WordNet
- the atomic process that occurs during a chemical reaction; "he determined unique mechanisms for the photochemical reactions" (同)chemical mechanism
- the technical aspects of doing something; "a mechanism of social control"; "mechanisms of communication"; "the mechanics of prose style" (同)mechanics
- device consisting of a piece of machinery; has moving parts that perform some function
- (philosophy) the philosophical theory that all phenomena can be explained in terms of physical or biological causes
- a natural object resembling a machine in structure or function; "the mechanism of the ear"; "the mechanism of infection"
- a substance that retards or stops an activity
- restrictive of action; "a repressive regime"; "an overly strict and inhibiting discipline" (同)repressive, repressing
PrepTutorEJDIC
- 〈C〉機械;(部分的な)機械装置 / 〈C〉(機械装置に似た)機構 / 〈C〉(物事が行われる)仕組み,方法 / 〈U〉機械論
- 抑制する人(物) / 化学反応抑制剤
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- 1. Chapter 6A：ホルモンの作用機序 chapter 6a mechanisms of hormone action
- 2. 抗真菌剤感受性試験 antifungal susceptibility testing
- 3. 肥満の病因 pathogenesis of obesity
- 4. 虚血プレコンディショニングの定義および病因 definition and pathogenesis of ischemic preconditioning
- 5. 成人における市中肺炎の治療に関する抗菌薬の研究 antibiotic studies for the treatment of community acquired pneumonia in adults
English Journal
- Structural characterization of the regulatory domain of brain carnitine palmitoyltransferase 1.
- Samanta S, Situ AJ, Ulmer TS.Author information Department of Biochemistry & Molecular Biology and Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033.AbstractNeurons contain a mammalian-specific isoform of the enzyme carnitine palmitoyltransferase 1 (CPT1C) that couples malonyl-CoA to ceramide levels thereby contributing to systemic energy homeostasis and feeding behavior. In contrast to CPT1A, which controls the rate-limiting step of long-chain fatty acid β-oxidation in all tissues, the biochemical context and regulatory mechanism of CPT1C are unknown. CPT1 enzymes are comprised of an N-terminal regulatory domain and a C-terminal catalytic domain (CD) that are separated by two transmembrane helices. In CPT1A, the regulatory domain, termed N, adopts an inhibitory and non-inhibitory state, Nα and Nβ, respectively, which differ in their association with the CD. To provide insight into the regulatory mechanism of CPT1C, we have determined the structure of its regulatory domain (residues Met1-Phe50) by NMR spectroscopy. In relation to CPT1A, the inhibitory Nα state was found to be structurally homologues whereas the non-inhibitory Nβ state was severely destabilized, suggesting a change in overall regulation. The destabilization of Nβ may contribute to the low catalytic activity of CPT1C relative to CPT1A and makes its association with the CD unlikely. In analogy to the stabilization of Nβ by the CPT1A CD, non-inhibitory interactions of N of CPT1C with another protein may exist. © 2013 Wiley Periodicals, Inc. Biopolymers 101: 398-405, 2014.
- Biopolymers.Biopolymers.2014 Apr;101(4):398-405. doi: 10.1002/bip.22396.
- Neurons contain a mammalian-specific isoform of the enzyme carnitine palmitoyltransferase 1 (CPT1C) that couples malonyl-CoA to ceramide levels thereby contributing to systemic energy homeostasis and feeding behavior. In contrast to CPT1A, which controls the rate-limiting step of long-chain fatty ac
- PMID 24037959
- Diminution of 2,3,5-triphenyltetrazolium chloride toxicity on Listeria monocytogenes growth by iron source addition to the culture medium.
- Junillon T, Flandrois JP.Author information Université de Lyon 1, F-69000 Lyon, CNRS, UMR5558, Laboratoire de Biométrie et Biologie Evolutive, F-69622 Villeurbanne, France; bioMerieux SA département Microbiologie industrielle, Chemin de l'Orme 69280 Marcy l'Etoile, France. Electronic address: junillon.thomas@hotmail.fr.AbstractTetrazolium salts (TTZ) such as 2,3,5-triphenyltetrazolium chloride (TTC) are readily reduced by bacterial populations of various genus. The reduced form of these redox indicators is conspicuously colored allowing a quick and easy detection of growth. The studies are mainly confined to Gram negative bacteria because of an important toxic effect of tetrazolium salts on Gram positive bacteria. Indeed, we observed an important impact of different tetrazolium salts on Listeria monocytogenes growth, curiously limited to an increase in the duration of the lag phase. In this study, we demonstrate that increasing the iron concentration in a medium containing TTC leads to a significant decrease of the lag phase. L. monocytogenes growth was kinetically measured and growth parameters were estimated using the Baranyi model. While lag phase diminution was found to be iron concentration dependent, growth rate was not affected. Addition of iron enables growth of some strains totally inhibited by a 0.4 g/l of TTC and for the other a significant reduction of the latency is observed. The nature of the mechanism resulting in a decrease of the observed lag phase remains unclear. Then, the use of iron supplementation may be proposed to overcome the inhibitory effect of TTC on L. monocytogenes.
