イノシトール-1
- 関
- glycerophosphoinositol inositolphosphodiesterase
WordNet
- of a compound having atoms arranged in a ring structure
- recurring in cycles (同)cyclical
- conforming to the Carnot cycle
- forming a whorl or having parts arranged in a whorl; "cyclic petals"; "cyclic flowers"
- marked by repeated cycles
- a salt of phosphoric acid (同)orthophosphate, inorganic_phosphate
- carbonated drink with fruit syrup and a little phosphoric acid
- an optically inactive alcohol that is a component of the vitamin B complex
PrepTutorEJDIC
- 〈U〉リン酸塩 / 《複数形で》リン酸肥料
UpToDate Contents
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English Journal
- Can enzymatic activity, or otherwise, be inferred from structural studies of annexin III?
- Perron B1, Lewit-Bentley A, Geny B, Russo-Marie F.Author information 1Institut Cochin de Génétique Moléculaire, U332 INSERM, 22 rue Méchain, 75014 Paris, France.AbstractAnnexin III, a putative inositol (1,2)-phosphohydrolase, was co-crystallized with inositol 2-phosphate, the inhibitor of the reaction, and its structure was solved to 1.95 A resolution. No enzyme active site was observed in the structure. Assays for enzymatic activity were also negative. Search for annexin III-inositol phosphate interactions using the BIAcoreTM system revealed an affinity for inositol cyclic (1,2)-phosphate, suggesting annexin III may sequester the molecule in the cell. The BIAcoreTM system used with different phospholipids showed that annexin III displays specificity for phosphatidylethanolamine, but not for phosphatidylinositols. Interestingly, a molecule of ethanolamine was found bound to the protein in the crystal structure. Coupled with the fact that this is a particularly abundant phospholipid in granules specific to neutrophils, cells where annexin III is highly expressed, our finding could be pointing to a physiological role of annexin III.
- The Journal of biological chemistry.J Biol Chem.1997 Apr 25;272(17):11321-6.
- Annexin III, a putative inositol (1,2)-phosphohydrolase, was co-crystallized with inositol 2-phosphate, the inhibitor of the reaction, and its structure was solved to 1.95 A resolution. No enzyme active site was observed in the structure. Assays for enzymatic activity were also negative. Search for
- PMID 9111038
- Identification of a phosphodiesterase that converts inositol cyclic 1:2-phosphate to inositol 2-phosphate.
- Ross TS1, Majerus PW.Author information 1Division of Hematology/Oncology, Washington University, St. Louis, Missouri 63110-1093.AbstractInositol 2-phosphate (Ins(2)P) has been identified in several cell types. The cellular levels of Ins(2)P appear to be directly correlated with the levels of inositol 1:2-cyclic phosphate (cIns(1:2)P) (Ross, T. S., Wang, F. P., and Majerus, P. W. (1992) J. Biol. Chem. 267, 19919-19923). In this study we have detected an enzyme in extracts from CV-1 cells and rat cerebellum that converts cIns(1:2)P to Ins(2)P and inositol 1-phosphate. This enzyme (designated cyclic hydrolase II) is not the same protein previously designated cIns(1:2)P 2-phosphohydrolase (cyclic hydrolase I). The products, heat inactivation curves, pH optima, and metal dependence of these two activities are different, and the two activities were separated by DEAE and gel filtration chromatography. Mixing of cyclic hydrolase I with cyclic hydrolase II does not effect the activity of either. The Km of the CV-1 cyclic hydrolase II for D-cIns(1:2)P is 10 microM. The enzyme is approximately 55 kDa as estimated by gel filtration analysis in the presence of sodium chloride and 120 kDa in its absence.
- The Journal of biological chemistry.J Biol Chem.1992 Oct 5;267(28):19924-8.
- Inositol 2-phosphate (Ins(2)P) has been identified in several cell types. The cellular levels of Ins(2)P appear to be directly correlated with the levels of inositol 1:2-cyclic phosphate (cIns(1:2)P) (Ross, T. S., Wang, F. P., and Majerus, P. W. (1992) J. Biol. Chem. 267, 19919-19923). In this study
- PMID 1328187
- Chromosomal localization of the human annexin III (ANX3) gene.
- Tait JF1, Frankenberry DA, Miao CH, Killary AM, Adler DA, Disteche CM.Author information 1Department of Laboratory Medicine, University of Washington, Seattle 98195.AbstractThe annexins or lipocortins are a new family of calcium-dependent phospholipid-binding proteins. Annexin III has been previously identified as inositol 1,2-cyclic phosphate 2-phosphohydrolase (EC 3.1.4.36), an enzyme of inositol phosphate metabolism, and also as placental anticoagulant protein III, lipocortin III, calcimedin 35-alpha, and an abundant neutrophil cytoplasmic protein. In this study, the gene (ANX3) encoding annexin III was localized to human chromosome 4 at band q21 (q13-q22) by (1) polymerase chain reaction analysis of a human-rodent hybrid cell panel, confirmed by genomic Southern blot analysis of the same panel with a cDNA probe and (2) in situ hybridization with a cDNA probe.
- Genomics.Genomics.1991 Jun;10(2):441-8.
- The annexins or lipocortins are a new family of calcium-dependent phospholipid-binding proteins. Annexin III has been previously identified as inositol 1,2-cyclic phosphate 2-phosphohydrolase (EC 3.1.4.36), an enzyme of inositol phosphate metabolism, and also as placental anticoagulant protein III,
- PMID 1830024
Related Links
- Inositol 1,2-cyclic phosphate 2-phosphohydrolase explanation. Information about Inositol 1,2-cyclic phosphate 2-phosphohydrolase in Free online English dictionary. What is Inositol 1,2-cyclic phosphate 2-phosphohydrolase ...
- A membrane-bound activity catalysing phosphatidylinositol breakdown to 1,2-diacylglycerol, D-myoinositol 1:2-cyclic phosphate an D-myoinositol 1-phosphate. Properties and subcellular distribution in rat cerebral cortex. Biochem J ...
★リンクテーブル★
[★]
- 英
- inositol 1
- 関
- グリセロホスホイノシトールイノシトールホスホジエステラーゼ
[★]
グリセロホスホイノシトールイノシトールホスホジエステラーゼ
- 関
- inositol 1,2-cyclic phosphate 2-phosphohydrolase
[★]
- 関
- inorganic phosphate、orthophosphate、orthophosphoric acid、phospho、phosphoester、phosphoric、phosphoric acid、phosphoric acid ester、phosphorus
[★]
- 関
- annular、circular、cyclical、cyclicity、cyclo、periodic、periodicity
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ホスホヒドロラーゼ、リン酸加水分解酵素
- 関
- phosphatase、phosphoric monoester hydrolase
[★]
イノシトール
- 関
- myoinositol