24535563
- Vertical gaze-evoked nystagmus and internuclear ophthalmoplegia as sole manifestations in paramedian pontine infarction.
- Kim HA1, Lee H.
- Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.Neurol Sci.2014 Oct;35(10):1619-21. doi: 10.1007/s10072-014-1808-3. Epub 2014 Apr 26.
- PMID 24770935
Japanese Journal
- Infarction of the Abducens Nucleus and Facial Nerve
- 小脳性運動失調と顔面感覚障害を合併したwall-eyed bilateral internuclear ophthalmoplegia(WEBINO)症候群の85歳男性例
- 核上性,核間性眼球運動障害 : MLF,Fisher症候群を含めて (特集 眼位・眼球運動異常の診断と治療)
Related Links
- Internuclear ophthalmoplegia (INO) is a disorder of conjugate lateral gaze in which the affected eye shows impairment of adduction. When an attempt is made to gaze contralaterally (relative to the affected eye), the affected eye ...
- Internuclear ophthalmoparesis (INO), also commonly referred to as intranuclear ophthalmoplegia, is a specific gaze abnormality characterized by impaired horizontal eye movements with weak adduction of the affected eye, and ...
Related Pictures
★リンクテーブル★
[★]
- 関
- convergence insufficiency、internuclear ophthalmoplegia、ocular motility disorder、oculomotor nerve palsy、opsoclonus、Parinaud syndrome、Parinaud's syndrome、skew deviation
[★]
- 関
- eye movement disorder、internuclear ophthalmoplegia、ocular motility disorder、opsoclonus、Parinaud syndrome、Parinaud's syndrome、skew deviation
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眼球運動障害
- 関
- convergence insufficiency、eye movement disorder、internuclear ophthalmoplegia、oculomotor nerve palsy、opsoclonus、Parinaud syndrome、Parinaud's syndrome、skew deviation
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- 英
- internuclear ophthalmoplegia, INO
- 同
- 核間性麻痺
- 関
- 内側縦束症候群
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- 英
- internuclear ophthalmoplegia INO
- ラ
- ophthalmoplegia internuclearis
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眼筋麻痺 = ophthalm plegia