ヒドロコルチゾンアセ・ネート
- 関
- hydrocortisone、hydrocortisone acetate、hydrocortisone buteprate、hydrocortisone butyrate、hydrocortisone butyrate propionate、hydrocortisone cypionate、hydrocortisone sodium phosphate、hydrocortisone sodium succinate、hydrocortisone succinate
WordNet
- an adrenal-cortex hormone (trade names Hydrocortone or Cortef) that is active in carbohydrate and protein metabolism (同)cortisol, Hydrocortone, Cortef
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/09/24 18:53:54」(JST)
[Wiki en表示]
Hydrocortisone aceponate
|
Systematic (IUPAC) name |
(11β)-21-(acetyloxy)-11-hydroxy-3,20-dioxopregn-4-en-17-yl propionate |
Clinical data |
AHFS/Drugs.com |
monograph |
Pregnancy cat. |
? |
Legal status |
? |
Routes |
Topical |
Identifiers |
CAS number |
74050-20-7 Y |
ATC code |
D07AC16 |
PubChem |
CID 68921 |
UNII |
2340UP1L2G N |
KEGG |
D06876 Y |
Chemical data |
Formula |
C26H36O7 |
Mol. mass |
460.560 g/mol |
N (what is this?) (verify)
|
See also: hydrocortisone
Hydrocortisone aceponate is a corticosteroid that is used in form of creams for the treatment of various dermatoses (skin conditions).[1] It is an ester of hydrocortisone (cortisol) with acetic acid and propionic acid.
References[edit]
- ^ Baghel, V.; Mukhopadhyay, A. (2010). "A study to evaluate the efficacy and safety of hydrocortisone aceponate 0.127% lipophilic cream in steroid responsive dermatoses in Indian patients". Indian Journal of Dermatology, Venereology, and Leprology 76 (5): 591. doi:10.4103/0378-6323.69093. PMID 20827017. edit
Corticosteroids – glucocorticoids and mineralocorticoids (H02)
(also A07EA, C05AA, D07, D10AA, R01AD, R03BA, S01BA, S02B, and S03B)
|
|
Mineralocorticoids
(3-one, 4-ene,
no FG at 16) |
- Pregnenedione: ALDOSTERONE
- 11-DEOXYCORTICOSTERONE
- HALOGENATED AT 9: Fludrocortisone
|
|
Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy) |
Pregnene
|
|
|
Pregnenedione
(+20-one)
|
- HYDROCORTISONE/CORTISOL# (Hydrocortisone aceponate
- Hydrocortisone buteprate
- Hydrocortisone butyrate)
- Budesonide
- Ciclesonide
- Deflazacort
- Medrysone
- Tixocortol
- HALOGENATED AT 6: Cloprednol
- HALOGENATED, WITH FG AT 16: Halcinonide
|
|
Pregnadiene (+1-ene)
|
- Rimexolone
- HALOGENATED, WITH FG AT 16: Flunisolide
- Triamcinolone
- Amcinonide
- Fluocinolone acetonide (Fluocinonide)
|
|
Pregnadienediol
(+21-hydroxy)
|
- Prednisone (Meprednisone)
- HALOGENATED AT 9: Fluorometholone
- HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone
- Diflucortolone
- Fluocortin)
- Desoximetasone
|
|
Pregnadienetriol
(+11-hydroxy)
|
- Prednisolone# (Methylprednisolone
- Methylprednisolone aceponate
- Prednicarbate
- Prednylidene)
- Desonide
- HALOGENATED: Fluprednisolone (Difluprednate
- Fluperolone)
- HALOGENATED, WITH FG AT 16: Dexamethasone#
- Betamethasone (Clobetasol
- Clobetasone
- Diflorasone
- Halometasone
- Ulobetasol)
- Beclometasone
- Paramethasone
- Alclometasone
- Fluclorolone acetonide
- Flumetasone
- Fluprednidene
|
|
Pregnatriene
(+2-ene)
|
|
|
