- 関
- IL3 receptor、interleukin-3 receptor
WordNet
- the 9th letter of the Roman alphabet (同)i
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- 『私は』私が
- iodineの化学記号
- =sense organ / 受信装置
- Illinois
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/03/15 14:10:38」(JST)
[Wiki en表示]
interleukin 3 receptor, alpha |
Identifiers |
Symbol |
IL3RA |
Alt. symbols |
CD123 |
HUGO |
6012 |
OMIM |
308385 |
Other data |
Locus |
Chr. X p22.3 |
interleukin 3 receptor, Y-Chromosomal |
Identifiers |
Symbol |
IL3RA |
Alt. symbols |
IL3RY, IL3RAY |
Entrez |
3563 |
HUGO |
6012 |
OMIM |
430000 |
Other data |
Locus |
Chr. Y p11.3 |
The interleukin-3 receptor (also known as CD123 antigen) is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune system.
The gene coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes.
The receptor belongs to the type I cytokine receptor family and is a heterodimer with a unique alpha chain paired with the common beta (beta c or CD131) subunit.
The gene for the alpha subunit is 40 kilobases long and has 12 exons.
The receptor, found on pluripotent progenitor cells, induces tyrosine phosphorylation within the cell and promotes proliferation and differentiation within the hematopoietic cell lines.
External links[edit]
- Interleukin-3 Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
Cytokine receptors
|
|
Chemokine receptor
(GPCRs) |
CC |
- CCR1 / CCRL1
- CCR2
- CCRL2
- CCR3
- CCR4
- CCR5
- CCR6
- CCR7
- CCR8
- CCR9
- CCR10
|
|
CXC |
- IL-8
- CXCR3
- CXCR4
- CXCR5
- CXCR6
- CXCR7
|
|
Other |
|
|
|
TNF receptor |
1-10 |
- TNFRSF1 (CD120)
- TNFRSF1A (CD120a)
- TNFRSF1B (CD120b)
- TNFRSF3 (Lymphotoxin beta receptor)
- TNFRSF4 (CD134)
- TNFRSF5 (CD40)
- TNFRSF6 (FAS)
- TNFRSF6B
- TNFRSF7 (CD27)
- TNFRSF8 (CD30)
- TNFRSF9 (CD137)
|
|
11-20 |
- TNFRSF10A (CD261)
- TNFRSF10B (CD262)
- TNFRSF10C (CD263)
- TNFRSF10D (CD264)
- TNFRSF11A (CD265/RANK)
- TNFRSF11B (Osteoprotegerin)
- TNFRSF12A (CD266)
- TNFRSF13B (CD267)
- TNFRSF13C
- TNFRSF14 (CD268)
- TNFRSF16 (Nerve growth factor receptor)
- TNFRSF17 (CD269)
- TNFRSF18
- TNFRSF19
|
|
21-25 |
- TNFRSF21
- TNFRSF25
- TNFRSF27
|
|
|
JAK-STAT |
Type I |
γ-chain |
- Interleukin receptors
- IL2R / IL2RA/IL2RB / IL15R
- IL4R / IL13R / IL13RA1 / IL13RA2
- IL7R / IL7RA
- IL9R
- IL21R
|
|
β-chain |
- Interleukin receptors
- IL3R / IL3RA
- IL5R / IL5RA
- GM-CSF
|
|
gp130 |
- Interleukin receptors
- IL6RA
- 11/IL11RA
- 27/IL27RA
- OSMR
- LIFR
- CNTFR
|
|
IL12RB1 |
- Interleukin receptors
- IL12R/IL12RB1/IL12RB2
- IL23R23
|
|
Other |
- hormone receptor: GH
- prolactin
|
|
|
Type II |
- Interleukin receptors
- IL10R / IL10RA / IL10RB / IL22R / IL22RA1 / IL22RA2
- IL20R / IL20RA / IL20RB
- IL28R
- Interferon receptors
- -α/β / IFNAR1/IFNAR2
- -γ/IFNGR1 / IFNGR2
|
|
|
Ig superfamily |
- CSF1
- KIT
- IL1
- IL18R / IL18R1
|
|
IL 17 family |
- IL-17
- IL17RA
- IL17RB
- IL17RC
- IL17RD
- IL17RE
|
|
S/T |
|
|
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. 赤血球産生調節 regulation of erythropoiesis
- 2. 組換え造血成長因子の概要 introduction to recombinant hematopoietic growth factors
- 3. 骨髄造血の制御 regulation of myelopoiesis
- 4. 先天性赤血球増多症および真性多血症の分子学的病因 molecular pathogenesis of congenital polycythemic disorders and polycythemia vera
- 5. 小児における肺胞蛋白症 pulmonary alveolar proteinosis in children
English Journal
- Dampened ERK signaling in hematopoietic progenitor cells in rheumatoid arthritis.
