IL-3
WordNet
- any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/05/24 18:28:34」(JST)
[Wiki en表示]
IL3 |
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Available structures |
PDB |
Human UniProt search: PDBe RCSB |
List of PDB id codes |
1JLI
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Identifiers |
Aliases |
IL3, interleukin 3, IL-3, MCGF, MULTI-CSF |
External IDs |
OMIM: 147740 HomoloGene: 47938 GeneCards: 3562 |
Gene ontology |
Molecular function |
• growth factor activity
• interleukin-3 receptor binding
• cytokine activity
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Cellular component |
• extracellular region
• intracellular
• extracellular space
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Biological process |
• positive regulation of DNA replication
• activation of MAPKK activity
• MAPK cascade
• embryonic hemopoiesis
• epidermal growth factor receptor signaling pathway
• fibroblast growth factor receptor signaling pathway
• neurotrophin TRK receptor signaling pathway
• insulin receptor signaling pathway
• axon guidance
• cell-cell signaling
• positive regulation of myeloid leukocyte differentiation
• vascular endothelial growth factor receptor signaling pathway
• small GTPase mediated signal transduction
• Fc-epsilon receptor signaling pathway
• nervous system development
• positive regulation of tyrosine phosphorylation of Stat5 protein
• positive regulation of peptidyl-tyrosine phosphorylation
• positive regulation of mast cell proliferation
• cytokine-mediated signaling pathway
• innate immune response
• Ras protein signal transduction
• immune response
• positive regulation of cell proliferation
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Sources:Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) |
Chr 5: 132.06 – 132.06 Mb |
n/a |
PubMed search |
[1] |
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Wikidata |
View/Edit Human |
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Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene.[1][2]
Contents
- 1 Function
- 2 Discovery
- 3 Interactions
- 4 See also
- 5 References
- 6 Further reading
Function
Interleukin 3 is an interleukin, a type of biological signal (cytokine) that can improve the body's natural response to disease as part of the immune system. It acts by binding to the interleukin-3 receptor.
Interleukin 3 stimulates the differentiation of multipotent hematopoietic stem cells into myeloid progenitor cells or, with the addition of IL-7, into lymphoid progenitor cells. In addition, IL-3 stimulates proliferation of all cells in the myeloid lineage (granulocytes, monocytes, and dendritic cells), in conjunction with other cytokines, e.g., Erythropoietin (EPO), Granulocyte macrophage colony-stimulating factor (GM-CSF), and IL-6. It is secreted by basophils and activated T cells to support growth and differentiation of T cells from the bone marrow in an immune response. Activated T cells can either induce their own proliferation and differentiation (autocrine signalling), or that of other T cells (paracrine signalling) - both involve IL-2 binding to the IL-2 receptor on T cells (upregulated upon cell activation, under the induction of macrophage-secreted IL-1). The human IL-3 gene encodes a protein 152 amino acids long, and the naturally occurring IL-3 is glycosylated. The human IL-3 gene is located on chromosome 5, only 9 kilobases from the GM-CSF gene, and its function is quite similar to GM-CSF.
Discovery
Interleukin 3 originally was discovered by JN Ihle in mice. He found a T cell derived factor that induced the synthesis of 20alpha-hydroxysteroid dehydrogenase in hematopoietic cells and termed it interleukin-3.[3][4]
Interactions
Interleukin 3 has been shown to interact with IL3RA.[5][6]
See also
References
- ^ "Entrez Gene: IL3 interleukin 3 (colony-stimulating factor, multiple)".
- ^ Yang YC, Ciarletta AB, Temple PA, Chung MP, Kovacic S, Witek-Giannotti JS, Leary AC, Kriz R, Donahue RE, Wong GG (October 1986). "Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3". Cell 47 (1): 3–10. doi:10.1016/0092-8674(86)90360-0. PMID 3489530.
- ^ Ihle JN, Pepersack L, Rebar L (June 1981). "Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from athymic mice by a unique lymphokine". J. Immunol. 126 (6): 2184–9. PMID 6971890.
- ^ Ihle JN, Weinstein Y, Keller J, Henderson L, Palaszynski E (1985). "Interleukin 3". Meth. Enzymol. Methods in Enzymology 116: 540–52. doi:10.1016/S0076-6879(85)16042-8. ISBN 978-0-12-182016-9. PMID 3003517.
- ^ Stomski FC, Sun Q, Bagley CJ, Woodcock J, Goodall G, Andrews RK, Berndt MC, Lopez AF (June 1996). "Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding". Mol. Cell. Biol. 16 (6): 3035–46. PMC 231298. PMID 8649415.