Androstene
|
- HALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate
- Fluticasone furoate)
|
|
Other/ungrouped
|
- HALOGENATED: Loteprednol
- HALOGENATED, WITH FG AT 16: Fludroxycortide
- Formocortal
- Mometasone furoate
|
|
|
Aldosterone antagonists |
- Spironolactone
- Eplerenone
- Potassium canrenoate
- Canrenone
|
|
Synthesis modifiers |
- Trilostane
- Carbenoxolone
- Aminoglutethimide
- Metyrapone
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
|
|
|
noco (d)/cong/tumr, sysi/epon
|
proc, drug (A10/H1/H2/H3/H5)
|
|
|
|
Glucocorticoids
|
|
Receptor |
|
|
Enzyme
(inhibitors) |
20,22-Desmolase
|
- 22-ABC
- 3,3′-Dimethoxybenzidine
- 3-Methoxybenzidine
- Aminoglutethimide
- Cyanoketone
- Danazol
- Etomidate
- Mitotane
- Trilostane
|
|
17α-Hydroxylase,
17,20-Lyase
|
- 22-ABC
- 22-Oxime
- Abiraterone
- Bifonazole
- Clotrimazole
- Cyanoketone
- Cyproterone
- Danazol
- Econazole
- Galeterone
- Gestrinone
- Isoconazole
- Ketoconazole
- L-39
- Liarozole
- LY-207,320
- MDL-27,302
- Miconazole
- Mifepristone
- Orteronel
- Pioglitazone
- Rosiglitazone
- Spironolactone
- Stanozolol
- SU-10,603
- TGF-β
- Tioconazole
- Troglitazone
- VN/87-1
- YM116
|
|
3β-HSD
|
- 4-MA
- Azastene
- Cyanoketone
- Danazol
- Epostane
- Genistein
- Gestrinone
- Metyrapone
- Norethisterone
- Oxymetholone
- Pioglitazone
- Rosiglitazone
- Trilostane
- Troglitazone
|
|
21-Hydroxylase
|
- Aminoglutethimide
- Amphenone B
- Bifonazole
- Clotrimazole
- Diazepam
- Econazole
- Genistein
- Isoconazole
- Ketoconazole
- Metyrapone
- Miconazole
- Midazolam
- Tioconazole
|
|
11β-Hydroxylase
|
- Aminoglutethimide
- Canrenone
- Etomidate
- Fadrozole
- FETO
- Ketoconazole
- Metomidate
- Metyrapone
- Mitotane
- Potassium canrenoate
- Spironolactone
- Trilostane
|
|
18-Hydroxylase
|
- Aminoglutethimide
- Canrenone
- FAD286
- Fadrozole
- Ketoconazole
- LCI699
- Metyrapone
- Mespirenone
- Potassium canrenoate
- Spironolactone
|
|
|
Other |
Endogenous
|
- Glucocorticoids: Corticosterone
- Cortisone
- Cortodoxone/Deoxycortisol
- Hydrocortisone/Cortisol
- Antiglucocorticoids: 17-Hydroxyprogesterone
- Deoxycorticosterone
- Pregnenolone
- Progesterone
- Precursors: Cholesterol
- 22R-Hydroxycholesterol
- 20α,22R-Dihydroxycholesterol
- Pregnenolone
- 17-Hydroxypregnenolone
- 17-Hydroxyprogesterone
- Progesterone
- Deoxycorticosterone
|
|
Indirect
|
- ACTH/Corticotropin
- CRH
- DHEA
- DHEA sulfate
- Plasma proteins (Transcortin, Albumin)
- Vasopressin
|
|
Procedures
|
- Adrenalectomy
- Hypophysectomy
|
|
|
UpToDate Contents
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English Journal
- Efficacy of a 0.0584% hydrocortisone aceponate spray in presumed feline allergic dermatitis: an open label pilot study.
- Schmidt V, Buckley LM, McEwan NA, Rème CA, Nuttall TJ.SourceSchool of Veterinary Science, The University of Liverpool, Leahurst, Cheshire CH64 7TE, UK.
- Veterinary dermatology.Vet Dermatol.2012 Feb;23(1):11-6, e3-4. doi: 10.1111/j.1365-3164.2011.00993.x. Epub 2011 Jul 1.