- Colmegna I, Pryshchep S, Oishi H, Goronzy JJ, Weyand CM.SourceDepartment of Medicine, Division of Immunology and Rheumatology, Stanford University, USA.
- Clinical immunology (Orlando, Fla.).Clin Immunol.2012 Apr;143(1):73-82. Epub 2012 Jan 28.
- In rheumatoid arthritis (RA), hematopoietic progenitor cells (HPC) have age-inappropriate telomeric shortening suggesting premature senescence and possible restriction of proliferative capacity. In response to hematopoietic growth factors RA-derived CD34(+) HPC expanded significantly less than age-m
- PMID 22342385
- Immunophenotypic analysis of myeloperoxidase-negative leukemia cutis and blastic plasmacytoid dendritic cell neoplasm.
- Cronin DM, George TI, Reichard KK, Sundram UN.SourceDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
- American journal of clinical pathology.Am J Clin Pathol.2012 Mar;137(3):367-76.
- Myeloid leukemia cutis (LC) and blastic plasmacytoid dendritic cell neoplasm (BPDCN) are morphologically indistinguishable malignancies that frequently manifest in the skin. Separating myeloperoxidase-negative LC from BPDCN may be particularly challenging. We identified a panel of immunohistochemica
- PMID 22338048
Japanese Journal
- SLP76と好塩基球の活性化 (特集 マスト細胞・好塩基球の活性化をめぐって)
- Derivation of functional mature neutrophils from human embryonic stem cells
- Yokoyama Yasuhisa,Suzuki Takahiro,Sakata-Yanagimoto Mamiko,Kumano Keiki,Higashi Katsumi,Takato Tsuyoshi,Kurokawa Mineo,Ogawa Seishi,Chiba Shigeru,横山 泰久,坂田(柳元) 麻実子,千葉 滋
- Blood 113(26), 6584-6592, 2009-06
- … Embryoid bodies were formed with bone morphogenic protein-4, stem cell factor (SCF), Flt-3 ligand (FL), interleukin (IL) -6/IL-6 receptor fusion protein (FP6), and thrombopoietin (TPO). … Cells derived from the embryoid bodies were cultured on a layer of irradiated OP9 cells with a combination of SCF, FL, FP6, IL-3, and TPO, which was later changed to granulocyte-colony stimulating factor. …
- NAID 120001466696
Related Links
- IL-3 receptor expression, regulation and function in cells of the vasculature. Korpelainen EI, Gamble JR, Vadas MA, Lopez AF. Division of Human Immunology, Hanson Centre for Cancer Research, Adelaide, South Australia. IL- 3 is a ...
- CD123 (alpha-subunit of IL-3 receptor) expression on primitive and committed human hematopoietic cells was studied by multicolor sorting and single-cell culture. The sources of cells included fetal liver (FLV), fetal bone marrow, umbilical ...
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- 英
- interleukin-3 receptor、IL-3 receptor
- 関
- インターロイキン3レセプター、IL-3受容体、IL-3レセプター
[★]
- 英
- interleukin-3 receptor、IL-3 receptor
- 関
- インターロイキン3受容体、IL-3受容体、IL-3レセプター
[★]
- 英
- IL-3 receptor
- 関
- インターロイキン3受容体、インターロイキン3レセプター、IL-3レセプター
[★]
- 英
- IL-3 receptor
- 関
- インターロイキン3受容体、インターロイキン3レセプター、IL-3受容体
[★]
- 関
- IL-3 receptor、IL3 receptor
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