insulin receptor substrate

• インスリン受容体基質、インスリンレセプター基質、インシュリン受容体基質、インシュリンレセプター基質

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IRS

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IRS

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IRS

WordNet

1. the substance that is acted upon by an enzyme or ferment
2. a surface on which an organism grows or is attached; "the gardener talked about the proper substrate for acid-loving plants" (同)substratum
3. an indigenous language that contributes features to the language of an invading people who impose their language on the indigenous population; "the Celtic languages of Britain are a substrate for English" (同)substratum
4. any stratum or layer lying underneath another (同)substratum
5. hormone secreted by the isles of Langerhans in the pancreas; regulates storage of glycogen in the liver and accelerates oxidation of sugar in cells
6. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

1. インシュリン(膵臓(すいぞう)ホルモンで糖尿病治療剤)
2. =sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/24 12:06:42」(JST)

wiki en

[Wiki en表示]

Insulin receptor substrate (IRS) is an important ligand in the insulin response of human cells.

IRS-1, for example, is an IRS protein that contains a phosphotyrosine binding-domain (PTB-domain). In addition, the insulin receptor contains a NPXY motif. The PTB-domain binds the NPXY sequence. Thus, the insulin receptor binds IRS.

Genes

• IRS1 (see also Insulin receptor substrate 1)
• IRS2 (see also Insulin receptor substrate 2)
• IRS3P - a pseudogene
• IRS4

References

• van der Geer P, Wiley S, Pawson T (1999). "Re-engineering the target specificity of the insulin receptor by modification of a PTB domain binding site". Oncogene 18 (20): 3071–5. doi:10.1038/sj.onc.1202879. PMID 10340378. 

UpToDate Contents

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• 1. インスリン受容体の構造および機能 structure and function of the insulin receptor
• 2. インスリン様成長因子Iの生理学 physiology of insulin like growth factor 1
• 3. 2型糖尿病の病因 pathogenesis of type 2 diabetes mellitus
• 4. インスリン作用 insulin action
• 5. 非アルコール性脂肪性肝疾患の病因 pathogenesis of nonalcoholic fatty liver disease

English Journal

• Chronic central leptin infusion modulates the glycemia response to insulin administration in male rats through regulation of hepatic glucose metabolism.

• Burgos-Ramos E1, Canelles S2, Rodríguez A3, Gómez-Ambrosi J3, Frago LM2, Chowen JA2, Frühbeck G3, Argente J2, Barrios V4.
• Molecular and cellular endocrinology.Mol Cell Endocrinol.2015 Nov 5;415:157-72. doi: 10.1016/j.mce.2015.08.014. Epub 2015 Aug 18.
• Leptin and insulin use overlapping signaling mechanisms to modify hepatic glucose metabolism, which is critical in maintaining normal glycemia. We examined the effect of an increase in central leptin and insulin on hepatic glucose metabolism and its influence on serum glucose levels. Chronic leptin
• PMID 26296906

• Metabolic, anabolic, and mitogenic insulin responses: A tissue-specific perspective for insulin receptor activators.

• Bedinger DH1, Adams SH2.
• Molecular and cellular endocrinology.Mol Cell Endocrinol.2015 Nov 5;415:143-56. doi: 10.1016/j.mce.2015.08.013. Epub 2015 Aug 12.
• Insulin acts as the major regulator of the fasting-to-fed metabolic transition by altering substrate metabolism, promoting energy storage, and helping activate protein synthesis. In addition to its glucoregulatory and other metabolic properties, insulin can also act as a growth factor. The metabolic
• PMID 26277398

• Post-translational regulation of PTEN catalytic function and protein stability in the hibernating 13-lined ground squirrel.

• Wu CW1, Bell RA1, Storey KB2.
• Biochimica et biophysica acta.Biochim Biophys Acta.2015 Nov;1850(11):2196-202. doi: 10.1016/j.bbagen.2015.07.004. Epub 2015 Jul 17.
• BACKGROUND: The insulin signaling pathway functions as a major regulator of many metabolic and cellular functions, and has been shown to be reversibly suppressed in many species during hibernation. This study characterized the regulation of PTEN phosphatase, a negative regulator of the insulin recep
• PMID 26189697

Japanese Journal

• Insulin/IRS2/PI3-K pathwayとメタボリックシンドローム

• 腎臓内科・泌尿器科 = Nephrology & urology 5(2), 185-192, 2017-02
• NAID 40021107981

• Polymorphisms of insulin receptor substrate 2 are putative biomarkers for pediatric medulloblastoma : considering the genetic susceptibility and pathological diagnoses

• Nagoya Journal of Medical Science 79(1), 47-54, 2017-02
• NAID 120005972913

• Fucoidan from sea cucumber Cucumaria frondosa exhibits anti-hyperglycemic effects in insulin resistant mice via activating the PI3K/PKB pathway and GLUT4

• Journal of bioscience and bioengineering 121(1), 36-42, 2016-01
• NAID 110010041300

Related Links

• insulin receptor substrate-1 - definition of insulin receptor ...

insulin receptor substrate-1 a cytoplasmic protein that is a direct substrate of the activated insulin receptor kinase. Insulin exposure results in its rapid phosphorylation at multiple tyrosine residues. Its phosphorylated sites associate ...

• IRS1 - Insulin receptor substrate 1 - Homo sapiens (Human)

May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or ...

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★リンクテーブル★

リンク元	「インシュリン受容体基質」「インスリンレセプター基質」「インシュリンレセプター基質」「IRS」「インスリン受容体基質」
拡張検索	「insulin receptor substrates」
関連記事	「substrate」

「インシュリン受容体基質」

　　[★]

英

insulin receptor substrate、IRS

関

インスリン受容体基質、インスリンレセプター基質、インシュリンレセプター基質

「インスリンレセプター基質」

　　[★]

英

insulin receptor substrate

関

インシュリン受容体基質、インスリン受容体基質、インシュリンレセプター基質

「インシュリンレセプター基質」

　　[★]

英

insulin receptor substrate

関

インシュリン受容体基質、インスリン受容体基質、インスリンレセプター基質

「IRS」

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• 内毛根鞘 inner root sheath
• インスリン受容体基質 insulin receptor substrate

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Intergroup Rhabdomyosarcoma Study

「インスリン受容体基質」

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英

insulin receptor substrate, IRS

関

インスリン

• IRS-1
• IRS-2

「insulin receptor substrates」

　　[★] インスリン受容体基質 IRSs

「substrate」

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• n.

• 基質

関

matrices、matrix、stroma