- This study evaluated the efficacy of a 0.0584% hydrocortisone aceponate (HCA) spray (Cortavance(®); Virbac SA) in 10 cats with presumed allergic dermatitis. The cats initially received two sprays/100 cm(2) of skin once daily. Clinical lesions (a Feline Dermatitis Extent and Severity Index; FeDESI),
- PMID 21718369
- Comparable efficacy of a topical 0.0584% hydrocortisone aceponate spray and oral ciclosporin in treating canine atopic dermatitis.
- Nuttall TJ, McEwan NA, Bensignor E, Cornegliani L, Löwenstein C, Rème CA.SourceDepartment of Infection Biology, The University of Liverpool, Leahurst, Cheshire CH64 7TE, UK. timn@liv.ac.uk
- Veterinary dermatology.Vet Dermatol.2012 Feb;23(1):4-10, e1-2. doi: 10.1111/j.1365-3164.2011.00992.x. Epub 2011 Jul 1.
- This study compared the efficacy of a 0.0584% hydrocortisone aceponate (HCA) spray (Cortavance(®); Virbac SA) and ciclosporin (Atopica(®); Novartis Animal Health) in canine atopic dermatitis in a single-blind randomized controlled trial. Dogs received HCA (two sprays/100 cm(2); n=24) or ciclospori
- PMID 21718368
Japanese Journal
- 誌上学術セミナー(PART 3)犬のアレルギー性皮膚炎におけるヒドロコルチゾンアセポン酸エステルの臨床使用
- Bensignor Emmanuel
- Small animal dermatology : 小動物皮膚科専門誌 16, 64-71, 2012-07
- NAID 40019389265
- 合成副腎皮質ステロイドMethylprednisolone aceponateの抗炎症作用
- 生駒 幸弘 [他],山下 雅世,紙谷 清,中川 英彦
- 日本薬理学雑誌 98(5), 409-417, 1991
- … In the case of dermal application of the drugs to croton oil-induced ear edema in rats and picryl chlorideinduced delayed type hypersensitivity in mice, the anti-inflammatory effect of methylprednisolone aceponate (MPA) was slightly weaker than those of clobetasol 17-propionate and diflucortolone 21-valerate, but stronger than those of hydrocortisone 17-butyrate and hydrocortisone 17-butyrate 21propionate. …
- NAID 130000758814
Related Links
- Take hydrocortisone aceponate exactly as prescribed by your doctor. Follow the directions on your prescription label carefully. The Hydrocortisone Aceponate dose your doctor recommends will be based on the following (use any or all ...
- Hydrocortisone aceponate (Cortavance ®, Virbac Animal Health, Bury St. Edmunds) is a potent but very safe topical glucocorticoid. A recent publication (Nuttall and others 2009) clearly demonstrates both its safety and efficacy. In ...
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ヒドロコルチゾンブテプレート
- 関
- cortisol、hydrocortisone、hydrocortisone aceponate、hydrocortisone acetate、hydrocortisone butyrate、hydrocortisone butyrate propionate、hydrocortisone cypionate、hydrocortisone sodium phosphate、hydrocortisone sodium succinate、hydrocortisone succinate
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- cortisol、hydrocortisone、hydrocortisone aceponate、hydrocortisone acetate、hydrocortisone buteprate、hydrocortisone butyrate、hydrocortisone butyrate propionate、hydrocortisone cypionate、hydrocortisone sodium succinate、hydrocortisone succinate
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- 関
- cortisol、hydrocortisone、hydrocortisone aceponate、hydrocortisone acetate、hydrocortisone buteprate、hydrocortisone butyrate、hydrocortisone butyrate propionate、hydrocortisone cypionate、hydrocortisone sodium phosphate、hydrocortisone sodium succinate
[★]
- 関
- hydrocortisone、hydrocortisone aceponate、hydrocortisone acetate、hydrocortisone buteprate、hydrocortisone butyrate、hydrocortisone butyrate propionate、hydrocortisone sodium phosphate、hydrocortisone sodium succinate、hydrocortisone succinate
[★]
- 関
- hydrocortisone、hydrocortisone aceponate、hydrocortisone buteprate、hydrocortisone butyrate、hydrocortisone butyrate propionate、hydrocortisone cypionate、hydrocortisone sodium phosphate、hydrocortisone sodium succinate、hydrocortisone succinate
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