hyperphosphatemia

高リン血症

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/15 15:24:10」(JST)

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Hyperphosphatemia
Classification and external resources
Phosphate group chemical structure
ICD-9	275.3
DiseasesDB	20722
eMedicine	med/1097
MeSH	D054559

Hyperphosphatemia is an electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood. Often, calcium levels are lowered (hypocalcemia) due to precipitation of phosphate with the calcium in tissues. Average phosphorus levels should be between 0.81 mmol/L and 1.45 mmol/L.

Signs and symptoms

Signs and symptoms include ectopic calcification, secondary hyperparathyroidism, and renal osteodystrophy.

Causes

Hypoparathyroidism: In this situation, there are low levels of Parathyroid hormone (PTH). PTH normally inhibits renal reabsorption of phosphate, and so without enough PTH there is more reabsorption of the phosphate.

Chronic renal failure: When the kidneys aren't working well, there will be increased phosphate retention.

Osteomalacia, which may be caused by the insufficient content of vitamin D in the diet, the lack of sunlight, malabsorption or renal disorders.

Drugs: hyperphosphatemia can also be caused by taking oral sodium phosphate solutions prescribed for bowel preparation for colonoscopy in children.

Treatment

High phosphate levels can be avoided with phosphate binders and dietary restriction of phosphate.

See also

• Hypophosphatemia
• Hypophosphatasia

References

UpToDate Contents

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• 1. Overview of the causes and treatment of hyperphosphatemia
• 2. 慢性腎疾患における高リン血症の治療 treatment of hyperphosphatemia in chronic kidney disease
• 3. 急性腎障害（急性腎不全）のマネージメントの概要 overview of the management of acute kidney injury acute renal failure
• 4. 慢性腎臓病に伴う骨・ミネラル代謝異常（CKD-MBD）の概要 overview of chronic kidney disease mineral bone disease ckd mbd
• 5. 腫瘍崩壊症候群：定義、発病メカニズム、臨床症状、原因および危険因子 tumor lysis syndrome definition pathogenesis clinical manifestations etiology and risk factors

English Journal

• Sevelamer is an Effective Drug in Treating Hyperphosphatemia Due to Tumor Lysis Syndrome in Children: A Developing World Experience.

• Kahlon DK1, Dinand V1, Yadav SP2, Sachdeva A1.
• Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion.Indian J Hematol Blood Transfus.2016 Mar;32(1):78-82. doi: 10.1007/s12288-014-0481-2. Epub 2014 Dec 3.
• We report here a study on efficacy of sevelamer hydrochloride in treating hyperphosphatemia due to tumor lysis syndrome (TLS) in a developing world setting. Twenty one children with hyperphosphatemia due to TLS were included. All received hyper-hydration, allopurinol and sevelamer. Efficacy was asse
• PMID 26855510

• Pharmacodynamic Actions of a Long-Acting PTH Analog (LA-PTH) in Thyroparathyroidectomized (TPTX) Rats and Normal Monkeys.

• Shimizu M1, Joyashiki E1, Noda H1, Watanabe T1,2, Okazaki M1, Nagayasu M1, Adachi K1, Tamura T1, Potts JT Jr2, Gardella TJ2, Kawabe Y1.
• Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.J Bone Miner Res.2016 Feb 10. doi: 10.1002/jbmr.2811. [Epub ahead of print]
• Hypoparathyroidism is a disease of chronic hypocalcemia and hyperphosphatemia due to a deficiency of parathyroid hormone (PTH). PTH and analogs of the hormone are of interest as potential therapies. Accordingly, we examined the pharmacological properties of a long-acting PTH analog, [Ala1,3,12,18,22
• PMID 26865415

• Clinical characteristics and prevalence of complications of chronic kidney disease in children: the Taiwan Pediatric Renal Collaborative study.

• Chou HH1,2, Lin CY3, Chiou YH4, Tain YL5, Wang YF6, Wang HH7,8, Chiou YY9,10.
• Pediatric nephrology (Berlin, Germany).Pediatr Nephrol.2016 Feb 5. [Epub ahead of print]
• BACKGROUND: Little information is available regarding the clinical characteristics and prevalence of complications in children with chronic kidney disease (CKD), especially in early disease stages. The objective of this study was to determine the clinical characteristics and prevalence of complicati
• PMID 26850057

Japanese Journal

• 長時間透析により巨大異所性石灰化が改善し生体腎移植が可能となった1例

• 石川 康暢,西尾 妙織,千葉 尚市,佐藤 亜樹子,耒海 美穂,池之上 辰義,中垣 祐,中沢 大悟,伊藤 政典,柴崎 跡也,森田 研,野々村 克也,小池 隆夫
• 日本透析医学会雑誌 = Journal of Japanese Society for Dialysis Therapy 44(2), 173-179, 2011-02-28
• 症例は35歳，男性．1998年にGoodpasture症候群にて血液透析を導入されたが，ブラッドアクセストラブルのため2000年より腹膜透析に変更された．2003年12月より高P血症が原因でCa・P積が90(mg/dL)2を超え，右肩に手拳大，左臀部に小児頭大の異所性石灰化を認めるようになった．2004年10月より血液透析へ移行されたが異所性石灰化は改善しなかった．2005年2月24日に母をドナー …
• NAID 10029406098

• 無機リン酸代謝調節における分子栄養学研究 : (平成22年度日本栄養・食糧学会学会賞受賞)

• 宮本 賢一
• 日本栄養・食糧学会誌 64(3), 137-149, 2011
• リンは生体に広く分布しており, 細胞内シグナル伝達, エネルギー代謝, 核酸合成および酸-塩基などに関与している。リン代謝調節機構は, その破綻が低リン血症や高リン血症から生じる病態によって明白なように生命維持に必須である。低リン血症はクル病および骨軟化症を引き起こす。一方で, 高リン血症は心血管疾患に深く関与している。血中リン濃度維持の中心臓器は腎臓であり, また腸管および骨の三つの臓器が協調し …
• NAID 130001034105

Related Links

• Hyperphosphatemia - Diseases & Conditions - Medscape ...

Hyperphosphatemia. Hyperphosphatemia, that is, an abnormally high serum phosphate level, can result from increased phosphate (PO4) intake, decreased phosphate excretion, or a disorder that shifts intracellular ...

• Hyperphosphatemia

Background Hyperphosphatemia, that is, an abnormally high serum phosphate level, can result from increased phosphate (PO 4) intake, decreased phosphate excretion, or a disorder that shifts intracellular phosphate to extracellular ...

Related Pictures

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★リンクテーブル★

リンク元

「高リン血症」

「高リン血症」

　　[★]

英

hyperphosphatemia

同

高リン酸血症、高リン酸塩血症

関

リン、低リン血症。

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高リン血症 : 約 40,100 件
高リン酸血症 : 約 41,300 件
高リン血症 hyperphosphatemia : 約 2,780 件
高リン酸血症 hyperphosphatemia : 45 件

病因

QB.D-342

参考1

• 1. リン負荷：腫瘍崩壊症候群、横紋筋融解症、乳酸アシドーシス、ケトアシドーシス、リンの過剰摂取
• 2. 腎不全
• 3. 腎尿細管におけるリン再吸収の増加：副甲状腺機能低下症、先端巨大症(GH ir IGFが直接再吸収を亢進させる)
• 4. ビスホスホネート(再吸収を亢進させることによる)
• 5. ビタミンD中毒
• 6. familial tumoral calcinosis：稀な遺伝疾患。遺伝形式はAR。(参考1に詳細な記載有り)

参考

• 1. [charged] 高リン血症の原因および治療 - uptodate [1]