WordNet

hormone secreted by the isles of Langerhans in the pancreas; regulates storage of glycogen in the liver and accelerates oxidation of sugar in cells
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

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インシュリン(膵臓(すいぞう)ホルモンで糖尿病治療剤)
=sense organ / 受信装置

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/03/20 11:53:32」(JST)

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The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of tyrosine kinase receptors.^[1] Metabolically, the insulin receptor plays a key role in the regulation of glucose homeostasis, a functional process that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer.^[2]^[3] Biochemically, the insulin receptor is encoded by a single gene INSR, from which alternate splicing during transcription results in either IR-A or IR-B isoforms.^[4] Downstream post-translational events of either isoform result in the formation of a proteolytically cleaved α and β subunit, which upon combination are ultimately capable of homo or hetero-dimerisation to produce the ≈320 kDa disulfide-linked transmembrane insulin receptor.^[4]

Structure

Initially, transcription of alternative splice variants derived from the INSR gene are translated to form one of two monomeric isomers; IR-A in which exon 11 is excluded, and IR-B in which exon 11 is included. Inclusion of exon 11 results in the addition of 12 amino acids upstream of the inherit furin protyolytic cleavage site.

Colour-coded schematic of the insulin receptor

Upon receptor dimerisation, after protyolytic cleavage into the α- and β-chains, the additional 12 amino acids remain present at the C-terminus of the α-chain (designated αCT) where they are predicted to influence receptor–ligand interaction.^[5]

Each isometric monomer is structurally organized into 8 distinct domains consists of; a leucine-rich repeat domain (L1, residues 1-157), a cyctine rich region (CR, residues 158-310), an additional leucine rich repeat domain (L2, residues 311-470), three fibronectin type III domains; FnIII-1 (residues 471-595), FnIII-2 (residues 596-808) and FnIII-3 (residues 809-906). Additionally, an insert domain (ID, residues 638-756) resides within FnIII-2, containing the α/β furin cleavage site, from which proteolysis results in both IDα and IDβ domains. Within the β-chain, downstream of the FnIII-3 domain lies a transmembrane helix (TH) and intracellular juxtamembrane (JM) region, just upstream of the intracellular tyrosine kinase (TK) catalytic domain, responsible for subsequent intracellular signaling pathways.^[6]

Upon cleavage of the monomer to its respective α- and β-chains, receptor hetero or homo-dimerisation is maintained covalently between chains by a single disulphide link and between monomers in the dimer by two disulphide links extending from each α-chain. The overall 3D ectodomain structure, possessing four ligand binding sites, resembles an inverted ‘V’, with the each monomer rotated approximately 2-fold about an axis running parallel to the inverted 'V' and L2 and FnIII-1 domains from each monomer forming the inverted 'V's apex.^[6]^[7]

Ligand binding

The insulin receptors endogenous ligands include insulin, IGF-I and IGF-II. The binding of ligand to the α-chains of the IR ectodomain induces a structural changes within the receptor leading to autophosphorylation of various tyrosine residues within the intracellular TK domain of the β-chain. These changes facilitate the recruitment of specific adapter proteins such as the insulin receptor substrate proteins (IRS) in addition to Src, Src Homology 2 - B (SH2-B), APS and proteins phosphatases including PTP1B, eventually promoting those downstream processes involving blood glucose homeostasis.^[8]

Scheme depicting possible IR binding sites

Strictly speaking the relationship between IR and ligand shows complex allosteric properties. This was indicated with the use of a Scatchard plots which identified that the measurement of the ratio of IR bound ligand to unbound ligand does not follow a linear relationship with respect to changes in the concentration of IR bound ligand, suggesting that the IR and its respective ligand share a relationship of cooperative binding.^[9] Furthermore, the observation that the rate of IR-ligand dissociation is accelerated upon addition of unbound ligand implies that the nature of this cooperation is negative; said differently, that the initial binding of ligand to the IR inhibits further binding to its second active site - exhibition of allosteric inhibition.^[9]

