インターロイキン3受容体、インターロイキン3レセプター

関: IL-3 receptor、IL3 receptor

WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system

PrepTutorEJDIC

=sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/15 17:44:51」(JST)

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[Wiki en表示]

The interleukin-3 receptor (also known as CD123 antigen) is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune system.

The gene coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes.

The receptor belongs to the type I cytokine receptor family and is a heterodimer with a unique alpha chain paired with the common beta (beta c or CD131) subunit.

The gene for the alpha subunit is 40 kilobases long and has 12 exons.

The receptor, found on pluripotent progenitor cells, induces tyrosine phosphorylation within the cell and promotes proliferation and differentiation within the hematopoietic cell lines.

External links

Interleukin-3 Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

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English Journal

IL-1β inhibits ILC3 while favoring NK-cell maturation of umbilical cord blood CD34(+) precursors.

Ambrosini P1,2, Loiacono F2,3, Conte R2, Moretta L3, Vitale C1,2, Mingari MC1,2.
European journal of immunology.Eur J Immunol.2015 Jul;45(7):2061-71. doi: 10.1002/eji.201445326. Epub 2015 May 12.
NK cells are innate lymphocytes characterized by the expression of nuclear factor interleukin 3 regulated (NFIL3 or E4BP4), eomesodermin (EOMES) transcription factors (TFs), and by the ability to exert cytolytic activity and release IFN-γ. In the haploidentical-hematopoietic stem cell transplantati
PMID 25847448

Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice.

Lee EM1, Yee D1, Busfield SJ2, McManus JF3, Cummings N4, Vairo G2, Wei A4, Ramshaw HS5, Powell JA6, Lopez AF5, Lewis ID7, McCall MN1, Lock RB8.
Haematologica.Haematologica.2015 Jul;100(7):914-26. doi: 10.3324/haematol.2014.113092.
The prognosis of older patients with acute myelogenous leukemia is generally poor. The interleukin-3 receptor α-chain (CD123) is highly expressed on the surface of acute leukemia cells compared with normal hematopoietic stem cells. CSL362 is a fully humanized, CD123-neutralizing monoclonal antibody
PMID 26130514

Aberrant expression of CD123 (interleukin-3 receptor-α) on neoplastic mast cells.

Pardanani A1, Lasho T1, Chen D2, Kimlinger TK1, Finke C1, Zblewski D1, Patnaik MM1, Reichard KK2, Rowinsky E3, Hanson CA2, Brooks C3, Tefferi A1.
Leukemia.Leukemia.2015 Jul;29(7):1605-8. doi: 10.1038/leu.2015.16. Epub 2015 Feb 2.
PMID 25640886

Japanese Journal

Expression of Cytokine Receptors in Pre-implantation Mouse Embryos

, ,
Journal of Mammalian Ova Research 21(3), 128-133, 2004
… In this study, we investigated the expression of the cytokine receptors that activate Jak2, i.e., the receptors for prolactin (PrlR), growth hormone (GHR), tumor necrosis factor (TNFR), interleukin-3 (IL-3R), interleukin-5 (IL-5R), and granulocyte-macrophage colony stimulating factor (GM-CSFR). …
NAID 130004837098

Defects of Granulopoiesis in Patients with Severe Congenital Neutropenia

Kazuhiro NAKAMURA 1) Masao KOBAYASHI 2) Nakao KONISHI 1) Hiroshi KAWAGUCHI 1) Shin-ichiro MIYAGAWA 1) Takashi SATO 1) Osamu KATOH 3) and Kazuhiro UEDA 1)
Hiroshima journal of medical sciences 51(3), 63-74, 2002-09-10
… In all SCN patientsstudied no abnormalities of granulocyte colony-stimulating factor receptor (G-CSFR) genewere detected by polymerase chain reaction-single-strand conformation polymorphism analysisand sequence analysis. … A flow cytometric analysis of bone marrow cells based on theexpression of CD34, Kit receptor, and G-CSFR demonstrated a reduced frequency ofCD34+/Kit+/G-CSFR+ cells in patients with SCN. …
NAID 110000008701

The role of disulfide-linked dimerization in interleukin-3 receptor signaling and biological activity

LE F.
J. Biol. Chem. 275, 5124-5130, 2000
NAID 80011513567

「IL-3 receptor」

interleukin 3 receptor, Y-Chromosomal
Identifiers
Symbol	IL3RA
Alt. symbols	IL3RY, IL3RAY
Entrez	3563
HUGO	6012
OMIM	430000
Other data
Locus	Chr. Y p11.3

interleukin 3 receptor, alpha
Identifiers
Symbol	IL3RA
Alt. symbols	CD123
HUGO	6012
OMIM	308385
Other data
Locus	Chr. X p22.3

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インターロイキン3受容体、インターロイキン3レセプター、IL-3受容体、IL-3レセプター

関: IL3 receptor、interleukin-3 receptor

「インターロイキン3受容体」

　　[★]

英: interleukin-3 receptor、IL-3 receptor
関: インターロイキン3レセプター、IL-3受容体、IL-3レセプター

「インターロイキン3レセプター」

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英: interleukin-3 receptor、IL-3 receptor
関: インターロイキン3受容体、IL-3受容体、IL-3レセプター

「interleukin-3 receptor alpha subunit」

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インターロイキン3受容体αサブユニット

「interleukin」

　　[★] インターロイキン IL 　

「interleukins」