同: Interleukin-3 receptor, α-chain

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/08/14 08:59:14」(JST)

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The interleukin-3 receptor (also known as CD123 antigen) is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune system.

The gene coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes.

The receptor belongs to the type I cytokine receptor family and is a heterodimer with a unique alpha chain paired with the common beta (beta c or CD131) subunit.

The gene for the alpha subunit is 40 kilobases long and has 12 exons.

Cell types and function

The receptor, found on pluripotent progenitor cells, induces tyrosine phosphorylation within the cell and promotes proliferation and differentiation within the hematopoietic cell lines. It can be found on basophils and pDCs as well as some cDCs among peripheral blood mononuclear cells.

CD123 is expressed across acute myeloid leukemia (AML) subtypes, including leukemic stem cells.^[1]

Possible drug target

An experimental antibody-drug conjugate SGN-CD123A targets CD123 as a possible treatment for AML.^[1]

References

^ ^a ^b Seattle Genetics Initiates Phase 1 Trial of SGN-CD123A for Patients with Relapsed or Refractory Acute Myeloid Leukemia Sept 2016

External links

Interleukin-3 Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

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1. 芽球性形質細胞様樹状細胞腫瘍 blastic plasmacytoid dendritic cell neoplasm
2. 有毛細胞白血病の臨床的特徴および診断 clinical features and diagnosis of hairy cell leukemia
3. T細胞前リンパ球性白血病の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of t cell prolymphocytic leukemia
4. B細胞前リンパ球性白血病 b cell prolymphocytic leukemia
5. ナチュラルキラー（NK）細胞大顆粒リンパ球性白血病 natural killer nk cell large granular lymphocyte leukemia

English Journal

Conjunctival extranodal natural killer/t-cell lymphoma, nasal type.

Kiratli H1, Uzun S, Yeşilirmak A, Ayhan AS, Soylemezoğlu F.
Cornea.Cornea.2015 Jun;34(6):710-2. doi: 10.1097/ICO.0000000000000420.
PURPOSE: To report a rare case of a patient with isolated primary conjunctival extranodal natural killer/T-cell lymphoma, nasal type (ENKTCL) without nasal involvement.METHODS: The clinical course, magnetic resonance imaging, positron emission tomographic and immunohistopathological features of the
PMID 25811726

Blastic plasmacytoid dendritic cell neoplasm: skin and bone marrow infiltration of three cases and the review of the literature.

Atalay F1, Demirci GT2, Bayramgürler D3, Ateşoğlu EB4, Yıldız S5.
Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion.Indian J Hematol Blood Transfus.2015 Jun;31(2):302-6. doi: 10.1007/s12288-014-0464-3. Epub 2014 Oct 14.
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a distinct and rare neoplastic entity and was classified as a subgroup of acute myeloblastic leukemia by the WHO in 2008. The median survival of patients was 15.2 months in a large case series. Allogeneic or autologous bone marrow transplantat
PMID 25825579

A CD3xCD123 bispecific DART for redirecting host T cells to myelogenous leukemia: Preclinical activity and safety in nonhuman primates.

Chichili GR1, Huang L1, Li H1, Burke S1, He L1, Tang Q1, Jin L1, Gorlatov S1, Ciccarone V1, Chen F1, Koenig S1, Shannon M1, Alderson R1, Moore PA1, Johnson S1, Bonvini E2.
Science translational medicine.Sci Transl Med.2015 May 27;7(289):289ra82. doi: 10.1126/scitranslmed.aaa5693.
Current therapies for acute myeloid leukemia (AML) are largely ineffective, and AML patients may benefit from targeted immunotherapy approaches. MGD006 is a bispecific CD3xCD123 dual-affinity re-targeting (DART) molecule that binds T lymphocytes and cells expressing CD123, an antigen up-regulated in
PMID 26019218

Japanese Journal

Th1/Th2 関連疾患における末梢血樹状細胞サブセットの解析

林ゆめ子
Dokkyo journal of medical sciences 40(1), T13-T22, 2013-03-25
… 究では,Th1疾患であるサルコイドーシス( サ症)( n=30)とTh2疾患であるアトピー性疾患( n=23)における末梢血DC サブセットを,健常人 (n=23)と比較して検討した.フローサイトメトリーを用いて末梢血中のmDC(CD11c+),pDC( CD123+),mDC1( CD1a+),mDC2( CD141+)のサブセット解析を行った.サ症群では総DC, mDC の数が有意に低下していた.mDC/pDC 比は3 群間で差がなかった.CD1a+mDC は,サ症群では対照群と差がなかったが,アトピー群ではCD1a+mDC …
NAID 110009561263

Leukemic Manifestation of Blastic Plasmacytoid Dendritic Cell Neoplasm Lacking Skin Lesion : A Borderline Case between Acute Monocytic Leukemia

TAKIUCHI Yoko,MARUOKA Hayato,AOKI Kazunari,KATO Aiko,ONO Yuichiro,NAGANO Seiji,ARIMA Hiroshi,INOUE Daichi,MORI Minako,TABATA Sumie,YANAGITA Soshi,MATSUSHITA Akiko,NISHIO Mari,IMAI Yukihiro,ITO Kiminari,FUJITA Haruyuki,KADOWAKI Norimitsu,ISHIKAWA Takayuki,TAKAHASHI Takayuki,Takahashi Takayuki
Journal of clinical and experimental hematopathology 52(2), 107-111, 2012-10-01
… These cells were positive for CD4, CD86, CD123 (bright), BDCA-2, and HLA-DR, but negative for CD1a, CD3, CD11b, CD11c, CD13, CD14, CD19, CD64, and CD68. …
NAID 10031120434

Blastic Plasmacytoid Dendritic Cell Neoplasm : Report of Two Cases

TSUNODA Kanako,SATOH Takashi,AKASAKA Kiyomi,ISHIKAWA Yuichi,ISHIDA Yoji,MASUDA Tomoyuki,AKASAKA Toshihide
Journal of clinical and experimental hematopathology 52(1), 23-29, 2012-05-01
… Histopathology of a skin biopsy specimen and immunohistochemistry demonstrated that the tumor cells were small to medium-sized with a blastoid morphology and positive for CD4, CD56, CD123 and T-cell leukemia-1 (TCL-1). … Although immunohistochemistry of the infiltrating tumor cells demonstrated positivity for CD4, CD56, CD123 and TCL-1, the cells were large with a distinct nucleolus, and different from those of typical BPDCN. …
NAID 10030615559

Related Pictures

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