Although the precise binding mechanism of IR and its ligand has not yet been elucidated structurally, as identified using a systems biology approach, biologically relevant prediction of the IR-ligand kinetics (insulin/IGF-I) has been identified in the context of the currently available IR ectodomain structure.^[6]^[7]

These models state that each IR monomer possesses 2 insulin binding sites; site 1, which binds to the 'classical' binding surface of insulin: consisting of L1 plus αCT domains and site 2, consisting of loops at the junction of FnIII-1 and FnIII-2 predicted to bind to the 'novel' hexamer face binding site of insulin.^[1] As each monomer contributing to the IR ectodomain exhibits 3D 'mirrored' complementarity, N-terminal site 1 of one monomer ultimately faces C-terminal site 2 of the second monomer, where this is also true for each monomers mirrored complement (the opposite side of the ectodomain structure). Current literature distinguishes the complement binding sites by designating the second monomer's site 1 and site 2 nomenclature as either site 3 and site 4 or as site 1' and site 2' respectively.^[1]^[8]

As such, these models state that each IR may bind to an insulin molecule (which has two binding surfaces) via 4 locations, being site 1, 2, (3/1') or (4/2'). As each site 1 proximally faces site 2, upon insulin binding to a specific site, 'crosslinking' via ligand between monomers is predicted to occur (i.e. as [monomer 1 Site 1 - Insulin - monomer 2 Site (4/2')] or as [monomer 1 Site 2 - Insulin - monomer 2 site (3/1')]). In accordance with current mathematical modelling of IR-insulin kinetics, there are two important consequences to the events of insulin crosslinking; 1. that by the aforementioned observation of negative cooperation between IR and its ligand that subsequent binding of ligand to the IR is reduced and 2. that the physical action of crosslinking brings the ectodomain into such a conformation that is required for intracellular tyrosine phosphorylation events to ensue (i.e. these events serve as the requirements for receptor activation and eventual maintenance of blood glucose homeostasis).^[8]

Biological significance

Tyrosine kinase receptors, including the insulin receptor, mediate their activity by causing the addition of a phosphate group to particular tyrosines on certain proteins within a cell. The "substrate" proteins that are phosphorylated by the Insulin Receptor include a protein called "IRS-1" for "insulin receptor substrate 1". IRS-1 binding and phosphorylation eventually leads to an increase in the high affinity glucose transporter (Glut4) molecules on the outer membrane of insulin-responsive tissues, including muscle cells and adipose tissue, and therefore to an increase in the uptake of glucose from blood into these tissues. In other words, the glucose transporter Glut4 is transported from cellular vesicles to the cell surface, where it then can mediate the transport of glucose into the cell.

Effect of insulin on glucose uptake and metabolism. Insulin binds to its receptor (1), which, in turn, starts many protein activation cascades (2). These include: translocation of Glut-4 transporter to the plasma membrane and influx of glucose (3), glycogen synthesis (4), glycolysis (5), and fatty acid synthesis (6).

Pathology

The main activity of activation of the insulin receptor is inducing glucose uptake. For this reason "insulin insensitivity", or a decrease in insulin receptor signaling, leads to diabetes mellitus type 2 – the cells are unable to take up glucose, and the result is hyperglycemia (an increase in circulating glucose), and all the sequelae that result from diabetes.

Patients with insulin resistance may display acanthosis nigricans.