- ^ Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF (November 1994). "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF". EMBO J. 13 (21): 5176–85. PMC 395466. PMID 7957082.
Further reading
- Wagemaker G, Burger H, van Gils FC, van Leen RW, Wielenga JJ (1990). "Interleukin-3". Biotherapy 2 (4): 337–45. doi:10.1007/BF02170083. PMID 2268499.
- Martinez-Moczygemba M, Huston DP (2003). "Biology of common beta receptor-signaling cytokines: IL-3, IL-5, and GM-CSF". J. Allergy Clin. Immunol. 112 (4): 653–65; quiz 666. doi:10.1016/j.jaci.2003.08.015. PMID 14564341.
- Mroczko B, Szmitkowski M (2004). "Hematopoietic cytokines as tumor markers". Clin. Chem. Lab. Med. 42 (12): 1347–54. doi:10.1515/CCLM.2004.253. PMID 15576295.
- Kitamura T, Sato N, Arai K, Miyajima A (1991). "Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors". Cell 66 (6): 1165–74. doi:10.1016/0092-8674(91)90039-2. PMID 1833064.
- Urdal DL, Price V, Sassenfeld HM, Cosman D, Gillis S, Park LS (1989). "Molecular characterization of colony-stimulating factors and their receptors: human interleukin-3". Ann. N. Y. Acad. Sci. 554: 167–76. doi:10.1111/j.1749-6632.1989.tb22418.x. PMID 2544122.
- Otsuka T, Miyajima A, Brown N, Otsu K, Abrams J, Saeland S, Caux C, de Waal Malefijt R, de Vries J, Meyerson P (1988). "Isolation and characterization of an expressible cDNA encoding human IL-3. Induction of IL-3 mRNA in human T cell clones". J. Immunol. 140 (7): 2288–95. PMID 3127463.
- Yang YC, Ciarletta AB, Temple PA, Chung MP, Kovacic S, Witek-Giannotti JS, Leary AC, Kriz R, Donahue RE, Wong GG (1986). "Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3". Cell 47 (1): 3–10. doi:10.1016/0092-8674(86)90360-0. PMID 3489530.
- Le Beau MM, Epstein ND, O'Brien SJ, Nienhuis AW, Yang YC, Clark SC, Rowley JD (1987). "The interleukin 3 gene is located on human chromosome 5 and is deleted in myeloid leukemias with a deletion of 5q". Proc. Natl. Acad. Sci. U.S.A. 84 (16): 5913–7. doi:10.1073/pnas.84.16.5913. PMC 298973. PMID 3497400.
- Dorssers L, Burger H, Bot F, Delwel R, Geurts van Kessel AH, Löwenberg B, Wagemaker G (1987). "Characterization of a human multilineage-colony-stimulating factor cDNA clone identified by a conserved noncoding sequence in mouse interleukin-3". Gene 55 (1): 115–24. doi:10.1016/0378-1119(87)90254-X. PMID 3497843.
- Chirmule N, Goonewardena H, Pahwa S, Pasieka R, Kalyanaraman VS, Pahwa S (1995). "HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells". J. Biol. Chem. 270 (33): 19364–9. doi:10.1074/jbc.270.33.19364. PMID 7642615.
- Than S, Oyaizu N, Pahwa RN, Kalyanaraman VS, Pahwa S (1994). "Effect of human immunodeficiency virus type-1 envelope glycoprotein gp160 on cytokine production from cord-blood T cells". Blood 84 (1): 184–8. PMID 8018916.
- Le Beau MM, Espinosa R, Neuman WL, Stock W, Roulston D, Larson RA, Keinanen M, Westbrook CA (1993). "Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases". Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5484–8. doi:10.1073/pnas.90.12.5484. PMC 46745. PMID 8516290.
- Stomski FC, Sun Q, Bagley CJ, Woodcock J, Goodall G, Andrews RK, Berndt MC, Lopez AF (1996). "Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding". Mol. Cell. Biol. 16 (6): 3035–46. PMC 231298. PMID 8649415.
- Feng Y, Klein BK, McWherter CA (1996). "Three-dimensional solution structure and backbone dynamics of a variant of human interleukin-3". J. Mol. Biol. 259 (3): 524–41. doi:10.1006/jmbi.1996.0337. PMID 8676386.
- Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD (1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4330–5. doi:10.1073/pnas.94.9.4330. PMC 20722. PMID 9113989.
