インスリン受容体基質 IRSs
WordNet
- the substance that is acted upon by an enzyme or ferment
- a surface on which an organism grows or is attached; "the gardener talked about the proper substrate for acid-loving plants" (同)substratum
- an indigenous language that contributes features to the language of an invading people who impose their language on the indigenous population; "the Celtic languages of Britain are a substrate for English" (同)substratum
- any stratum or layer lying underneath another (同)substratum
- hormone secreted by the isles of Langerhans in the pancreas; regulates storage of glycogen in the liver and accelerates oxidation of sugar in cells
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- インシュリン(膵臓(すいぞう)ホルモンで糖尿病治療剤)
- =sense organ / 受信装置
UpToDate Contents
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- 1. インスリン受容体の構造および機能 structure and function of the insulin receptor
- 2. 2型糖尿病の病因 pathogenesis of type 2 diabetes mellitus
- 3. インスリン作用 insulin action
- 4. インスリン様成長因子1の生理学 physiology of insulin like growth factor 1
- 5. 脂肪異栄養症症候群 lipodystrophic syndromes
English Journal
- Application of network construction to estimate functional changes to insulin receptor substrates 1 and 2 in Huh7 cells following infection with the hepatitis C virus.
- Liu J1, Wang L2, Wang W1, Li Y1, Jia X1, Zhai S1, Shi J1, Dang S1.
- Molecular medicine reports.Mol Med Rep.2016 Sep;14(3):2379-88. doi: 10.3892/mmr.2016.5527. Epub 2016 Jul 18.
- Hepatitis C virus (HCV) is closely associated with insulin resistance (IS), acting primarily by interfering with insulin signaling pathways, increasing cytokine-mediated (tumor necrosis factor α, interleukin 6) inflammatory responses and enhancing oxidative stress. In the insulin signaling pathw
- PMID 27432476
- Insulin Attenuates Beta-Amyloid-Associated Insulin/Akt/EAAT Signaling Perturbations in Human Astrocytes.
- Han X1, Yang L2, Du H3, Sun Q1, Wang X1, Cong L1, Liu X1, Yin L1, Li S1, Du Y4.
- Cellular and molecular neurobiology.Cell Mol Neurobiol.2016 Aug;36(6):851-64. doi: 10.1007/s10571-015-0268-5. Epub 2015 Sep 10.
- The excitatory amino acid transporters 1 and 2 (EAAT1 and EAAT2), mostly located on astrocytes, are the main mediators for glutamate clearance in humans. Malfunctions of these transporters may lead to excessive glutamate accumulation and subsequent excitotoxicity to neurons, which has been implicate
- PMID 26358886
- ROS1 fusions in cancer: a review.
- Uguen A1,2,3, De Braekeleer M1,2,4.
- Future oncology (London, England).Future Oncol.2016 Aug;12(16):1911-28. doi: 10.2217/fon-2016-0050. Epub 2016 Jun 3.
- The ROS1 gene belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. A literature review identified a ROS1 fusion in 2.54% of the patients with lung adenocarcinoma and even higher frequencies in spitzoid neoplasms and inflammatory myofibroblastic tumors. At present, 26 genes w
- PMID 27256160
Japanese Journal
- インスリン受容体基質を含む巨大分子複合体を介した新しいインスリン様活性調節機構
- バイオサイエンスとインダストリー 74(1), 21-25, 2016
- NAID 40020705836
- Upregulation of IRS-1 Expression in Goto-Kakizaki Rats Following Roux-en-Y Gastric Bypass Surgery : Resolution of Type 2 Diabetes?
- Tohoku journal of experimental medicine 225(3), 179-186, 2011-11-01
- NAID 10030196122
- メタボリックシンドローム発症基盤としてのインスリン抵抗性 インスリン抵抗性発現にかかわる因子 インスリン受容体および受容体基質の異常 (メタボリックシンドローム(第2版)--基礎・臨床の最新知見) -- (成因と病態生理)
- 日本臨床 69(-), 145-149, 2011-01
- NAID 40018269625
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「substrate」
- n.