A few patients with homozygous mutations in the INSR gene have been described, which causes Donohue syndrome or Leprechaunism. This autosomal recessive disorder results in a totally non-functional insulin receptor. These patients have low-set, often protuberant, ears, flared nostrils, thickened lips, and severe growth retardation. In most cases, the outlook for these patients is extremely poor, with death occurring within the first year of life. Other mutations of the same gene cause the less severe Rabson-Mendenhall syndrome, in which patients have characteristically abnormal teeth, hypertrophic gingiva (gums), and enlargement of the pineal gland. Both diseases present with fluctuations of the glucose level: After a meal the glucose is initially very high, and then falls rapidly to abnormally low levels.^[10]

Regulation of gene expression

The activated IRS-1 acts as a secondary messenger within the cell to stimulate the transcription of insulin-regulated genes. First, the protein Grb2 binds the P-Tyr residue of IRS-1 in its SH2 domain. Grb2 is then able to bind SOS, which in turn catalyzes the replacement of bound GDP with GTP on Ras, a G protein. This protein then begins a phosphorylation cascade, culminating in the activation of mitogen-activated protein kinase (MAPK), which enters the nucleus and phosphorylates various nuclear transcription factors (such as Elk1).

Stimulation of glycogen synthesis

Glycogen synthesis is also stimulated by the insulin receptor via IRS-1. In this case, it is the SH2 domain of PI-3 kinase (PI-3K) that binds the P-Tyr of IRS-1. Now activated, PI-3K can convert the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP₂) to phosphatidylinositol 3,4,5-triphosphate (PIP₃). This indirectly activates a protein kinase, PKB (Akt), via phosphorylation. PKB then phosphorylates several target proteins, including glycogen synthase kinase 3 (GSK-3). GSK-3 is responsible for phosphorylating (and thus deactivating) glycogen synthase. When GSK-3 is phosphorylated, it is deactivated, and prevented from deactivating glycogen synthase. In this roundabout manner, insulin increases glycogen synthesis.

Degradation of insulin

Once an insulin molecule has docked onto the receptor and effected its action, it may be released back into the extracellular environment or it may be degraded by the cell. Degradation normally involves endocytosis of the insulin-receptor complex followed by the action of insulin degrading enzyme. Most insulin molecules are degraded by liver cells. It has been estimated that a typical insulin molecule is finally degraded about 71 minutes after its initial release into circulation.^[11]

Interactions

Insulin receptor has been shown to interact with Ectonucleotide pyrophosphatase/phosphodiesterase 1,^[12] PTPN11,^[13]^[14] GRB10,^[15]^[16]^[17]^[18]^[19] GRB7,^[20] PRKCD,^[21]^[22] IRS1,^[23]^[24] SH2B1^[25]^[26] and Mothers against decapentaplegic homolog 2.^[27]