- Food microbiology.Food Microbiol.2014 Apr;38:1-5. doi: 10.1016/j.fm.2013.07.005. Epub 2013 Jul 31.
- Tetrazolium salts (TTZ) such as 2,3,5-triphenyltetrazolium chloride (TTC) are readily reduced by bacterial populations of various genus. The reduced form of these redox indicators is conspicuously colored allowing a quick and easy detection of growth. The studies are mainly confined to Gram negative
- PMID 24290619
- Requirement of miR-144 in CsA Induced Proliferation and Invasion of Human Trophoblast Cells by Targeting Titin.
- Liang Y, Lin Q, Luo F, Wu W, Yang T, Wan S.Author information National Engineering Laboratory for Rice and By-Product Deep Processing, Central South University of Forestry and Technology, Hunan Province, 410004, People's Republic of China.AbstractMicroRNAs (miRNAs) are endogenous 19-25 nucleotide noncoding single-stranded RNAs that regulate gene expression by blocking the translation or decreasing the stability of mRNAs. In this study, with the treatment of CsA (Cyclosporin A), we showed that miR144 expression levels were decreased while titin mRNA expression levels were increased in human trophoblast (HT) cells, and identified titin as a novel direct target of miR-144. Overexpression of miR-144 suppressed titin and its downstream signaling molecule such as p-ERK1/2 and MMP2/9 expression, and attenuated cell proliferation and invasion. Forced expression of titin can partly rescue the inhibitory effect of miR-144 in the cells. Taken together, these findings will shed light to the role and mechanism of miR-144 in regulating HT cells proliferation and invasion via miR-144/titin axis, and miR-144 may serve as a potential therapeutic target in HT in the future. J. Cell. Biochem. 115: 690-696, 2014. © 2013 Wiley Periodicals, Inc.
- Journal of cellular biochemistry.J Cell Biochem.2014 Apr;115(4):690-6. doi: 10.1002/jcb.24710.
- MicroRNAs (miRNAs) are endogenous 19-25 nucleotide noncoding single-stranded RNAs that regulate gene expression by blocking the translation or decreasing the stability of mRNAs. In this study, with the treatment of CsA (Cyclosporin A), we showed that miR144 expression levels were decreased while tit
- PMID 24453045
Japanese Journal
- Orexin neurons receive glycinergic innervations
- Hondo Mari,Furutani Naoki,Yamasaki Miwako,Watanabe Masahiko,Sakurai Takeshi
- PLoS ONE 6(9), e25076, 2011-09-16
- … Glycine, a nonessential amino-acid that acts as an inhibitory neurotransmitter in the central nervous system, is currently used as a dietary supplement to improve the quality of sleep, but its mechanism of action is poorly understood. … Double-labeling immunoelectron microscopy demonstrated that glycine receptor alpha subunits were localized in the postsynaptic membrane of symmetrical inhibitory synapses on orexin neurons. …
- NAID 120003497597
- Central circuitries for body temperature regulation and fever.
- Nakamura Kazuhiro
- American journal of physiology. Regulatory, integrative and comparative physiology 301(5), R1207-R1228, 2011-09
- … These afferent signals are integrated and affect the activity of GABAergic inhibitory projection neurons descending from the POA to the dorsomedial hypothalamus (DMH) or to the rostral medullary raphe region (rMR). … This central thermoregulatory mechanism also functions for metabolic regulation and stress-induced hyperthermia. …
- NAID 120003573882
Related Links
- 8 Jan 2004 ... Inhibitory mechanism of store-operated Ca2+ channels by zinc. Gore A, Moran A, Hershfinkel M, Sekler I. Physiology and Morphology, Faculty of Health Science and the Zlotowski Center for Neuroscience, Ben Gurion ...
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★リンクテーブル★
| リンク元 | 「抑制機構」「阻害機構」「抑制メカニズム」 |
| 関連記事 | 「inhibitor」「inhibitory」「mechanism」 |
「抑制機構」
「阻害機構」
「抑制メカニズム」
「inhibitor」
- n.
「inhibitory」
- 抑制性の、抑制的な、阻害性の
「mechanism」
- n.