- Klein BK, Feng Y, McWherter CA, Hood WF, Paik K, McKearn JP (1997). "The receptor binding site of human interleukin-3 defined by mutagenesis and molecular modeling". J. Biol. Chem. 272 (36): 22630–41. doi:10.1074/jbc.272.36.22630. PMID 9278420.
- Sanchez X, Suetomi K, Cousins-Hodges B, Horton JK, Navarro J (1998). "CXC chemokines suppress proliferation of myeloid progenitor cells by activation of the CXC chemokine receptor 2". J. Immunol. 160 (2): 906–10. PMID 9551928.
- Tabira T, Chui DH, Fan JP, Shirabe T, Konishi Y (1998). "Interleukin-3 and interleukin-3 receptors in the brain". Ann. N. Y. Acad. Sci. 840: 107–16. doi:10.1111/j.1749-6632.1998.tb09554.x. PMID 9629242.
- Nilsen EM, Johansen FE, Jahnsen FL, Lundin KE, Scholz T, Brandtzaeg P, Haraldsen G (1998). "Cytokine profiles of cultured microvascular endothelial cells from the human intestine". Gut 42 (5): 635–42. doi:10.1136/gut.42.5.635. PMC 1727090. PMID 9659156.
Cell signaling: cytokines
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By family |
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By function/
cell |
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Cytokines, glycoproteins: colony-stimulating factors
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CFU-GEMM |
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CFU-GM |
- Granulocyte macrophage colony-stimulating factor
- Granulocyte colony-stimulating factor
- Macrophage colony-stimulating factor
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CFU-E |
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CFU-Meg |
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UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
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English Journal
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- Cho J1, Bing SJ1, Kim A2, Lee NH3, Byeon SH3, Kim GO4, Jee Y1.
- Pharmaceutical biology.Pharm Biol.2017 Dec;55(1):306-319.
- PMID 27927068
- Interleukin-3 Prevents Cellular Death Induced by Oxidative Stress in HEK293 Cells.
- López C1, Zamorano P1, Teuber S1, Salas M1, Otth C2,3, Hidalgo MA4, Concha I1, Zambrano A1,3.
- Journal of cellular biochemistry.J Cell Biochem.2017 Jun;118(6):1330-1340. doi: 10.1002/jcb.25790. Epub 2017 Jan 10.
- PMID 27862234
- A Chemically Inducible Helper Module for Detecting Protein-Protein Interactions with Tunable Sensitivity Based on KIPPIS.
- Kashima D1, Kawade R1, Nagamune T1, Kawahara M1.
- Analytical chemistry.Anal Chem.2017 Apr 13. doi: 10.1021/acs.analchem.6b04063. [Epub ahead of print]
- PMID 28382822
Japanese Journal
- Constitutive exposure of phosphatidylserine on viable cells.
- Segawa Katsumori,Suzuki Jun,Nagata Shigekazu
- Proceedings of the National Academy of Sciences of the United States of America 108(48), 19246-19251, 2011-11-29
- … They efficiently responded to interleukin 3 and underwent apoptosis upon treatment with Fas ligand. …
- NAID 120003674044
- インターロイキン3(IL-3),IL-4,IL-5 (広範囲 血液・尿化学検査 免疫学的検査(第7版・4)その数値をどう読むか) -- (プロスタノイド,サイトカイン,増殖因子,ケモカイン)
- The Effects of X-Irradiation on Ex Vivo Expansion of Cryopreserved Human Hematopoietic Stem/Progenitor Cells
- Hayashi Naoki,Takahashi Kenji,Kashiwakura Ikuo
- Journal of radiation research 51(2), 137-144, 2010-03-16
- … After cryopreservation with the optimal procedure, 2 Gy-irradiated HSPCs were cultured with or without stromal cells supplemented with combination of interleukin-3, stem cell factor, and thrombopoietin. …
- NAID 10025914531
Related Links
- Interleukin 3, also known as IL-3, is a protein that in humans is encoded by the IL3 gene. Contents. 1 Function; 2 Discovery; 3 Interactions; 4 See also; 5 References; 6 Further reading. [edit] Function. Interleukin-3 (IL-3) is an interleukin , a type ...
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★リンクテーブル★
[★]
- 英
- interleukin-3
- 同
- インターロイキン-3、インターロイキン3
- 関
- サイトカイン、インターロイキン
産生細胞
機能
- 造血初期に相乗効果的に働く
- IL-3は肥満細胞の増殖分化を誘導
- IL-3 KOマウスでは肥満細胞がない
受容体
[★]
- 関
- IL-3 receptor、IL3 receptor
[★]
[★]
インターロイキン IL
[★]
インターロイキン IL