References

^ ^a ^b ^c Ward CW, Lawrence MC (April 2009). "Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor". BioEssays 31 (4): 422–34. doi:10.1002/bies.200800210. PMID 19274663.
^ Ebina Y, Ellis L (April 1985). "The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling.". Cell 40 (4): 747–58. doi:10.1016/0092-8674(85)90334-4. PMID 2859121.
^ Malaguarnera R, Belfiore A (February 2012). "Proinsulin Binds with High Affinity the Insulin Receptor Isoform A and Predominantly Activates the Mitogenic Pathway.". Endocrinology. Epub. doi:10.1210/en.2011-1843. PMID 22355074.
^ ^a ^b Belfiore A, Frasca F (Oct 2009). "Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease.". Endocr Rev 30 (6): 586–623. doi:10.1210/er.2008-0047. PMID 19752219.
^ Knudsen L, De Meyts P, Kiselyov VV. (Feb 2012). "Insight into the molecular basis for the kinetic differences between the two insulin receptor isoforms.". Biochemical J. 440 (3): 397–403. doi:10.1042/BJ20110550. PMID 21838706.
^ ^a ^b ^c Smith BJ, Huang K (April 2010). "Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists.". PNAS 107 (15): 6771–6. Bibcode 2010PNAS..107.6771S. doi:10.1073/pnas.1001813107. PMC 2872410. PMID 20348418. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2872410/.
^ ^a ^b McKern NM, Lawrence MC, Ward CW et al. (Sep 2006). "Structure of the insulin receptor ectodomain reveals a folded-over conformation.". Nature 7108 (443): 218–21. Bibcode 2006Natur.443..218M. doi:10.1038/nature05106. PMID 16957736.
^ ^a ^b ^c Kiselyov VV, Versteyhe S, Gauguin L, De Meyts P (Feb 2009). "Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation.". Mol Syst Biol. 253 (5). doi:10.1038/msb.2008.78. PMC 2657531. PMID 19225456. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2657531/.
^ ^a ^b de Meyts P, Roth J, Neville DM Jr, Gavin JR 3rd, Lesniak MA (Nov 1973). "Insulin interactions with its receptors: experimental evidence for negative cooperativity.". Biochem Biophys Res Commun. 55 (1): 154–61. doi:10.1016/S0006-291X(73)80072-5. PMID 4361269.
^ Longo N, Wang Y, Smith SA, Langley SD, DiMeglio LA, Giannella-Neto D (2002). "Genotype-phenotype correlation in inherited severe insulin resistance". Hum. Mol. Genet. 11 (12): 1465–75. doi:10.1093/hmg/11.12.1465. PMID 12023989.
^ Duckworth WC, Bennett RG, Hamel FG (1998). "Insulin degradation: progress and potential". Endocr. Rev. 19 (5): 608–24. doi:10.1210/er.19.5.608. PMID 9793760.
^ Maddux, B A; Goldfine I D (Jan. 2000). "Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit". Diabetes (UNITED STATES) 49 (1): 13–9. doi:10.2337/diabetes.49.1.13. ISSN 0012-1797. PMID 10615944.
^ Maegawa, H; Ugi S, Adachi M, Hinoda Y, Kikkawa R, Yachi A, Shigeta Y, Kashiwagi A (Mar. 1994). "Insulin receptor kinase phosphorylates protein tyrosine phosphatase containing Src homology 2 regions and modulates its PTPase activity in vitro". Biochem. Biophys. Res. Commun. (UNITED STATES) 199 (2): 780–5. doi:10.1006/bbrc.1994.1297. ISSN 0006-291X. PMID 8135823.
^ Kharitonenkov, A; Schnekenburger J, Chen Z, Knyazev P, Ali S, Zwick E, White M, Ullrich A (Dec. 1995). "Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction". J. Biol. Chem. (UNITED STATES) 270 (49): 29189–93. doi:10.1074/jbc.270.49.29189. ISSN 0021-9258. PMID 7493946.
^ Langlais, P; Dong L Q, Hu D, Liu F (Jun. 2000). "Identification of Grb10 as a direct substrate for members of the Src tyrosine kinase family". Oncogene (ENGLAND) 19 (25): 2895–903. doi:10.1038/sj.onc.1203616. ISSN 0950-9232. PMID 10871840.
^ Hansen, H; Svensson U, Zhu J, Laviola L, Giorgino F, Wolf G, Smith R J, Riedel H (Apr. 1996). "Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus". J. Biol. Chem. (UNITED STATES) 271 (15): 8882–6. doi:10.1074/jbc.271.15.8882. ISSN 0021-9258. PMID 8621530.
^ Liu, F; Roth R A (Oct. 1995). "Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 92 (22): 10287–91. Bibcode 1995PNAS...9210287L. doi:10.1073/pnas.92.22.10287. ISSN 0027-8424. PMC 40781. PMID 7479769. //www.ncbi.nlm.nih.gov/pmc/articles/PMC40781/.
^ He, W; Rose D W, Olefsky J M, Gustafson T A (Mar. 1998). "Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains". J. Biol. Chem. (UNITED STATES) 273 (12): 6860–7. doi:10.1074/jbc.273.12.6860. ISSN 0021-9258. PMID 9506989.
^ Frantz, J D; Giorgetti-Peraldi S, Ottinger E A, Shoelson S E (Jan. 1997). "Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains". J. Biol. Chem. (UNITED STATES) 272 (5): 2659–67. doi:10.1074/jbc.272.5.2659. ISSN 0021-9258. PMID 9006901.
^ Kasus-Jacobi, A; Béréziat V, Perdereau D, Girard J, Burnol A F (Apr. 2000). "Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2". Oncogene (ENGLAND) 19 (16): 2052–9. doi:10.1038/sj.onc.1203469. ISSN 0950-9232. PMID 10803466.
^ Braiman, L; Alt A, Kuroki T, Ohba M, Bak A, Tennenbaum T, Sampson S R (Apr. 2001). "Insulin induces specific interaction between insulin receptor and protein kinase C delta in primary cultured skeletal muscle". Mol. Endocrinol. (United States) 15 (4): 565–74. doi:10.1210/me.15.4.565. ISSN 0888-8809. PMID 11266508.
^ Rosenzweig, Tovit; Braiman Liora, Bak Asia, Alt Addy, Kuroki Toshio, Sampson Sanford R (Jun. 2002). "Differential effects of tumor necrosis factor-alpha on protein kinase C isoforms alpha and delta mediate inhibition of insulin receptor signaling". Diabetes (United States) 51 (6): 1921–30. doi:10.2337/diabetes.51.6.1921. ISSN 0012-1797. PMID 12031982.
^ Aguirre, Vincent; Werner Eric D, Giraud Jodel, Lee Yong Hee, Shoelson Steve E, White Morris F (Jan. 2002). "Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action". J. Biol. Chem. (United States) 277 (2): 1531–7. doi:10.1074/jbc.M101521200. ISSN 0021-9258. PMID 11606564.
^ Sawka-Verhelle, D; Tartare-Deckert S, White M F, Van Obberghen E (Mar. 1996). "Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591–786". J. Biol. Chem. (UNITED STATES) 271 (11): 5980–3. doi:10.1074/jbc.271.11.5980. ISSN 0021-9258. PMID 8626379.
^ Kotani, K; Wilden P, Pillay T S (Oct. 1998). "SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase". Biochem. J. (ENGLAND) 335 (1): 103–9. ISSN 0264-6021. PMC 1219757. PMID 9742218. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1219757/.
^ Nelms, K; O'Neill T J, Li S, Hubbard S R, Gustafson T A, Paul W E (Dec. 1999). "Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain". Mamm. Genome (UNITED STATES) 10 (12): 1160–7. doi:10.1007/s003359901183. ISSN 0938-8990. PMID 10594240.
^ O'Neill, T J; Zhu Y, Gustafson T A (Apr. 1997). "Interaction of MAD2 with the carboxyl terminus of the insulin receptor but not with the IGFIR. Evidence for release from the insulin receptor after activation". J. Biol. Chem. (UNITED STATES) 272 (15): 10035–40. doi:10.1074/jbc.272.15.10035. ISSN 0021-9258. PMID 9092546.

External links

Insulin receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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1. インスリン受容体の構造および機能 structure and function of the insulin receptor
2. インスリン作用 insulin action
3. インスリン抵抗性：定義および臨床像 insulin resistance definition and clinical spectrum
4. 黒色表皮腫 acanthosis nigricans
5. 糖尿病および遺伝的糖尿病症候群の分類 classification of diabetes mellitus and genetic diabetic syndromes

English Journal

Overexpression of PGC-1α Increases Fatty Acid Oxidative Capacity of Human Skeletal Muscle Cells.

Nikoli? N, Rhedin M, Rustan AC, Storlien L, Thoresen GH, Stromstedt M.SourceDepartment of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, N-0316 Oslo, Norway.
Biochemistry research international.Biochem Res Int.2012;2012:714074. Epub 2011 Sep 4.
We investigated the effects of PGC-1α (peroxisome proliferator-activated receptor γ coactivator-1α) overexpression on the oxidative capacity of human skeletal muscle cells ex vivo. PGC-1α overexpression increased the oxidation rate of palmitic acid and mRNA expression of genes regulating lipid m
PMID 21904680

Japanese Journal

Comparison of effects of bezafibrate and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 and adipocytokine levels in dyslipidemic subjects with impaired glucose tolerance or type 2 diabetes mellitus: Results from a crossover study

Noguchi Tohru,Kobayashi Junji,Yagi Kunimasa,Nohara Atsushi,Yamaaki Naoto,Sugihara Masako,Ito Naoko,Oka Rie,Kawashiri Masaaki,Tada Hayato,Takata Mutsuko,Inazu Akihiro,Yamagishi Masakazu,Mabuchi Hiroshi
Atherosclerosis 217 (1), pp. 165-170 217(1), 165-170, 2011-07
… Background: Bezafibrate and fenofibrate show different binding properties against peroxisome proliferator-activated receptor subtypes, which could cause different clinical effects on circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) levels and on various metabolic markers. … 0.01), whereas bezafibrate significantly improved glucose tolerance (insulin, -17.0%, p < …
NAID 120003141452

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★リンクテーブル★

リンク元	「インシュリン受容体」「インスリンレセプター」
拡張検索	「insulin receptor substrate」「insulin receptor substrates」

「インシュリン受容体」

Insulin receptor
	; Insulin Receptor Ectodomain (PDB:3LOH)
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1GAG, 1I44, 1IR3, 1IRK, 1P14, 1RQQ, 2AUH, 2B4S, 2DTG, 2HR7, 2Z8C, 3BU3, 3BU5, 3BU6, 3EKK, 3EKN, 3ETA, 3LOH, 3W11, 3W12, 3W13, 3W14
Identifiers
Symbols	INSR; CD220; HHF5
External IDs	OMIM: 147670 MGI: 96575 HomoloGene: 20090 ChEMBL: 1981 GeneCards: INSR Gene
EC number	2.7.10.1
Gene Ontology
Molecular function	• protein tyrosine kinase activity; • receptor signaling protein tyrosine kinase activity; • insulin-activated receptor activity; • insulin-like growth factor receptor binding; • protein binding; • ATP binding; • GTP binding; • protein phosphatase binding; • lipoic acid binding; • insulin-like growth factor I binding; • insulin-like growth factor II binding; • protein complex binding; • SH2 domain binding; • 3-phosphoinositide-dependent protein kinase binding; • phosphatidylinositol 3-kinase binding; • insulin binding; • insulin receptor substrate binding; • PTB domain binding;
Cellular component	• nucleus; • cytosol; • plasma membrane; • integral to plasma membrane; • insulin receptor complex; • caveola; • endosome membrane; • membrane; • synapse;
Biological process	• activation of MAPK activity; • negative regulation of protein phosphorylation; • positive regulation of protein phosphorylation; • heart morphogenesis; • carbohydrate metabolic process; • regulation of transcription, DNA-dependent; • G-protein coupled receptor signaling pathway; • positive regulation of cell proliferation; • insulin receptor signaling pathway; • response to glucose stimulus; • response to manganese ion; • regulation of hydrogen peroxide metabolic process; • positive regulation of glycoprotein biosynthetic process; • negative regulation of gene expression; • response to activity; • peptidyl-tyrosine phosphorylation; • transformation of host cell by virus; • signal transduction by phosphorylation; • male sex determination; • positive regulation of cell migration; • exocrine pancreas development; • activation of protein kinase activity; • activation of protein kinase B activity; • response to estradiol stimulus; • negative regulation of transporter activity; • cellular response to insulin stimulus; • response to vitamin D; • response to testosterone stimulus; • response to tumor necrosis factor; • glucose homeostasis; • positive regulation of MAPK cascade; • positive regulation of nitric oxide biosynthetic process; • fat cell differentiation; • response to ethanol; • positive regulation of glycogen biosynthetic process; • positive regulation of DNA replication; • positive regulation of glycolysis; • positive regulation of mitosis; • regulation of embryonic development; • positive regulation of glucose import; • protein autophosphorylation; • positive regulation of developmental growth; • protein heterotetramerization; • response to glucocorticoid stimulus; • positive regulation of protein kinase B signaling cascade; • positive regulation of respiratory burst; • cellular response to growth factor stimulus;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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　　[★]

英: insulin receptor
関: インスリン受容体、インスリンレセプター

「インスリンレセプター」

　　[★]

英: insulin receptor
関: インシュリン受容体、インスリン受容体

「insulin receptor substrate」

　　[★]

インスリン受容体基質、インスリンレセプター基質、インシュリン受容体基質、インシュリンレセプター基質

関: IRS
同: IRS
同: IRS

「insulin receptor substrates」

　　[★] インスリン受容体基質 IRSs

[pmid19274663-1] Ward CW, Lawrence MC (April 2009). "Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor". BioEssays 31 (4): 422–34. doi:10.1002/bies.200800210. PMID 19274663.

[pmid2859121-2] Ebina Y, Ellis L (April 1985). "The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling.". Cell 40 (4): 747–58. doi:10.1016/0092-8674(85)90334-4. PMID 2859121.

[pmid22355074-3] Malaguarnera R, Belfiore A (February 2012). "Proinsulin Binds with High Affinity the Insulin Receptor Isoform A and Predominantly Activates the Mitogenic Pathway.". Endocrinology. Epub. doi:10.1210/en.2011-1843. PMID 22355074.

[pmid19752219-4] Belfiore A, Frasca F (Oct 2009). "Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease.". Endocr Rev 30 (6): 586–623. doi:10.1210/er.2008-0047. PMID 19752219.

[pmid21838706-5] Knudsen L, De Meyts P, Kiselyov VV. (Feb 2012). "Insight into the molecular basis for the kinetic differences between the two insulin receptor isoforms.". Biochemical J. 440 (3): 397–403. doi:10.1042/BJ20110550. PMID 21838706.

[pmid20348418-6] Smith BJ, Huang K (April 2010). "Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists.". PNAS 107 (15): 6771–6. Bibcode 2010PNAS..107.6771S. doi:10.1073/pnas.1001813107. PMC 2872410. PMID 20348418. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2872410/.

[pmid16957736-7] McKern NM, Lawrence MC, Ward CW et al. (Sep 2006). "Structure of the insulin receptor ectodomain reveals a folded-over conformation.". Nature 7108 (443): 218–21. Bibcode 2006Natur.443..218M. doi:10.1038/nature05106. PMID 16957736.

[pmid19225456-8] Kiselyov VV, Versteyhe S, Gauguin L, De Meyts P (Feb 2009). "Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation.". Mol Syst Biol. 253 (5). doi:10.1038/msb.2008.78. PMC 2657531. PMID 19225456. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2657531/.

[pmid4361269-9] Meyts P, Roth J, Neville DM Jr, Gavin JR 3rd, Lesniak MA (Nov 1973). "Insulin interactions with its receptors: experimental evidence for negative cooperativity.". Biochem Biophys Res Commun. 55 (1): 154–61. doi:10.1016/S0006-291X(73)80072-5. PMID 4361269.

[pmid12023989-10] Longo N, Wang Y, Smith SA, Langley SD, DiMeglio LA, Giannella-Neto D (2002). "Genotype-phenotype correlation in inherited severe insulin resistance". Hum. Mol. Genet. 11 (12): 1465–75. doi:10.1093/hmg/11.12.1465. PMID 12023989.

[pmid9793760-11] Duckworth WC, Bennett RG, Hamel FG (1998). "Insulin degradation: progress and potential". Endocr. Rev. 19 (5): 608–24. doi:10.1210/er.19.5.608. PMID 9793760.

[pmid10615944-12] Maddux, B A; Goldfine I D (Jan. 2000). "Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit". Diabetes (UNITED STATES) 49 (1): 13–9. doi:10.2337/diabetes.49.1.13. ISSN 0012-1797. PMID 10615944.

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insulin receptor